Neural Substrates of Psychotic Depression: Findings from the Global ECT-MRI Research Collaboration

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Neural Substrates of Psychotic Depression : Findings from the Global ECT-MRI Research Collaboration. / Takamiya, Akihiro; Dols, Annemiek; Emsell, Louise; Abbott, Christopher; Yrondi, Antoine; Soriano Mas, Carles; Jorgensen, Martin Balslev; Nordanskog, Pia; Rhebergen, Didi; Van Exel, Eric; Oudega, Mardien L.; Bouckaert, Filip; Vandenbulcke, Mathieu; Sienaert, Pascal; Peran, Patrice; Cano, Marta; Cardoner, Narcis; Jorgensen, Anders; Paulson, Olaf B.; Hamilton, Paul; Kampe, Robin; Bruin, Willem; Bartsch, Hauke; Ousdal, Olga Therese; Kessler, Ute; Van Wingen, Guido; Oltedal, Leif; Kishimoto, Taishiro.

I: Schizophrenia Bulletin, Bind 48, Nr. 2, 2022, s. 514-523.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Takamiya, A, Dols, A, Emsell, L, Abbott, C, Yrondi, A, Soriano Mas, C, Jorgensen, MB, Nordanskog, P, Rhebergen, D, Van Exel, E, Oudega, ML, Bouckaert, F, Vandenbulcke, M, Sienaert, P, Peran, P, Cano, M, Cardoner, N, Jorgensen, A, Paulson, OB, Hamilton, P, Kampe, R, Bruin, W, Bartsch, H, Ousdal, OT, Kessler, U, Van Wingen, G, Oltedal, L & Kishimoto, T 2022, 'Neural Substrates of Psychotic Depression: Findings from the Global ECT-MRI Research Collaboration', Schizophrenia Bulletin, bind 48, nr. 2, s. 514-523. https://doi.org/10.1093/schbul/sbab122

APA

Takamiya, A., Dols, A., Emsell, L., Abbott, C., Yrondi, A., Soriano Mas, C., Jorgensen, M. B., Nordanskog, P., Rhebergen, D., Van Exel, E., Oudega, M. L., Bouckaert, F., Vandenbulcke, M., Sienaert, P., Peran, P., Cano, M., Cardoner, N., Jorgensen, A., Paulson, O. B., ... Kishimoto, T. (2022). Neural Substrates of Psychotic Depression: Findings from the Global ECT-MRI Research Collaboration. Schizophrenia Bulletin, 48(2), 514-523. https://doi.org/10.1093/schbul/sbab122

Vancouver

Takamiya A, Dols A, Emsell L, Abbott C, Yrondi A, Soriano Mas C o.a. Neural Substrates of Psychotic Depression: Findings from the Global ECT-MRI Research Collaboration. Schizophrenia Bulletin. 2022;48(2):514-523. https://doi.org/10.1093/schbul/sbab122

Author

Takamiya, Akihiro ; Dols, Annemiek ; Emsell, Louise ; Abbott, Christopher ; Yrondi, Antoine ; Soriano Mas, Carles ; Jorgensen, Martin Balslev ; Nordanskog, Pia ; Rhebergen, Didi ; Van Exel, Eric ; Oudega, Mardien L. ; Bouckaert, Filip ; Vandenbulcke, Mathieu ; Sienaert, Pascal ; Peran, Patrice ; Cano, Marta ; Cardoner, Narcis ; Jorgensen, Anders ; Paulson, Olaf B. ; Hamilton, Paul ; Kampe, Robin ; Bruin, Willem ; Bartsch, Hauke ; Ousdal, Olga Therese ; Kessler, Ute ; Van Wingen, Guido ; Oltedal, Leif ; Kishimoto, Taishiro. / Neural Substrates of Psychotic Depression : Findings from the Global ECT-MRI Research Collaboration. I: Schizophrenia Bulletin. 2022 ; Bind 48, Nr. 2. s. 514-523.

Bibtex

@article{41f4063e182d4c0c870d997edbaaf5da,
title = "Neural Substrates of Psychotic Depression: Findings from the Global ECT-MRI Research Collaboration",
abstract = "Psychotic major depression (PMD) is hypothesized to be a distinct clinical entity from nonpsychotic major depression (NPMD). However, neurobiological evidence supporting this notion is scarce. The aim of this study is to identify gray matter volume (GMV) differences between PMD and NPMD and their longitudinal change following electroconvulsive therapy (ECT). Structural magnetic resonance imaging (MRI) data from 8 independent sites in the Global ECT-MRI Research Collaboration (GEMRIC) database (n = 108; 56 PMD and 52 NPMD; mean age 71.7 in PMD and 70.2 in NPMD) were analyzed. All participants underwent MRI before and after ECT. First, cross-sectional whole-brain voxel-wise GMV comparisons between PMD and NPMD were conducted at both time points. Second, in a flexible factorial model, a main effect of time and a group-by-time interaction were examined to identify longitudinal effects of ECT on GMV and longitudinal differential effects of ECT between PMD and NPMD, respectively. Compared with NPMD, PMD showed lower GMV in the prefrontal, temporal and parietal cortex before ECT; PMD showed lower GMV in the medial prefrontal cortex (MPFC) after ECT. Although there was a significant main effect of time on GMV in several brain regions in both PMD and NPMD, there was no significant group-by-time interaction. Lower GMV in the MPFC was consistently identified in PMD, suggesting this may be a trait-like neural substrate of PMD. Longitudinal effect of ECT on GMV may not explain superior ECT response in PMD, and further investigation is needed. ",
keywords = "Depression, Gray matter volume, Magnetic resonance imaging, Medial prefrontal cortex, Psychosis",
author = "Akihiro Takamiya and Annemiek Dols and Louise Emsell and Christopher Abbott and Antoine Yrondi and {Soriano Mas}, Carles and Jorgensen, {Martin Balslev} and Pia Nordanskog and Didi Rhebergen and {Van Exel}, Eric and Oudega, {Mardien L.} and Filip Bouckaert and Mathieu Vandenbulcke and Pascal Sienaert and Patrice Peran and Marta Cano and Narcis Cardoner and Anders Jorgensen and Paulson, {Olaf B.} and Paul Hamilton and Robin Kampe and Willem Bruin and Hauke Bartsch and Ousdal, {Olga Therese} and Ute Kessler and {Van Wingen}, Guido and Leif Oltedal and Taishiro Kishimoto",
note = "Publisher Copyright: {\textcopyright} 2021 The Author(s). Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.",
year = "2022",
doi = "10.1093/schbul/sbab122",
language = "English",
volume = "48",
pages = "514--523",
journal = "Schizophrenia Bulletin",
issn = "0586-7614",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Neural Substrates of Psychotic Depression

