In patients with atrial fibrillation (AF) and increased risk of stroke, oral anticoagulation (OAC) is the standard treatment for stroke prevention - however, this therapy also carries a high risk of bleeding. Percutaneous closure of the left atrial appendage (LAA) has been suggested to be an alternative option for stroke prevention in AF patients with contraindication(s) for OAC treatment. In this paper, we discuss the rationale for LAA closure, the importance of a proper patient selection, as well as some pre- and post-procedural issues.