2B4 expression on natural killer cells increases in HIV-1 infected patients followed prospectively during highly active antiretroviral therapy

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Standard

2B4 expression on natural killer cells increases in HIV-1 infected patients followed prospectively during highly active antiretroviral therapy. / Ostrowski, S R; Ullum, H; Pedersen, Bente Klarlund; Gerstoft, J; Katzenstein, T L.

I: Clinical and Experimental Immunology, Bind 141, Nr. 3, 09.2005, s. 526-33.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Ostrowski, SR, Ullum, H, Pedersen, BK, Gerstoft, J & Katzenstein, TL 2005, '2B4 expression on natural killer cells increases in HIV-1 infected patients followed prospectively during highly active antiretroviral therapy', Clinical and Experimental Immunology, bind 141, nr. 3, s. 526-33. https://doi.org/10.1111/j.1365-2249.2005.02869.x

APA

Ostrowski, S. R., Ullum, H., Pedersen, B. K., Gerstoft, J., & Katzenstein, T. L. (2005). 2B4 expression on natural killer cells increases in HIV-1 infected patients followed prospectively during highly active antiretroviral therapy. Clinical and Experimental Immunology, 141(3), 526-33. https://doi.org/10.1111/j.1365-2249.2005.02869.x

Vancouver

Ostrowski SR, Ullum H, Pedersen BK, Gerstoft J, Katzenstein TL. 2B4 expression on natural killer cells increases in HIV-1 infected patients followed prospectively during highly active antiretroviral therapy. Clinical and Experimental Immunology. 2005 sep.;141(3):526-33. https://doi.org/10.1111/j.1365-2249.2005.02869.x

Author

Ostrowski, S R ; Ullum, H ; Pedersen, Bente Klarlund ; Gerstoft, J ; Katzenstein, T L. / 2B4 expression on natural killer cells increases in HIV-1 infected patients followed prospectively during highly active antiretroviral therapy. I: Clinical and Experimental Immunology. 2005 ; Bind 141, Nr. 3. s. 526-33.

Bibtex

@article{bcb072c955284527baa852fd9e81ec43,
title = "2B4 expression on natural killer cells increases in HIV-1 infected patients followed prospectively during highly active antiretroviral therapy",
abstract = "Human immunodeficiency virus (HIV)-1 infection influences natural killer (NK) cell expression of inhibitory NK receptors and activating natural cytotoxicity receptors. It is unknown whether expression of the co-stimulatory NK cell receptor 2B4 (CD244) on NK cells and CD3+ CD8+ cells are affected by highly active antiretroviral therapy (HAART), low-level viraemia, proviral-DNA or immune activation in HIV-1 infected patients. A total of 101 HAART-treated HIV-1 infected patients with < or = 200 HIV-RNA copies/ml were followed prospectively for 24 months. HIV-RNA was investigated 3-monthly and 2B4 expression on CD3- CD16+ NK cells and CD3+ CD8+ cells, proviral-DNA and plasma soluble tumour necrosis factor receptor (sTNFr)-II were investigated 6-monthly. For comparison, 2B4 expression was investigated in 20 healthy individuals. The concentration of 2B4+ NK cells was initially reduced in HIV-1 infected patients (P < 0.001) but increased to a normal level during the 24 months' follow-up. The concentration of CD3+ CD8+ 2B4+ cells in HIV-1 infected patients was normal and did not change during follow-up. The relative fluorescence intensity (RFI) of 2B4 increased on both NK cells and CD3+ CD8+ cells during follow-up (both P < 0.001). Higher levels of proviral-DNA carrying cells and plasma sTNFrII were associated with reductions in the concentration of 2B4+ NK cells (all P < 0.05). HIV-RNA had no effect on 2B4 expression on NK cells or CD3+ CD8+ cells. These findings demonstrate that the concentration of 2B4+ NK cells normalizes during long-term HAART in HIV-1 infected patients. The finding that proviral-DNA and sTNFrII were associated negatively with the concentration of 2B4+ NK cells suggests that immune activation in HIV-1 infected patients receiving HAART influences the target cell recognition by NK cells.",
keywords = "Adult, Aged, Anti-HIV Agents, Antigens, CD, Antiretroviral Therapy, Highly Active, CD8-Positive T-Lymphocytes, Case-Control Studies, Female, Flow Cytometry, HIV Infections, HIV-1, Humans, Killer Cells, Natural, Male, Membrane Glycoproteins, Middle Aged, Models, Statistical, Prospective Studies, Receptors, Immunologic, Receptors, Tumor Necrosis Factor, Signaling Lymphocytic Activation Molecule Family, Viral Load, Journal Article, Research Support, Non-U.S. Gov't",
author = "Ostrowski, {S R} and H Ullum and Pedersen, {Bente Klarlund} and J Gerstoft and Katzenstein, {T L}",
year = "2005",
month = sep,
doi = "10.1111/j.1365-2249.2005.02869.x",
language = "English",
volume = "141",
pages = "526--33",
journal = "Clinical and Experimental Immunology",
issn = "0009-9104",
publisher = "Wiley",
number = "3",

