Emergence of the G118R Pan-Integrase Resistance Mutation as a Result of Low Compliance to a Dolutegravir-Based cART
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HIV-1 resistance towards integrase inhibitors is a potential threat of the success of HIV-1 combination treatment. G118R is a rare drug resistance mutation conferring pan-integrase resistance. Here, we describe the occurrence of G118R in a HIV-1 subtype-B-positive individual with major compliance problems, detected while the patient was on dolutegravir-based cART. We speculate the pre-selection of M184I/V aided the occurrence of G118R in this case, and discuss the robustness of dolutegravir-based therapies.
Originalsprog | Engelsk |
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Tidsskrift | Infectious Disease Reports |
Vol/bind | 14 |
Udgave nummer | 4 |
Sider (fra-til) | 501-504 |
ISSN | 2036-7430 |
DOI | |
Status | Udgivet - 2022 |
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© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
ID: 324815316