Pemetrexed safety and pharmacokinetics in patients with third-space fluid
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Pemetrexed safety and pharmacokinetics in patients with third-space fluid. / Dickgreber, Nicolas J; Sørensen, Jens Benn; Paz-Ares, Luis G; Schytte, Tine Kjestrup; Latz, Jane E; Schneck, Karen B; Zheng, Yuan; Sanchez-Torres, José Miguel.
I: Clinical Cancer Research, Bind 16, Nr. 10, 15.05.2010, s. 2872-80.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Pemetrexed safety and pharmacokinetics in patients with third-space fluid
AU - Dickgreber, Nicolas J
AU - Sørensen, Jens Benn
AU - Paz-Ares, Luis G
AU - Schytte, Tine Kjestrup
AU - Latz, Jane E
AU - Schneck, Karen B
AU - Zheng, Yuan
AU - Sanchez-Torres, José Miguel
N1 - Copyright (c) 2010 AACR.
PY - 2010/5/15
Y1 - 2010/5/15
N2 - Pemetrexed is established as first-line treatment with cisplatin for malignant pleural mesothelioma and advanced nonsquamous non-small-cell lung cancer (NSCLC) and as single-agent second-line treatment for nonsquamous NSCLC. Because the structure and pharmacokinetics of pemetrexed are similar to those of methotrexate, and methotrexate is associated with severe toxicity in patients with third-space fluid (TSF), the safety of pemetrexed in patients with TSF was evaluated.
AB - Pemetrexed is established as first-line treatment with cisplatin for malignant pleural mesothelioma and advanced nonsquamous non-small-cell lung cancer (NSCLC) and as single-agent second-line treatment for nonsquamous NSCLC. Because the structure and pharmacokinetics of pemetrexed are similar to those of methotrexate, and methotrexate is associated with severe toxicity in patients with third-space fluid (TSF), the safety of pemetrexed in patients with TSF was evaluated.
U2 - http://dx.doi.org/10.1158/1078-0432.CCR-09-3324
DO - http://dx.doi.org/10.1158/1078-0432.CCR-09-3324
M3 - Journal article
VL - 16
SP - 2872
EP - 2880
JO - Clinical Cancer Research
JF - Clinical Cancer Research
SN - 1078-0432
IS - 10
ER -
ID: 34097115