T2 - Findings from the Global ECT-MRI Research Collaboration

AU - Takamiya, Akihiro

AU - Dols, Annemiek

AU - Emsell, Louise

AU - Abbott, Christopher

AU - Yrondi, Antoine

AU - Soriano Mas, Carles

AU - Jorgensen, Martin Balslev

AU - Nordanskog, Pia

AU - Rhebergen, Didi

AU - Van Exel, Eric

AU - Oudega, Mardien L.

AU - Bouckaert, Filip

AU - Vandenbulcke, Mathieu

AU - Sienaert, Pascal

AU - Peran, Patrice

AU - Cano, Marta

AU - Cardoner, Narcis

AU - Jorgensen, Anders

AU - Paulson, Olaf B.

AU - Hamilton, Paul

AU - Kampe, Robin

AU - Bruin, Willem

AU - Bartsch, Hauke

AU - Ousdal, Olga Therese

AU - Kessler, Ute

AU - Van Wingen, Guido

AU - Oltedal, Leif

AU - Kishimoto, Taishiro

N1 - Publisher Copyright: © 2021 The Author(s). Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.

PY - 2022

Y1 - 2022

N2 - Psychotic major depression (PMD) is hypothesized to be a distinct clinical entity from nonpsychotic major depression (NPMD). However, neurobiological evidence supporting this notion is scarce. The aim of this study is to identify gray matter volume (GMV) differences between PMD and NPMD and their longitudinal change following electroconvulsive therapy (ECT). Structural magnetic resonance imaging (MRI) data from 8 independent sites in the Global ECT-MRI Research Collaboration (GEMRIC) database (n = 108; 56 PMD and 52 NPMD; mean age 71.7 in PMD and 70.2 in NPMD) were analyzed. All participants underwent MRI before and after ECT. First, cross-sectional whole-brain voxel-wise GMV comparisons between PMD and NPMD were conducted at both time points. Second, in a flexible factorial model, a main effect of time and a group-by-time interaction were examined to identify longitudinal effects of ECT on GMV and longitudinal differential effects of ECT between PMD and NPMD, respectively. Compared with NPMD, PMD showed lower GMV in the prefrontal, temporal and parietal cortex before ECT; PMD showed lower GMV in the medial prefrontal cortex (MPFC) after ECT. Although there was a significant main effect of time on GMV in several brain regions in both PMD and NPMD, there was no significant group-by-time interaction. Lower GMV in the MPFC was consistently identified in PMD, suggesting this may be a trait-like neural substrate of PMD. Longitudinal effect of ECT on GMV may not explain superior ECT response in PMD, and further investigation is needed.

AB - Psychotic major depression (PMD) is hypothesized to be a distinct clinical entity from nonpsychotic major depression (NPMD). However, neurobiological evidence supporting this notion is scarce. The aim of this study is to identify gray matter volume (GMV) differences between PMD and NPMD and their longitudinal change following electroconvulsive therapy (ECT). Structural magnetic resonance imaging (MRI) data from 8 independent sites in the Global ECT-MRI Research Collaboration (GEMRIC) database (n = 108; 56 PMD and 52 NPMD; mean age 71.7 in PMD and 70.2 in NPMD) were analyzed. All participants underwent MRI before and after ECT. First, cross-sectional whole-brain voxel-wise GMV comparisons between PMD and NPMD were conducted at both time points. Second, in a flexible factorial model, a main effect of time and a group-by-time interaction were examined to identify longitudinal effects of ECT on GMV and longitudinal differential effects of ECT between PMD and NPMD, respectively. Compared with NPMD, PMD showed lower GMV in the prefrontal, temporal and parietal cortex before ECT; PMD showed lower GMV in the medial prefrontal cortex (MPFC) after ECT. Although there was a significant main effect of time on GMV in several brain regions in both PMD and NPMD, there was no significant group-by-time interaction. Lower GMV in the MPFC was consistently identified in PMD, suggesting this may be a trait-like neural substrate of PMD. Longitudinal effect of ECT on GMV may not explain superior ECT response in PMD, and further investigation is needed.

KW - Depression

KW - Gray matter volume

KW - Magnetic resonance imaging

KW - Medial prefrontal cortex

KW - Psychosis

U2 - 10.1093/schbul/sbab122

DO - 10.1093/schbul/sbab122

M3 - Journal article

C2 - 34624103

AN - SCOPUS:85125553668

VL - 48

SP - 514

EP - 523

JO - Schizophrenia Bulletin

JF - Schizophrenia Bulletin

SN - 0586-7614

IS - 2

ER -

ID: 310433287