}

RIS

TY - JOUR

T1 - 2B4 expression on natural killer cells increases in HIV-1 infected patients followed prospectively during highly active antiretroviral therapy

AU - Ostrowski, S R

AU - Ullum, H

AU - Pedersen, Bente Klarlund

AU - Gerstoft, J

AU - Katzenstein, T L

PY - 2005/9

Y1 - 2005/9

N2 - Human immunodeficiency virus (HIV)-1 infection influences natural killer (NK) cell expression of inhibitory NK receptors and activating natural cytotoxicity receptors. It is unknown whether expression of the co-stimulatory NK cell receptor 2B4 (CD244) on NK cells and CD3+ CD8+ cells are affected by highly active antiretroviral therapy (HAART), low-level viraemia, proviral-DNA or immune activation in HIV-1 infected patients. A total of 101 HAART-treated HIV-1 infected patients with < or = 200 HIV-RNA copies/ml were followed prospectively for 24 months. HIV-RNA was investigated 3-monthly and 2B4 expression on CD3- CD16+ NK cells and CD3+ CD8+ cells, proviral-DNA and plasma soluble tumour necrosis factor receptor (sTNFr)-II were investigated 6-monthly. For comparison, 2B4 expression was investigated in 20 healthy individuals. The concentration of 2B4+ NK cells was initially reduced in HIV-1 infected patients (P < 0.001) but increased to a normal level during the 24 months' follow-up. The concentration of CD3+ CD8+ 2B4+ cells in HIV-1 infected patients was normal and did not change during follow-up. The relative fluorescence intensity (RFI) of 2B4 increased on both NK cells and CD3+ CD8+ cells during follow-up (both P < 0.001). Higher levels of proviral-DNA carrying cells and plasma sTNFrII were associated with reductions in the concentration of 2B4+ NK cells (all P < 0.05). HIV-RNA had no effect on 2B4 expression on NK cells or CD3+ CD8+ cells. These findings demonstrate that the concentration of 2B4+ NK cells normalizes during long-term HAART in HIV-1 infected patients. The finding that proviral-DNA and sTNFrII were associated negatively with the concentration of 2B4+ NK cells suggests that immune activation in HIV-1 infected patients receiving HAART influences the target cell recognition by NK cells.

AB - Human immunodeficiency virus (HIV)-1 infection influences natural killer (NK) cell expression of inhibitory NK receptors and activating natural cytotoxicity receptors. It is unknown whether expression of the co-stimulatory NK cell receptor 2B4 (CD244) on NK cells and CD3+ CD8+ cells are affected by highly active antiretroviral therapy (HAART), low-level viraemia, proviral-DNA or immune activation in HIV-1 infected patients. A total of 101 HAART-treated HIV-1 infected patients with < or = 200 HIV-RNA copies/ml were followed prospectively for 24 months. HIV-RNA was investigated 3-monthly and 2B4 expression on CD3- CD16+ NK cells and CD3+ CD8+ cells, proviral-DNA and plasma soluble tumour necrosis factor receptor (sTNFr)-II were investigated 6-monthly. For comparison, 2B4 expression was investigated in 20 healthy individuals. The concentration of 2B4+ NK cells was initially reduced in HIV-1 infected patients (P < 0.001) but increased to a normal level during the 24 months' follow-up. The concentration of CD3+ CD8+ 2B4+ cells in HIV-1 infected patients was normal and did not change during follow-up. The relative fluorescence intensity (RFI) of 2B4 increased on both NK cells and CD3+ CD8+ cells during follow-up (both P < 0.001). Higher levels of proviral-DNA carrying cells and plasma sTNFrII were associated with reductions in the concentration of 2B4+ NK cells (all P < 0.05). HIV-RNA had no effect on 2B4 expression on NK cells or CD3+ CD8+ cells. These findings demonstrate that the concentration of 2B4+ NK cells normalizes during long-term HAART in HIV-1 infected patients. The finding that proviral-DNA and sTNFrII were associated negatively with the concentration of 2B4+ NK cells suggests that immune activation in HIV-1 infected patients receiving HAART influences the target cell recognition by NK cells.

KW - Adult

KW - Aged

KW - Anti-HIV Agents

KW - Antigens, CD

KW - Antiretroviral Therapy, Highly Active

KW - CD8-Positive T-Lymphocytes

KW - Case-Control Studies

KW - Female

KW - Flow Cytometry

KW - HIV Infections

KW - HIV-1

KW - Humans

KW - Killer Cells, Natural

KW - Male

KW - Membrane Glycoproteins

KW - Middle Aged

KW - Models, Statistical

KW - Prospective Studies

KW - Receptors, Immunologic

KW - Receptors, Tumor Necrosis Factor

KW - Signaling Lymphocytic Activation Molecule Family

KW - Viral Load

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1111/j.1365-2249.2005.02869.x

DO - 10.1111/j.1365-2249.2005.02869.x

M3 - Journal article

C2 - 16045743

VL - 141

SP - 526

EP - 533

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

SN - 0009-9104

IS - 3

ER -

ID: 180571273