Physical capacity in children and adolescents with newly diagnosed cancer: A systematic review and meta-analysis
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Physical capacity in children and adolescents with newly diagnosed cancer : A systematic review and meta-analysis. / Schmidt-Andersen, Peter; Stage, Anna; Pouplier, Anna; Bastholm, Louise H.; Müller, Klaus G.; Larsen, Anders; Ness, Kirsten K.; Larsen, Hanne B.; Christensen, Jan; Fridh, Martin K.
I: Pediatric Blood and Cancer, Bind 71, Nr. 1, e30746, 2024.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Physical capacity in children and adolescents with newly diagnosed cancer
T2 - A systematic review and meta-analysis
AU - Schmidt-Andersen, Peter
AU - Stage, Anna
AU - Pouplier, Anna
AU - Bastholm, Louise H.
AU - Müller, Klaus G.
AU - Larsen, Anders
AU - Ness, Kirsten K.
AU - Larsen, Hanne B.
AU - Christensen, Jan
AU - Fridh, Martin K.
N1 - Publisher Copyright: © 2023 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals LLC.
PY - 2024
Y1 - 2024
N2 - Objective: To review the body of evidence on cardiorespiratory fitness, muscle strength, and physical performance in children with newly diagnosed cancer, five databases (MEDLINE, Embase, CINAHL, CENTRAL, and Web of Science) were searched on December 19, 2022. Methods: Thirteen studies, embodying 594 participants within 1 month of cancer diagnosis and 3674 healthy controls were included. Eighteen different outcomes on cardiorespiratory fitness (n = 2), muscle strength (n = 5), physical performance (n = 10), and adverse events (n = 1) were analyzed. Results: Fifteen out of 17 outcomes on physical capacity showed severe impairments compared with healthy controls. Where possible, random-effects meta-analysis was conducted to synthesize the results. No adverse events were reported related to testing. Conclusion: Children with cancer have impaired cardiorespiratory fitness, muscle strength, and physical performance within the first month after diagnosis. However, the evidence is based on a small number of studies with large clinical heterogeneity, limiting the certainty of evidence.
AB - Objective: To review the body of evidence on cardiorespiratory fitness, muscle strength, and physical performance in children with newly diagnosed cancer, five databases (MEDLINE, Embase, CINAHL, CENTRAL, and Web of Science) were searched on December 19, 2022. Methods: Thirteen studies, embodying 594 participants within 1 month of cancer diagnosis and 3674 healthy controls were included. Eighteen different outcomes on cardiorespiratory fitness (n = 2), muscle strength (n = 5), physical performance (n = 10), and adverse events (n = 1) were analyzed. Results: Fifteen out of 17 outcomes on physical capacity showed severe impairments compared with healthy controls. Where possible, random-effects meta-analysis was conducted to synthesize the results. No adverse events were reported related to testing. Conclusion: Children with cancer have impaired cardiorespiratory fitness, muscle strength, and physical performance within the first month after diagnosis. However, the evidence is based on a small number of studies with large clinical heterogeneity, limiting the certainty of evidence.
KW - cardiorespiratory fitness
KW - muscle strength
KW - pediatric exercise oncology
KW - physical performance
U2 - 10.1002/pbc.30746
DO - 10.1002/pbc.30746
M3 - Review
C2 - 37877893
AN - SCOPUS:85174708204
VL - 71
JO - Medical and Pediatric Oncology. Supplement
JF - Medical and Pediatric Oncology. Supplement
SN - 0740-8226
IS - 1
M1 - e30746
ER -
ID: 377983629