Discordance in Estimated GFR Among Hospitalized Older Adults
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Discordance in Estimated GFR Among Hospitalized Older Adults. / Iversen, Esben; Andersen, Ove; Houlind, Morten Baltzer.
I: Kidney Medicine, Bind 5, Nr. 12, 100743, 2023.Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt
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TY - JOUR
T1 - Discordance in Estimated GFR Among Hospitalized Older Adults
AU - Iversen, Esben
AU - Andersen, Ove
AU - Houlind, Morten Baltzer
N1 - Funding Information: The authors declare that they have no relevant financial interests. Received September 4, 2023. Accepted September 10, 2023 after editorial review by the Editor-in Chief.
PY - 2023
Y1 - 2023
N2 - Wang et al1 evaluated discordances in the estimated glomerular filtration rate (eGFR) based on creatinine (eGFRcr), cystatin C (eGFRcys), or their combination (eGFRcr-cys). They used data from the 2021 CKD-EPI external validation cohort, which included 4,050 ambulatory participants (mean age of 57.0 years and mean measured GFR [mGFR] of 76.4 mL/min/1.73m2).2 Defining eGFRdiff as a discordance between eGFRcys and eGFRcr larger than ±15 mL/min/1.73m2, the authors found that 21% of patients had a negative discordance (eGFRcr higher) and 10% had a positive discordance (eGFRcys higher). In both groups, eGFRcr-cys yielded the best performance relative to mGFR, according to bias and P30. The authors acknowledge that their study was limited by the lack of multimorbid or hospitalized patients.
AB - Wang et al1 evaluated discordances in the estimated glomerular filtration rate (eGFR) based on creatinine (eGFRcr), cystatin C (eGFRcys), or their combination (eGFRcr-cys). They used data from the 2021 CKD-EPI external validation cohort, which included 4,050 ambulatory participants (mean age of 57.0 years and mean measured GFR [mGFR] of 76.4 mL/min/1.73m2).2 Defining eGFRdiff as a discordance between eGFRcys and eGFRcr larger than ±15 mL/min/1.73m2, the authors found that 21% of patients had a negative discordance (eGFRcr higher) and 10% had a positive discordance (eGFRcys higher). In both groups, eGFRcr-cys yielded the best performance relative to mGFR, according to bias and P30. The authors acknowledge that their study was limited by the lack of multimorbid or hospitalized patients.
U2 - 10.1016/j.xkme.2023.100743
DO - 10.1016/j.xkme.2023.100743
M3 - Letter
C2 - 38116165
AN - SCOPUS:85176960157
VL - 5
JO - Kidney Medicine
JF - Kidney Medicine
SN - 2590-0595
IS - 12
M1 - 100743
ER -
ID: 375056229