Steroid Response after Trabeculectomy—A Randomized Controlled Trial Comparing Dexamethasone to Diclofenac Eye Drops
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This prospective randomized controlled trial aimed to compare changes in intraocular pressure in three different anti-inflammatory regimens following trabeculectomy. Sixty-nine patients were randomized to receive either postoperative prophylaxis with topical preservative-free dexamethasone (DEX), diclofenac (DICLO), or their combination (DEX+DICLO). Our main outcome measure was an intraocular pressure (IOP) change of a minimum 4 mmHg following the withdrawal of anti-inflammatory prophylaxis 9 weeks after trabeculectomy. We found that the IOP decreased ≥ 4 mmHg in 18.6% of eyes after cessation of the topical steroid DEX (n = 3/22) and DEX+DICLO (n = 5/21), whereas a decrease in IOP was not observed in the DICLO group. In conclusion, IOP decreased in nearly 1/5 of patients after cessation of topical steroidal anti-inflammatory prophylaxis after trabeculectomy. This points toward a steroid-induced increase in IOP even after trabeculectomy. Thus, increased postoperative IOP may be related to steroid use, and the success or failure of a trabeculectomy cannot be fully evaluated before anti-inflammatory prophylaxis with steroids is stopped or changed to non-steroidal eye drops.
Originalsprog | Engelsk |
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Artikelnummer | 7365 |
Tidsskrift | Journal of Clinical Medicine |
Vol/bind | 11 |
Udgave nummer | 24 |
ISSN | 2077-0383 |
DOI | |
Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:
This research was funded by Fight for Sight Denmark, the Danish Eye Research Foundation, the Synoptik Foundation, the Gangsted Fond, the Fabrikant Einar Willumsens Fond, the Aase og Ejnar Danielsens Fond and the Henry og Astrid Møllers Fond. Funding organizations had no role in the design or conduct of this research.
Publisher Copyright:
© 2022 by the authors.
ID: 340405474