Quantitative aortography for assessment of aortic regurgitation in the era of percutaneous aortic valve replacement

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  • Mahmoud Abdelshafy
  • Patrick W. Serruys
  • Tsung Ying Tsai
  • Pruthvi Chenniganahosahalli Revaiah
  • Scot Garg
  • Jean Paul Aben
  • Carl J. Schultz
  • Mohammad Abdelghani
  • Pim A.L. Tonino
  • Yosuke Miyazaki
  • Marcel C.M. Rutten
  • Martijn Cox
  • Cherif Sahyoun
  • Justin Teng
  • Hiroki Tateishi
  • Mohamed Abdel-Wahab
  • Nicolo Piazza
  • Michele Pighi
  • Rodrigo Modolo
  • Martijn van Mourik
  • Joanna Wykrzykowska
  • Robbert J. de Winter
  • Pedro A. Lemos
  • Fábio S. de Brito
  • Hideyuki Kawashima
  • Liesbeth Rosseel
  • Rutao Wang
  • Chao Gao
  • Ling Tao
  • Andreas Rück
  • Won Keun Kim
  • Niels van Royen
  • Christian J. Terkelsen
  • Henrik Nissen
  • Matti Adam
  • Tanja K. Rudolph
  • Hendrik Wienemann
  • Ryo Torii
  • Franz Josef Neuman
  • Simon Schoechlin
  • Mao Chen
  • Ahmed Elkoumy
  • Hesham Elzomor
  • Ignacio J. Amat-Santos
  • Darren Mylotte
  • Osama Soliman
  • Yoshinobu Onuma

Paravalvular leak (PVL) is a shortcoming that can erode the clinical benefits of transcatheter valve replacement (TAVR) and therefore a readily applicable method (aortography) to quantitate PVL objectively and accurately in the interventional suite is appealing to all operators. The ratio between the areas of the time-density curves in the aorta and left ventricular outflow tract (LVOT-AR) defines the regurgitation fraction (RF). This technique has been validated in a mock circulation; a single injection in diastole was further tested in porcine and ovine models. In the clinical setting, LVOT-AR was compared with trans-thoracic and trans-oesophageal echocardiography and cardiac magnetic resonance imaging. LVOT-AR > 17% discriminates mild from moderate aortic regurgitation on echocardiography and confers a poor prognosis in multiple registries, and justifies balloon post-dilatation. The LVOT-AR differentiates the individual performances of many old and novel devices and is being used in ongoing randomized trials and registries.

OriginalsprogEngelsk
Artikelnummer1161779
TidsskriftFrontiers in Cardiovascular Medicine
Vol/bind10
Antal sider15
ISSN2297-055X
DOI
StatusUdgivet - 2023

Bibliografisk note

Publisher Copyright:
2023 Abdelshafy, Serruys, Tsai, Revaiah, Grag, Aben, Schultz, Abdelghani, Tonino, Miyazaki, Rutten, Cox, Sahyoun, Teng, Tateishi, Abdel-Wahab, Piazza, Pighi, Modolo, van Mourik, Wykrzykowska, de Wintet, Lemos, de Brito, Kawashima, Søendergaard, Rosseel, Wang, Gao, Tao, Rück, Kim, van Royen, Terkelsen, Nissen, Adam, Rudolph, Wienemann, Torii, Neuman, Schoechlin, Chen, Elkoumy, Elzomor, Amat-Santos, Mylotte, Soliman and Onuma.

ID: 363063944