Associations Between Hypoglycemia Awareness Status and Symptoms of Hypoglycemia Among Adults with Type 1 or Insulin-Treated Type 2 Diabetes Using the Hypo-METRICS Smartphone Application
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Associations Between Hypoglycemia Awareness Status and Symptoms of Hypoglycemia Among Adults with Type 1 or Insulin-Treated Type 2 Diabetes Using the Hypo-METRICS Smartphone Application. / Martine-Edith, Gilberte; Zaremba, Natalie; Divilly, Patrick; Søholm, Uffe; Broadley, Melanie; Baumann, Petra Martina; Mahmoudi, Zeinab; Gomes, Mikel; Ali, Namam; Abbink, Evertine J.; de Galan, Bastiaan; Brøsen, Julie; Pedersen-Bjergaard, Ulrik; Vaag, Allan A.; McCrimmon, Rory J.; Renard, Eric; Heller, Simon; Evans, Mark; Cigler, Monika; Mader, Julia K.; Amiel, Stephanie A.; Speight, Jane; Pouwer, Frans; Choudhary, Pratik; for the Hypo-RESOLVE Consortium.
I: Diabetes Technology and Therapeutics, 2024.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Associations Between Hypoglycemia Awareness Status and Symptoms of Hypoglycemia Among Adults with Type 1 or Insulin-Treated Type 2 Diabetes Using the Hypo-METRICS Smartphone Application
AU - Martine-Edith, Gilberte
AU - Zaremba, Natalie
AU - Divilly, Patrick
AU - Søholm, Uffe
AU - Broadley, Melanie
AU - Baumann, Petra Martina
AU - Mahmoudi, Zeinab
AU - Gomes, Mikel
AU - Ali, Namam
AU - Abbink, Evertine J.
AU - de Galan, Bastiaan
AU - Brøsen, Julie
AU - Pedersen-Bjergaard, Ulrik
AU - Vaag, Allan A.
AU - McCrimmon, Rory J.
AU - Renard, Eric
AU - Heller, Simon
AU - Evans, Mark
AU - Cigler, Monika
AU - Mader, Julia K.
AU - Amiel, Stephanie A.
AU - Speight, Jane
AU - Pouwer, Frans
AU - Choudhary, Pratik
AU - for the Hypo-RESOLVE Consortium
N1 - Publisher Copyright: Copyright 2024, Mary Ann Liebert, Inc., publishers.
PY - 2024
Y1 - 2024
N2 - Introduction: This study examined associations between hypoglycemia awareness status and hypoglycemia symptoms reported in real-time using the novel Hypoglycaemia—MEasurement, ThResholds and ImpaCtS (Hypo-METRICS) smartphone application (app) among adults with insulin-treated type 1 (T1D) or type 2 diabetes (T2D). Methods: Adults who experienced at least one hypoglycemic episode in the previous 3 months were recruited to the Hypo-METRICS study. They prospectively reported hypoglycemia episodes using the app for 10 weeks. Any of eight hypoglycemia symptoms were considered present if intensity was rated between “A little bit” to “Very much” and absent if rated “Not at all.” Associations between hypoglycemia awareness (as defined by Gold score) and hypoglycemia symptoms were modeled using mixed-effects binary logistic regression, adjusting for glucose monitoring method and diabetes duration. Results: Of 531 participants (48% T1D, 52% T2D), 45% were women, 91% white, and 59% used Flash or continuous glucose monitoring. Impaired awareness of hypoglycemia (IAH) was associated with lower odds of reporting autonomic symptoms than normal awareness of hypoglycemia (NAH) (T1D odds ratio [OR] 0.43 [95% confidence interval {CI} 0.25-0.73], P = 0.002); T2D OR 0.51 [95% CI 0.26-0.99], P = 0.048), with no differences in neuroglycopenic symptoms. In T1D, relative to NAH, IAH was associated with higher odds of reporting autonomic symptoms at a glucose concentration <54 than >70 mg/dL (OR 2.18 [95% CI 1.21-3.94], P = 0.010). Conclusion: The Hypo-METRICS app is sensitive to differences in hypoglycemia symptoms according to hypoglycemia awareness in both diabetes types. Given its high ecological validity and low recall bias, the app may be a useful tool in research and clinical settings. The clinical trial registration number is NCT04304963.
AB - Introduction: This study examined associations between hypoglycemia awareness status and hypoglycemia symptoms reported in real-time using the novel Hypoglycaemia—MEasurement, ThResholds and ImpaCtS (Hypo-METRICS) smartphone application (app) among adults with insulin-treated type 1 (T1D) or type 2 diabetes (T2D). Methods: Adults who experienced at least one hypoglycemic episode in the previous 3 months were recruited to the Hypo-METRICS study. They prospectively reported hypoglycemia episodes using the app for 10 weeks. Any of eight hypoglycemia symptoms were considered present if intensity was rated between “A little bit” to “Very much” and absent if rated “Not at all.” Associations between hypoglycemia awareness (as defined by Gold score) and hypoglycemia symptoms were modeled using mixed-effects binary logistic regression, adjusting for glucose monitoring method and diabetes duration. Results: Of 531 participants (48% T1D, 52% T2D), 45% were women, 91% white, and 59% used Flash or continuous glucose monitoring. Impaired awareness of hypoglycemia (IAH) was associated with lower odds of reporting autonomic symptoms than normal awareness of hypoglycemia (NAH) (T1D odds ratio [OR] 0.43 [95% confidence interval {CI} 0.25-0.73], P = 0.002); T2D OR 0.51 [95% CI 0.26-0.99], P = 0.048), with no differences in neuroglycopenic symptoms. In T1D, relative to NAH, IAH was associated with higher odds of reporting autonomic symptoms at a glucose concentration <54 than >70 mg/dL (OR 2.18 [95% CI 1.21-3.94], P = 0.010). Conclusion: The Hypo-METRICS app is sensitive to differences in hypoglycemia symptoms according to hypoglycemia awareness in both diabetes types. Given its high ecological validity and low recall bias, the app may be a useful tool in research and clinical settings. The clinical trial registration number is NCT04304963.
KW - Hypo-METRICS
KW - Hypoglycemia awareness
KW - Hypoglycemia symptoms
U2 - 10.1089/dia.2023.0596
DO - 10.1089/dia.2023.0596
M3 - Journal article
C2 - 38512385
AN - SCOPUS:85190730045
JO - Diabetes Technology & Therapeutics
JF - Diabetes Technology & Therapeutics
SN - 1520-9156
ER -
ID: 389907606