Patient and Tumour Characteristics of Adult Head and Neck Soft Tissue Sarcomas: A Systematic Review and Meta-Analysis
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Patient and Tumour Characteristics of Adult Head and Neck Soft Tissue Sarcomas : A Systematic Review and Meta-Analysis. / Andersen, Sakshi; Mann, Henriette; Krarup-Hansen, Anders; Lajer, Christel Bræmer; Grønhøj, Christian.
I: Sarcoma, Bind 2019, 9725637, 05.2019.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Patient and Tumour Characteristics of Adult Head and Neck Soft Tissue Sarcomas
T2 - A Systematic Review and Meta-Analysis
AU - Andersen, Sakshi
AU - Mann, Henriette
AU - Krarup-Hansen, Anders
AU - Lajer, Christel Bræmer
AU - Grønhøj, Christian
PY - 2019/5
Y1 - 2019/5
N2 - Background. Head and neck soft tissue sarcomas (HNSTS) constitute a rare and heterogeneous cancer entity. Management remains a challenge due to the rarity and varied biological behaviour among various subtypes. This systematic review examines the characteristics of tumours and patients with HNSTS. Materials and Methods. A systematic literature review and meta-analysis were performed using the electronic databases PubMed and Embase. Eight eligible studies were identified, and 13 variables were extracted from each study including 5-year overall survival (OS) rate and 5-year disease-free survival (DFS) rate. Results. We identified eight studies (n = 1,120 patients; 739 males (66%)) from six different countries). In total, 24 histological subtypes were found, and 20% of the sarcomas (n = 215) could not be subclassified. 607 sarcomas (57%) were <5 cm in diameter, and 945 sarcomas (84%) were grade 3. 1,059 patients (90%) underwent surgery. Estimated 5-year OS was 74% (95% CI; 0.63-0.84%) and 5-year DFS was 56% (95% CI; 38-74%). Conclusion. HNSTS holds a relative poor prognosis possibly explained by the heterogeneity of the disease. Treatment of HNSTS has shown to be highly diverse, underlining the importance of uniformed treatment guidelines in order to achieve improved survival outcomes.
AB - Background. Head and neck soft tissue sarcomas (HNSTS) constitute a rare and heterogeneous cancer entity. Management remains a challenge due to the rarity and varied biological behaviour among various subtypes. This systematic review examines the characteristics of tumours and patients with HNSTS. Materials and Methods. A systematic literature review and meta-analysis were performed using the electronic databases PubMed and Embase. Eight eligible studies were identified, and 13 variables were extracted from each study including 5-year overall survival (OS) rate and 5-year disease-free survival (DFS) rate. Results. We identified eight studies (n = 1,120 patients; 739 males (66%)) from six different countries). In total, 24 histological subtypes were found, and 20% of the sarcomas (n = 215) could not be subclassified. 607 sarcomas (57%) were <5 cm in diameter, and 945 sarcomas (84%) were grade 3. 1,059 patients (90%) underwent surgery. Estimated 5-year OS was 74% (95% CI; 0.63-0.84%) and 5-year DFS was 56% (95% CI; 38-74%). Conclusion. HNSTS holds a relative poor prognosis possibly explained by the heterogeneity of the disease. Treatment of HNSTS has shown to be highly diverse, underlining the importance of uniformed treatment guidelines in order to achieve improved survival outcomes.
U2 - 10.1155/2019/9725637
DO - 10.1155/2019/9725637
M3 - Review
C2 - 31263380
AN - SCOPUS:85066976996
VL - 2019
JO - Sarcoma
JF - Sarcoma
SN - 1357-714X
M1 - 9725637
ER -
ID: 240984247