Disrupted eye movements in preperimetric primary open-angle glaucoma
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Disrupted eye movements in preperimetric primary open-angle glaucoma. / Najjar, Raymond P.; Sharma, Sourabh; Drouet, Morgane; Leruez, Stephanie; Baskaran, Mani; Nongpiur, Monisha E.; Aung, Tin; Fielding, Joanne; White, Owen; Girard, Michael J.; Lamirel, Cédric; Milea, Dan.
I: Investigative Ophthalmology and Visual Science, Bind 58, Nr. 4, 2017, s. 2430-2437.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Disrupted eye movements in preperimetric primary open-angle glaucoma
AU - Najjar, Raymond P.
AU - Sharma, Sourabh
AU - Drouet, Morgane
AU - Leruez, Stephanie
AU - Baskaran, Mani
AU - Nongpiur, Monisha E.
AU - Aung, Tin
AU - Fielding, Joanne
AU - White, Owen
AU - Girard, Michael J.
AU - Lamirel, Cédric
AU - Milea, Dan
PY - 2017
Y1 - 2017
N2 - PURPOSE. Primary open-angle glaucoma (POAG) can be associated with abnormal ocular motor behavior, possibly as a compensatory strategy following visual field loss. The aim of this study was to explore the characteristics of saccadic eye movements in patients with early-stage POAG without any detectable glaucomatous visual field loss (i.e., preperimetric POAG). METHODS. Binocular eye movements were explored in 16 patients with bilateral preperimetric POAG and 16 age-matched healthy controls in a cross-sectional, observational study. Visually guided horizontal prosaccades (58, 108, 158, and 208 amplitude) and antisaccades (128 amplitude) were measured using infrared oculography. The latency, average and peak velocities, amplitude and gain of prosaccades as well as the percentage of errors in the antisaccades task were compared between groups. RESULTS. POAG patients exhibited a reduced average velocity of saccades compared to controls across all amplitudes of peripheral visual target presentation (P = 0.03). Saccades performed by POAG patients were hypometric, and with reduced amplitude (P = 0.007) and gain (P = 0.01) compared to controls. On average, POAG patients displayed more antisaccade errors (40.6%), as compared to controls (23.4%; P = 0.04). CONCLUSIONS. Here, we show that patients with POAG without detectable glaucomatous visual field loss exhibit altered saccadic eye movements. These abnormalities may indicate disordered cortical and subcortical saccadic regulation, either on the basis of subthreshold visual impairment, or as a result of wider disease-associated neurodegeneration. Additional studies, controlling for glaucoma medications, are required to delineate the neural basis of eye movement abnormalities associated with POAG.
AB - PURPOSE. Primary open-angle glaucoma (POAG) can be associated with abnormal ocular motor behavior, possibly as a compensatory strategy following visual field loss. The aim of this study was to explore the characteristics of saccadic eye movements in patients with early-stage POAG without any detectable glaucomatous visual field loss (i.e., preperimetric POAG). METHODS. Binocular eye movements were explored in 16 patients with bilateral preperimetric POAG and 16 age-matched healthy controls in a cross-sectional, observational study. Visually guided horizontal prosaccades (58, 108, 158, and 208 amplitude) and antisaccades (128 amplitude) were measured using infrared oculography. The latency, average and peak velocities, amplitude and gain of prosaccades as well as the percentage of errors in the antisaccades task were compared between groups. RESULTS. POAG patients exhibited a reduced average velocity of saccades compared to controls across all amplitudes of peripheral visual target presentation (P = 0.03). Saccades performed by POAG patients were hypometric, and with reduced amplitude (P = 0.007) and gain (P = 0.01) compared to controls. On average, POAG patients displayed more antisaccade errors (40.6%), as compared to controls (23.4%; P = 0.04). CONCLUSIONS. Here, we show that patients with POAG without detectable glaucomatous visual field loss exhibit altered saccadic eye movements. These abnormalities may indicate disordered cortical and subcortical saccadic regulation, either on the basis of subthreshold visual impairment, or as a result of wider disease-associated neurodegeneration. Additional studies, controlling for glaucoma medications, are required to delineate the neural basis of eye movement abnormalities associated with POAG.
KW - Antisaccades
KW - Eye movements
KW - Infrared oculography
KW - Preperimetric
KW - Primary open-angle glaucoma
KW - Prosaccades
U2 - 10.1167/iovs.16-21002
DO - 10.1167/iovs.16-21002
M3 - Journal article
C2 - 28448671
AN - SCOPUS:85019080082
VL - 58
SP - 2430
EP - 2437
JO - Investigative Ophthalmology & Visual Science
JF - Investigative Ophthalmology & Visual Science
SN - 0146-0404
IS - 4
ER -
ID: 196716801