Early stopping in clinical PET studies: How to reduce expense and exposure
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Clinical positron emission tomography (PET) research is costly and entails exposing participants to radioactivity. Researchers should therefore aim to include just the number of subjects needed to fulfill the purpose of the study. In this tutorial we show how to apply sequential Bayes Factor testing in order to stop the recruitment of subjects in a clinical PET study as soon as enough data have been collected to make a conclusion. By using simulations, we demonstrate that it is possible to stop a study early, while keeping the number of erroneous conclusions low. We then apply sequential Bayes Factor testing to a real PET data set and show that it is possible to obtain support in favor of an effect while simultaneously reducing the sample size with 30%. Using this procedure allows researchers to reduce expense and radioactivity exposure for a range of effect sizes relevant for PET research.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Cerebral Blood Flow and Metabolism |
Vol/bind | 41 |
Udgave nummer | 11 |
Sider (fra-til) | 2805-2819 |
ISSN | 0271-678X |
DOI | |
Status | Udgivet - 2021 |
Bibliografisk note
Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Lundbeck Foundation and the Swedish Society for Medical Research.
Publisher Copyright:
© The Author(s) 2021.
ID: 272236593