Psychotic experiences in seven-year-old children with familial high risk of schizophrenia or bipolar disorder in: The Danish High Risk and Resilience Study – VIA 7; A population-based cohort study
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We aimed to examine the prevalence of psychotic experiences (PEs) in children with familial high risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) and, in exploratory analyses, to examine the possible associations between PEs and mental disorders as well as level of functioning. A cohort of seven-year-old children with FHR-SZ (N = 199), FHR-BP (N = 118) and controls (N = 196) was recruited through Danish nationwide registers. Lifetime PEs were assessed through interviews using the psychosis section of the ‘Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime Version’ (K-SADS-PL). Lifetime DSM-IV diagnoses were ascertained through K-SADS-PL and the level of functioning of the children through ‘Children's Global Assessment Scale’. Both children with FHR-SZ (OR = 2.9, 95% CI = 1.4–6.2, p = 0.005) and FHR-BP (OR = 2.9, 95% CI = 1.3–6.7, p = 0.011) had an increased risk of having experienced “severe” PEs compared with controls. In the overall cohort PEs were associated with any lifetime mental disorder, Attention-Deficit/Hyperactivity Disorder, anxiety disorders and a lower level of functioning. The findings of a higher proportion of high risk children reporting PEs could represent an early manifestation of later more severe psychopathology or simply an unspecific transitory symptom. Future follow-up studies of this cohort will explore the predictive value of the occurrence of PEs at age seven.
Originalsprog | Engelsk |
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Tidsskrift | Schizophrenia Research |
Vol/bind | 228 |
Sider (fra-til) | 510-518 |
ISSN | 0920-9964 |
DOI | |
Status | Udgivet - 2021 |
Bibliografisk note
Funding Information:
This work was supported by the Mental Health Services of the Capital Region of Denmark , the Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH (Grant Nos. R102-A9118 and R155-2014-1724 ). Aarhus University , and the Beatrice Surovell Haskell Fund for Child Mental Health Research of Copenhagen (Grant No. J.NR 11531 ).
Publisher Copyright:
© 2020
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