Associations between exposure to early childhood adversities and middle childhood psychotic experiences in children at familial high risk of schizophrenia, bipolar disorder, and population-based controls: The Danish high risk and resilience study - VIA 7 and VIA 11
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Associations between exposure to early childhood adversities and middle childhood psychotic experiences in children at familial high risk of schizophrenia, bipolar disorder, and population-based controls : The Danish high risk and resilience study - VIA 7 and VIA 11. / Brandt, Julie Marie; Gregersen, Maja; Sondergaard, Anne; Krantz, Mette Falkenberg; Knudsen, Christina Bruun; Andreassen, Anna Krogh; Veddum, Lotte; Ohland, Jessica; Hjorthoj, Carsten; Wilms, Martin; Rohd, Sinnika Birkehoj; Greve, Aja; Burton, Birgitte Klee; Bliksted, Vibeke; Mors, Ole; Nordentoft, Merete; Thorup, Anne Amalie Elgaard; Hemager, Nicoline.
I: Psychological Medicine, Bind 53, Nr. 14, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Associations between exposure to early childhood adversities and middle childhood psychotic experiences in children at familial high risk of schizophrenia, bipolar disorder, and population-based controls
T2 - The Danish high risk and resilience study - VIA 7 and VIA 11
AU - Brandt, Julie Marie
AU - Gregersen, Maja
AU - Sondergaard, Anne
AU - Krantz, Mette Falkenberg
AU - Knudsen, Christina Bruun
AU - Andreassen, Anna Krogh
AU - Veddum, Lotte
AU - Ohland, Jessica
AU - Hjorthoj, Carsten
AU - Wilms, Martin
AU - Rohd, Sinnika Birkehoj
AU - Greve, Aja
AU - Burton, Birgitte Klee
AU - Bliksted, Vibeke
AU - Mors, Ole
AU - Nordentoft, Merete
AU - Thorup, Anne Amalie Elgaard
AU - Hemager, Nicoline
PY - 2023
Y1 - 2023
N2 - BackgroundExposure to adversities in early childhood is associated with psychotic experiences and disorders in adulthood. We aimed to examine whether early childhood adversities are associated with middle childhood psychotic experiences in a cohort of children at familial high risk of schizophrenia (FHR-SZ), bipolar disorder (FHR-BP) and population-based controls (controls). MethodsFour hundred and forty-six children from The Danish High Risk and Resilience Study - VIA7 and VIA11 participated in this study (FHR-SZ = 170; FHR-BP = 103; controls = 173). Exposure to early childhood adversities and psychotic experiences were assessed using face-to-face interviews. Having childhood adversities assessed at baseline (age 7) was used as predictor. Psychotic experiences assessed at follow-up (age 11) were used as outcome. ResultsAcross the sample, exposure to early childhood interpersonal adversities was associated with an increased risk for any middle childhood psychotic experiences and subclinical delusions when adjusting for relevant confounders (OR 1.8, 95% CI 1.0-3.1, p = 0.05; OR 3.0, 95% CI 1.6-5.6, p < 0.001). There was no significant dose-response effect of exposure to multiple types of childhood adversities on any psychotic experiences. There were no interaction effects between early childhood adversities and FHR on middle childhood psychotic experiences. Exploratory analyses revealed that experiencing domestic violence in early childhood was associated with any middle childhood psychotic experiences (OR 2.8, 95% CI 1.5-5.1, p = 0.001). ConclusionsExposure to interpersonal adversities during early childhood is associated with an increased risk for middle childhood psychotic experiences including specifically subclinical delusions. Future studies should examine associations between exposure to childhood adversities and conversion to psychosis within this cohort.
AB - BackgroundExposure to adversities in early childhood is associated with psychotic experiences and disorders in adulthood. We aimed to examine whether early childhood adversities are associated with middle childhood psychotic experiences in a cohort of children at familial high risk of schizophrenia (FHR-SZ), bipolar disorder (FHR-BP) and population-based controls (controls). MethodsFour hundred and forty-six children from The Danish High Risk and Resilience Study - VIA7 and VIA11 participated in this study (FHR-SZ = 170; FHR-BP = 103; controls = 173). Exposure to early childhood adversities and psychotic experiences were assessed using face-to-face interviews. Having childhood adversities assessed at baseline (age 7) was used as predictor. Psychotic experiences assessed at follow-up (age 11) were used as outcome. ResultsAcross the sample, exposure to early childhood interpersonal adversities was associated with an increased risk for any middle childhood psychotic experiences and subclinical delusions when adjusting for relevant confounders (OR 1.8, 95% CI 1.0-3.1, p = 0.05; OR 3.0, 95% CI 1.6-5.6, p < 0.001). There was no significant dose-response effect of exposure to multiple types of childhood adversities on any psychotic experiences. There were no interaction effects between early childhood adversities and FHR on middle childhood psychotic experiences. Exploratory analyses revealed that experiencing domestic violence in early childhood was associated with any middle childhood psychotic experiences (OR 2.8, 95% CI 1.5-5.1, p = 0.001). ConclusionsExposure to interpersonal adversities during early childhood is associated with an increased risk for middle childhood psychotic experiences including specifically subclinical delusions. Future studies should examine associations between exposure to childhood adversities and conversion to psychosis within this cohort.
KW - Bipolar disorder
KW - childhood adversities
KW - familial high risk
KW - psychotic experiences
KW - schizophrenia
KW - TRAUMA
KW - SYMPTOMS
KW - SPECTRUM
KW - MECHANISMS
KW - PHENOTYPE
KW - DELUSIONS
KW - ONSET
U2 - 10.1017/S0033291722004020
DO - 10.1017/S0033291722004020
M3 - Journal article
C2 - 36727506
VL - 53
JO - Psychological Medicine
JF - Psychological Medicine
SN - 0033-2917
IS - 14
ER -
ID: 336291600