BKPyV DNAemia in Kidney Transplant Recipients Undergoing Regular Screening: A Single-Centre Cohort Study
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BKPyV DNAemia in Kidney Transplant Recipients Undergoing Regular Screening : A Single-Centre Cohort Study. / Rasmussen, Daniel B.; Møller, Dina L.; Hamm, Sebastian R.; Borges, Álvaro H.; Nielsen, Alex C.Y.; Kirkby, Nikolai S.; Sørensen, Søren S.; Nielsen, Susanne D.
I: Microorganisms, Bind 12, Nr. 1, 65, 2024.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - BKPyV DNAemia in Kidney Transplant Recipients Undergoing Regular Screening
T2 - A Single-Centre Cohort Study
AU - Rasmussen, Daniel B.
AU - Møller, Dina L.
AU - Hamm, Sebastian R.
AU - Borges, Álvaro H.
AU - Nielsen, Alex C.Y.
AU - Kirkby, Nikolai S.
AU - Sørensen, Søren S.
AU - Nielsen, Susanne D.
N1 - Publisher Copyright: © 2023 by the authors.
PY - 2024
Y1 - 2024
N2 - Infection with BK polyomavirus (BKPyV) is a common opportunistic infection after kidney transplantation (KT) and may affect graft function. We aimed to determine the incidence, risk factors, and clinical outcomes of BKPyV DNAemia in a prospective cohort of 601 KT recipients transplanted from 2012 to 2020. BKPyV PCR on plasma was performed at days 60, 90, 180, 270, and 360 post-KT. Any BKPyV DNAemia was defined as a single BKPyV DNA of ≥1000 copies/mL. Severe BKPyV DNAemia was defined as two consecutive BKPyV DNA of ≥10,000 copies/mL. Cumulative incidences were investigated using the Aalen–Johansen estimator, and the risk factors were investigated in Cox proportional hazard models. The incidence of any BKPyV DNAemia and severe BKPyV DNAemia was 21% (18–25) and 13% (10–16) at one year post-KT, respectively. Recipient age > 50 years (aHR, 1.72; 95% CI 1.00–2.94; p = 0.049), male sex (aHR, 1.96; 95% CI 1.17–3.29; p = 0.011), living donors (aHR, 1.65; 95% CI 1.03–2.74; p = 0.045), and >3 HLA-ABDR mismatches (aHR, 1.72; 95% CI 1.01–2.94; p = 0.046) increased the risk of severe BKPyV DNAemia. Any BKPyV DNAemia was associated with an increased risk of graft function decline (aHR, 2.26; 95% CI 1.00–5.12; p = 0.049), and severe BKPyV DNAemia was associated with an increased risk of graft loss (aHR, 3.18; 95% CI 1.06–9.58; p = 0.039). These findings highlight the importance of BKPyV monitoring post-KT.
AB - Infection with BK polyomavirus (BKPyV) is a common opportunistic infection after kidney transplantation (KT) and may affect graft function. We aimed to determine the incidence, risk factors, and clinical outcomes of BKPyV DNAemia in a prospective cohort of 601 KT recipients transplanted from 2012 to 2020. BKPyV PCR on plasma was performed at days 60, 90, 180, 270, and 360 post-KT. Any BKPyV DNAemia was defined as a single BKPyV DNA of ≥1000 copies/mL. Severe BKPyV DNAemia was defined as two consecutive BKPyV DNA of ≥10,000 copies/mL. Cumulative incidences were investigated using the Aalen–Johansen estimator, and the risk factors were investigated in Cox proportional hazard models. The incidence of any BKPyV DNAemia and severe BKPyV DNAemia was 21% (18–25) and 13% (10–16) at one year post-KT, respectively. Recipient age > 50 years (aHR, 1.72; 95% CI 1.00–2.94; p = 0.049), male sex (aHR, 1.96; 95% CI 1.17–3.29; p = 0.011), living donors (aHR, 1.65; 95% CI 1.03–2.74; p = 0.045), and >3 HLA-ABDR mismatches (aHR, 1.72; 95% CI 1.01–2.94; p = 0.046) increased the risk of severe BKPyV DNAemia. Any BKPyV DNAemia was associated with an increased risk of graft function decline (aHR, 2.26; 95% CI 1.00–5.12; p = 0.049), and severe BKPyV DNAemia was associated with an increased risk of graft loss (aHR, 3.18; 95% CI 1.06–9.58; p = 0.039). These findings highlight the importance of BKPyV monitoring post-KT.
KW - BK viremia
KW - BKPyV DNAemia
KW - cohort study
KW - graft function
KW - graft loss
KW - immunosuppression
KW - kidney transplant
KW - opportunistic infection
U2 - 10.3390/microorganisms12010065
DO - 10.3390/microorganisms12010065
M3 - Journal article
C2 - 38257892
AN - SCOPUS:85183153590
VL - 12
JO - Microorganisms
JF - Microorganisms
SN - 2076-2607
IS - 1
M1 - 65
ER -
ID: 381849657