α1-Antitrypsin deficiency causes emphysema, liver cirrhosis and hepatic cancer, and is also associated with a slightly increased risk of non-hepatic cancer.1 α1-Antitrypsin deficiency is known as a rare cause of panniculitis,2 but its relation to skin cancer is poorly described.3 We hypothesized that α1-antitrypsin deficiency is associated with increased risks of nonmelanoma and melanoma skin cancer. To test this hypothesis, we followed 2702 individuals with α1-antitrypsin deficiency and 26,750 control subjects without α1-antitrypsin deficiency matched by age, sex, and municipality in Denmark and recorded skin cancer as outcome during 62 years of follow-up