Sex-specifics of ECT outcome
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Sex-specifics of ECT outcome. / Blanken, M. A.J.T.; Oudega, M. L.; Hoogendoorn, A. W.; Sonnenberg, C. S.; Rhebergen, D.; Klumpers, U. M.H.; Van Diermen, L.; Birkenhager, T.; Schrijvers, D.; Redlich, R.; Dannlowski, U.; Heindel, W.; Coenjaerts, M.; Nordanskog, P.; Oltedal, L.; Kessler, U.; Frid, L. M.; Takamiya, A.; Kishimoto, T.; Jorgensen, M. B.; Jorgensen, A.; Bolwig, T.; Emsell, L.; Sienaert, P.; Bouckaert, F.; Abbott, C. C.; Péran, P.; Arbus, C.; Yrondi, A.; Kiebs, M.; Philipsen, A.; van Waarde, J. A.; Prinsen, E.; van Verseveld, M.; Van Wingen, G.; ten Doesschate, F.; Camprodon, J. A.; Kritzer, M.; Barbour, T.; Argyelan, M.; Cardoner, N.; Urretavizcaya, M.; Soriano-Mas, C.; Narr, K. L.; Espinoza, R. T.; Prudic, J.; Rowny, S.; van Eijndhoven, Ph; Tendolkar, I.; Dols, A.
I: Journal of Affective Disorders, Bind 326, 2023, s. 243-248.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Sex-specifics of ECT outcome
AU - Blanken, M. A.J.T.
AU - Oudega, M. L.
AU - Hoogendoorn, A. W.
AU - Sonnenberg, C. S.
AU - Rhebergen, D.
AU - Klumpers, U. M.H.
AU - Van Diermen, L.
AU - Birkenhager, T.
AU - Schrijvers, D.
AU - Redlich, R.
AU - Dannlowski, U.
AU - Heindel, W.
AU - Coenjaerts, M.
AU - Nordanskog, P.
AU - Oltedal, L.
AU - Kessler, U.
AU - Frid, L. M.
AU - Takamiya, A.
AU - Kishimoto, T.
AU - Jorgensen, M. B.
AU - Jorgensen, A.
AU - Bolwig, T.
AU - Emsell, L.
AU - Sienaert, P.
AU - Bouckaert, F.
AU - Abbott, C. C.
AU - Péran, P.
AU - Arbus, C.
AU - Yrondi, A.
AU - Kiebs, M.
AU - Philipsen, A.
AU - van Waarde, J. A.
AU - Prinsen, E.
AU - van Verseveld, M.
AU - Van Wingen, G.
AU - ten Doesschate, F.
AU - Camprodon, J. A.
AU - Kritzer, M.
AU - Barbour, T.
AU - Argyelan, M.
AU - Cardoner, N.
AU - Urretavizcaya, M.
AU - Soriano-Mas, C.
AU - Narr, K. L.
AU - Espinoza, R. T.
AU - Prudic, J.
AU - Rowny, S.
AU - van Eijndhoven, Ph
AU - Tendolkar, I.
AU - Dols, A.
N1 - Publisher Copyright: © 2022
PY - 2023
Y1 - 2023
N2 - Objective: Electroconvulsive therapy (ECT) is the most effective treatment for patients with severe major depressive disorder (MDD). Given the known sex differences in MDD, improved knowledge may provide more sex-specific recommendations in clinical guidelines and improve outcome. In the present study we examine sex differences in ECT outcome and its predictors. Methods: Clinical data from 20 independent sites participating in the Global ECT-MRI Research Collaboration (GEMRIC) were obtained for analysis, totaling 500 patients with MDD (58.6 % women) with a mean age of 54.8 years. Severity of depression before and after ECT was assessed with validated depression scales. Remission was defined as a HAM-D score of 7 points or below after ECT. Variables associated with remission were selected based on literature (i.e. depression severity at baseline, age, duration of index episode, and presence of psychotic symptoms). Results: Remission rates of ECT were independent of sex, 48.0 % in women and 45.7 % in men (X2(1) = 0.2, p = 0.70). In the logistic regression analyses, a shorter index duration was identified as a sex-specific predictor for ECT outcome in women (X2(1) = 7.05, p = 0.01). The corresponding predictive margins did show overlapping confidence intervals for men and women. Conclusion: The evidence provided by our study suggests that ECT as a biological treatment for MDD is equally effective in women and men. A shorter duration of index episode was an additional sex- specific predictor for remission in women. Future research should establish whether the confidence intervals for the corresponding predictive margins are overlapping, as we find, or not.
AB - Objective: Electroconvulsive therapy (ECT) is the most effective treatment for patients with severe major depressive disorder (MDD). Given the known sex differences in MDD, improved knowledge may provide more sex-specific recommendations in clinical guidelines and improve outcome. In the present study we examine sex differences in ECT outcome and its predictors. Methods: Clinical data from 20 independent sites participating in the Global ECT-MRI Research Collaboration (GEMRIC) were obtained for analysis, totaling 500 patients with MDD (58.6 % women) with a mean age of 54.8 years. Severity of depression before and after ECT was assessed with validated depression scales. Remission was defined as a HAM-D score of 7 points or below after ECT. Variables associated with remission were selected based on literature (i.e. depression severity at baseline, age, duration of index episode, and presence of psychotic symptoms). Results: Remission rates of ECT were independent of sex, 48.0 % in women and 45.7 % in men (X2(1) = 0.2, p = 0.70). In the logistic regression analyses, a shorter index duration was identified as a sex-specific predictor for ECT outcome in women (X2(1) = 7.05, p = 0.01). The corresponding predictive margins did show overlapping confidence intervals for men and women. Conclusion: The evidence provided by our study suggests that ECT as a biological treatment for MDD is equally effective in women and men. A shorter duration of index episode was an additional sex- specific predictor for remission in women. Future research should establish whether the confidence intervals for the corresponding predictive margins are overlapping, as we find, or not.
KW - ECT
KW - Electroconvulsive therapy
KW - Major depressive disorder
KW - Phenotype
KW - Predictor
KW - Sex
KW - Sex-specific
UR - http://www.scopus.com/inward/record.url?scp=85147573003&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2022.12.144
DO - 10.1016/j.jad.2022.12.144
M3 - Journal article
C2 - 36632848
AN - SCOPUS:85147573003
VL - 326
SP - 243
EP - 248
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
ER -
ID: 370733645