The Human Leukocyte Antigen-G 3'UTR 14-bp Deletion is Associated with Poor Survival in an HIV-1-infected Zimbabwean Population
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
We aimed to evaluate if the HLA-G 14-bp polymorphism (rs16375) has an impact on HIV progression and survival in an antiretroviral therapy (ART)-naïve Zimbabwean cohort (n=312). Rs16375 was genotyped using a competitive allele-specific PCR system; CD4 cell counts and HIV RNA were measured by flow cytometry and commercially available PCR; survival was followed for 4.3 years. The homozygous HLA-G -14-bp genotype is associated with higher viral load (P=0.004), lower CD4 cell count (P=0.01), and increased mortality (hazard ratio=1.9, CI: 1.033-3.522; P=0.04) compared with HLA-G +14-bp carriers.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Infectious Diseases |
Vol/bind | 207 |
Udgave nummer | 6 |
Sider (fra-til) | 903-06 |
ISSN | 0022-1899 |
DOI | |
Status | Udgivet - 2013 |
ID: 48451426