Application of advanced brain positron emission tomography–based molecular imaging for a biological framework in neurodegenerative proteinopathies
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Dokumenter
- Perani_et_al-2019-Alzheimer's_&_Dementia__Diagnosis,_Assessment_&_Disease_Monitoring
Forlagets udgivne version, 296 KB, PDF-dokument
Introduction: A rapid transition from a clinical-based classification to a pathology-based classification of neurodegenerative conditions, largely promoted by the increasing availability of imaging biomarkers, is emerging. The Framework for Innovative Multi-tracer molecular Brain Imaging, funded by the EU Joint Program - Neurodegenerative Disease Research 2016 “Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration,” aimed at providing a roadmap for the applications of established and new molecular imaging techniques in dementia. Methods: We consider current and future implications of adopting a pathology-based framework for the use and development of positron emission tomography techniques. Results: This approach will enhance efforts to understand the multifactorial etiology of Alzheimer's disease and other dementias. Discussion: The availability of pathology biomarkers will soon transform clinical and research practice. Crucially, a comprehensive understanding of strengths and caveats of these techniques will promote an informed use to take full advantage of these tools.
Originalsprog | Engelsk |
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Tidsskrift | Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring |
Vol/bind | 11 |
Sider (fra-til) | 327-332 |
Antal sider | 6 |
ISSN | 2352-8729 |
DOI | |
Status | Udgivet - 1 dec. 2019 |
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