Background: Long-term outcomes after acute medical and surgical illness are largely unknown. Aim: To describe cognitive and physical function, health-related quality of life and risk of anxiety and depression after acute illness. Design: Prospective cohort study. Methods:Homevisitatthreeandtwelvemonthsmeasuring:RepeatableBatteryfortheAssessmentofNeuropsychological Status (RBANS), Chelsea Critical Care Physical Assessment tool, Short Form Health Survey, Hospital Anxiety and Depression Scale and Trail Making Test. Results: Of 101 included patients, 60 were visited at three and 36 at twelve months. The RBANS value was 84 (69-96) at three months and 88 (69-101) at twelve months. Conclusions: We found a moderately reduced cognitive function three and twelve months after acute illness.