Debate: Are cluster headache and migraine distinct headache disorders?

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  • Mohammad Al Mahdi Al-Karagholi
  • Kuan-Po Peng
  • Anja Sofie Petersen
  • Irene De Boer
  • Gisela M. Terwindt
  • dlt446, dlt446

Cluster headache and migraine are regarded as distinct primary headaches. While cluster headache and migraine differ in multiple aspects such as gender-related and headache specific features (e.g., attack duration and frequency), both show clinical similarities in trigger factors (e.g., alcohol) and treatment response (e.g., triptans). Here, we review the similarities and differences in anatomy and pathophysiology that underlie cluster headache and migraine, discuss whether cluster headache and migraine should indeed be considered as two distinct primary headaches, and propose recommendations for future studies. Graphical Abstract: Video recording of the debate held at the 1st International Conference on Advances in Migraine Sciences (ICAMS 2022, Copenhagen, Denmark) is available at https://www.youtube.com/watch?v=uUimmnDVTTE.[Figure not available: see fulltext.]

OriginalsprogEngelsk
Artikelnummer151
TidsskriftJournal of Headache and Pain
Vol/bind23
Antal sider13
ISSN1129-2369
DOI
StatusUdgivet - 2022

Bibliografisk note

Funding Information:
MMK, KPP, ASP and IDB report no conflict of interest. GMT has received consulting fees and honoraria for lectures/presentations from Allergan, Eli Lily, Lundbeck, Novartis and Teva. Personal fees from AbbVie/Allergan, Amgen, Eli Lilly, Lundbeck, Novartis, Pfizer and Teva. MA participated in clinical trials as the principal investigator for AbbVie/Allergan, Amgen, Eli Lilly, Lundbeck, Novartis and Teva. MA received a research grant (institutional) from Lundbeck Foundation, Novo Nordisk Foundation, Novartis. MA has no ownership interest and does not own stocks of any pharmaceutical company. MA serves as associate editor of Cephalalgia, associate editor of the Journal of Headache and Pain, and associate editor of Brain.

Funding Information:
The Research Fund of Rigshospitalet (E-23327-04). The Lundbeck Foundation for supporting the study through the Professor Grant (R310–2018-3711).

Publisher Copyright:
© 2022, The Author(s).

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