Peptidylglycine α-amidating monooxygenase and adrenomedullin measurement in patients with hepatic cirrhosis
Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt
Background: Peptidylglycine α-amidating monooxygenase (PAM) is an enzyme involved in the maturation of regulatory peptides. Here we examined PAM activity and adrenomedullin (bio-ADM) concentrations in patients with hepatic cirrhosis and determined net changes across the liver, kidneys and leg. Materials and methods: A total of 48 patients with hepatic cirrhosis and 16 control subjects were included. All patients and controls underwent an invasive procedure with blood collected across organs. Results: PAM activity was increased in cirrhotic patients but without a net change across the liver, leg or kidney. In contrast, bio-ADM concentrations were associated with severity of disease and found to be higher in venous blood from the liver. Conclusion: Increased PAM activity in patients with hepatic cirrhosis may reflect other organs involved in cirrhotic disease.
Originalsprog | Engelsk |
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Tidsskrift | Biomarkers in Medicine |
Vol/bind | 17 |
Udgave nummer | 13 |
Sider (fra-til) | 577-583 |
Antal sider | 7 |
ISSN | 1752-0363 |
DOI | |
Status | Udgivet - 2023 |
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