Schistosomiasis and infection with human immunodeficiency virus 1 in rural Zimbabwe: systemic inflammation during co-infection and after treatment for schistosomiasis
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Schistosomiasis and infection with human immunodeficiency virus 1 in rural Zimbabwe : systemic inflammation during co-infection and after treatment for schistosomiasis. / Erikstrup, Christian; Kallestrup, Per; Zinyama-Gutsire, Rutendo B L; Gomo, Exnevia; van Dam, Govert J; Deelder, André M.; Butterworth, Anthony E; Pedersen, Bente Klarlund; Ostrowski, Sisse R; Gerstoft, Jan; Ullum, Henrik.
I: American Journal of Tropical Medicine and Hygiene, Bind 79, Nr. 3, 09.2008, s. 331-7.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Schistosomiasis and infection with human immunodeficiency virus 1 in rural Zimbabwe
T2 - systemic inflammation during co-infection and after treatment for schistosomiasis
AU - Erikstrup, Christian
AU - Kallestrup, Per
AU - Zinyama-Gutsire, Rutendo B L
AU - Gomo, Exnevia
AU - van Dam, Govert J
AU - Deelder, André M.
AU - Butterworth, Anthony E
AU - Pedersen, Bente Klarlund
AU - Ostrowski, Sisse R
AU - Gerstoft, Jan
AU - Ullum, Henrik
PY - 2008/9
Y1 - 2008/9
N2 - We previously reported that treatment for schistosomiasis in persons infected with human immunodeficiency virus 1 (HIV-1) attenuated HIV replication as measured by plasma HIV RNA. We investigated systemic inflammation as measured by plasma levels of soluble tumor necrosis factor-alpha receptor II (sTNF-rII), interleukin-8, (IL-8), and IL-10 during schistosomiasis and HIV co-infection and after schistosomiasis treatment. The cohort was composed of 378 persons who were or were not infected with HIV-1, Schistosoma haematobium, or S. mansoni. Schistosomiasis-infected persons were randomized to receive praziquantel (40 mg/kg) at baseline or at the three-month follow-up. sTNF-rII and IL-8 were positively associated with schistosomiasis intensity as measured by circulating anodic antigen (CAA), regardless of HIV status. Interleukin-10 was positively associated with CAA in HIV-negative participants. IL-8 levels were higher in S. mansoni-infected individuals. Treatment for schistosomiasis caused a decrease in levels of sTNF-rII (P < 0.05) and IL-10 (P < 0.001). Our results indicate that schistosomiasis treatment may attenuate HIV replication by decreasing systemic inflammation.
AB - We previously reported that treatment for schistosomiasis in persons infected with human immunodeficiency virus 1 (HIV-1) attenuated HIV replication as measured by plasma HIV RNA. We investigated systemic inflammation as measured by plasma levels of soluble tumor necrosis factor-alpha receptor II (sTNF-rII), interleukin-8, (IL-8), and IL-10 during schistosomiasis and HIV co-infection and after schistosomiasis treatment. The cohort was composed of 378 persons who were or were not infected with HIV-1, Schistosoma haematobium, or S. mansoni. Schistosomiasis-infected persons were randomized to receive praziquantel (40 mg/kg) at baseline or at the three-month follow-up. sTNF-rII and IL-8 were positively associated with schistosomiasis intensity as measured by circulating anodic antigen (CAA), regardless of HIV status. Interleukin-10 was positively associated with CAA in HIV-negative participants. IL-8 levels were higher in S. mansoni-infected individuals. Treatment for schistosomiasis caused a decrease in levels of sTNF-rII (P < 0.05) and IL-10 (P < 0.001). Our results indicate that schistosomiasis treatment may attenuate HIV replication by decreasing systemic inflammation.
KW - Adolescent
KW - Adult
KW - Cohort Studies
KW - Cross-Sectional Studies
KW - Cytokines
KW - Female
KW - HIV Infections
KW - HIV-1
KW - Humans
KW - Inflammation
KW - Interleukin-10
KW - Interleukin-8
KW - Male
KW - Middle Aged
KW - Praziquantel
KW - Receptors, Tumor Necrosis Factor, Type II
KW - Schistosomiasis
KW - Schistosomicides
KW - Zimbabwe
KW - Journal Article
KW - Randomized Controlled Trial
KW - Research Support, Non-U.S. Gov't
KW - Research Support, U.S. Gov't, P.H.S.
M3 - Journal article
C2 - 18784223
VL - 79
SP - 331
EP - 337
JO - Journal. National Malaria Society
JF - Journal. National Malaria Society
SN - 0002-9637
IS - 3
ER -
ID: 180571072