Alterations in osteoclast function and phenotype induced by different inhibitors of bone resorption--implications for osteoclast quality
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Normal osteoclasts resorb bone by secretion of acid and proteases. Recent studies of patients with loss of function mutations affecting either of these processes have indicated a divergence in osteoclastic phenotypes. These difference in osteoclast phenotypes may directly or indirectly have secondary effects on bone remodeling, a process which is of importance for the pathogenesis of both osteoporosis and osteoarthritis. We treated human osteoclasts with different inhibitors and characterized their resulting function.
Originalsprog | Engelsk |
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Tidsskrift | B M C Musculoskeletal Disorders |
Vol/bind | 11 |
Sider (fra-til) | 109 |
ISSN | 1471-2474 |
DOI | |
Status | Udgivet - 1 jan. 2010 |
ID: 34184481