Contemporary prevalence of diabetic neuropathies in individuals with type 1 and type 2 diabetes in a Danish tertiary outpatient clinic
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Background
Population-based prevalence estimates of distal symmetric polyneuropathy (DPN) and diabetic autonomic neuropathy (DAN) are scares. Here we present neuropathy estimates and describe their overlap in a large cohort of people with type 1 and type 2 diabetes.
Methods
In a large population of outpatient participants, DPN was assessed using vibration perception threshold, sural nerve function, touch, pain and thermal sensation. Definite DPN was defined by the Toronto Consensus Criteria. Painful DPN was defined by Douleur Neuropathique 4 Questions. DAN measures were: cardiovascular reflex tests, electrochemical skin conductance, and gastroparesis cardinal symptom index.
Results
We included 822 individuals with type 1 (mean age (±SD) 54 ± 16 years, median [IQR] diabetes duration 26 [15–40] years) and 899 with type 2 diabetes (mean age 67 ± 11 years, median diabetes duration 16 [11−22] years).
Definite DPN was prevalent in 54 % and 68 %, and painful DPN was in 5 % and 15 % of type 1 and type 2 participants, respectively. The prevalence of DAN varied between 6 and 39 % for type 1 and 9–49 % for type 2 diabetes. DPN without other neuropathy was present in 45 % with T1D and 50 % with T2D.
Conclusion
The prevalence of DPN and DAN was high. DPN and DAN co-existed in only 50 % of cases.
Population-based prevalence estimates of distal symmetric polyneuropathy (DPN) and diabetic autonomic neuropathy (DAN) are scares. Here we present neuropathy estimates and describe their overlap in a large cohort of people with type 1 and type 2 diabetes.
Methods
In a large population of outpatient participants, DPN was assessed using vibration perception threshold, sural nerve function, touch, pain and thermal sensation. Definite DPN was defined by the Toronto Consensus Criteria. Painful DPN was defined by Douleur Neuropathique 4 Questions. DAN measures were: cardiovascular reflex tests, electrochemical skin conductance, and gastroparesis cardinal symptom index.
Results
We included 822 individuals with type 1 (mean age (±SD) 54 ± 16 years, median [IQR] diabetes duration 26 [15–40] years) and 899 with type 2 diabetes (mean age 67 ± 11 years, median diabetes duration 16 [11−22] years).
Definite DPN was prevalent in 54 % and 68 %, and painful DPN was in 5 % and 15 % of type 1 and type 2 participants, respectively. The prevalence of DAN varied between 6 and 39 % for type 1 and 9–49 % for type 2 diabetes. DPN without other neuropathy was present in 45 % with T1D and 50 % with T2D.
Conclusion
The prevalence of DPN and DAN was high. DPN and DAN co-existed in only 50 % of cases.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 108761 |
| Tidsskrift | Journal of Diabetes and its Complications |
| Vol/bind | 38 |
| Udgave nummer | 6 |
| Antal sider | 9 |
| ISSN | 1056-8727 |
| DOI | |
| Status | Udgivet - 2024 |
Bibliografisk note
Funding Information:
We thank all study participants and Ninna Hahn Tougaard, Elisabeth Buur Stougaard, Sara Hanna Naaman, Louise Rikke Barth, Louise Holmberg Storck, Anna Katrine Skau, Lisa Hoffmann Jensen, Christina Damtoft Jensen, Mark Hard\u00F8 Blitz, Laura Marr Spore, Siri R\u00F8nholdt Henriksen, Ismail Khan Omarkhail, Hans Thorvald Due, Amanda Petrea Ibsen, Nora Dakini Falck, Michelle Sand, Fie Johanne Andreasen, Lene Avnegaard, Cilia Hanna Naaman and Dalia Falah Adham Awadh from Steno Diabetes Center Copenhagen for the valued assistance with recruitment and data collection.
Publisher Copyright:
© 2024 Elsevier Inc.
ID: 391619412