High serum levels of YKL-40 in patients with squamous cell carcinoma of the head and neck are associated with short survival
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YKL-40 is a glycoprotein secreted by macrophages, neutrophils and malignant tumor cells. Elevated serum levels of YKL-40 are associated with poor prognosis in several malignancies. In this study, we examined the prognostic value of serum YKL-40 before treatment and during follow-up in patients with squamous cell carcinoma of the head and neck (HNSCC). YKL-40 was determined by ELISA retrospectively in serum from 173 patients with primary HNSCC before treatment and up to 2 years after treatment. Median follow-up time was 7.9 years. YKL-40 protein expression in tumor biopsies was assessed by immunohistochemistry in 50 patients. Pretreatment serum YKL-40 was elevated in 53%. Patients with high serum YKL-40 had shorter survival than patients with normal serum YKL-40 (33 vs. 84 months; p = 0.008). Multivariate Cox analysis including pretreatment serum YKL-40, age, sex, primary tumor site, TNM classification and treatment demonstrated that TNM classification (HR = 2.61, p = 0.02) and serum YKL-40 (log-transformed continuous variable: HR = 1.55, p < 0.0001) were independent prognostic variables of overall survival (OS). Multivariate Cox analysis demonstrated that TNM classification (HR = 5.77, p = 0.001) and serum YKL-40 (dichotomous variable: HR = 2.75, p = 0.01) were independent predictors of recurrence-free survival. During follow-up after radiotherapy, a high serum YKL-40 (log-transformed continuous variable) in patients with TNM Stage III and TV disease predicted poorer OS within 6 months (HR = 1.95, p < 0.0001). Immunohistochemical analysis showed YKL-40 expression in the malignant tumor cells. In conclusion, serum YKL-40 was demonstrated to be an independent prognostic biomarker of recurrence-free and overall survival in patients with HNSCC. (C) 2007 Wiley-Liss, Inc
Udgivelsesdato: 2008/2/15
Udgivelsesdato: 2008/2/15
Originalsprog | Engelsk |
---|---|
Tidsskrift | International Journal of Cancer |
Vol/bind | 122 |
Udgave nummer | 4 |
Sider (fra-til) | 857-863 |
Antal sider | 6 |
ISSN | 0020-7136 |
Status | Udgivet - 2008 |
Bibliografisk note
Times Cited: 0ArticleEnglishRoslind, AUniv Copenhagen, Herlev Hosp, Dept Oncol, Herlev Ringvej 75, DK-2730 Herlev, DenmarkCited References Count: 48253MQWILEY-LISSDIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USAHOBOKEN
ID: 10951279