Volume of the Human Hippocampus and Clinical Response Following Electroconvulsive Therapy
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Volume of the Human Hippocampus and Clinical Response Following Electroconvulsive Therapy. / Oltedal, Leif; Narr, Katherine L; Abbott, Christopher; Anand, Amit; Argyelan, Miklos; Bartsch, Hauke; Dannlowski, Udo; Dols, Annemieke; van Eijndhoven, Philip; Emsell, Louise; Erchinger, Vera Jane; Espinoza, Randall; Hahn, Tim; Hanson, Lars G; Hellemann, Gerhard; Jorgensen, Martin Balslev; Kessler, Ute; Oudega, Mardien L; Paulson, Olaf B; Redlich, Ronny; Sienaert, Pascal; Stek, Max L; Tendolkar, Indira; Vandenbulcke, Mathieu; Oedegaard, Ketil J; Dale, Anders M.
I: Biological Psychiatry, Bind 84, Nr. 8, 2018, s. 574-581.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Volume of the Human Hippocampus and Clinical Response Following Electroconvulsive Therapy
AU - Oltedal, Leif
AU - Narr, Katherine L
AU - Abbott, Christopher
AU - Anand, Amit
AU - Argyelan, Miklos
AU - Bartsch, Hauke
AU - Dannlowski, Udo
AU - Dols, Annemieke
AU - van Eijndhoven, Philip
AU - Emsell, Louise
AU - Erchinger, Vera Jane
AU - Espinoza, Randall
AU - Hahn, Tim
AU - Hanson, Lars G
AU - Hellemann, Gerhard
AU - Jorgensen, Martin Balslev
AU - Kessler, Ute
AU - Oudega, Mardien L
AU - Paulson, Olaf B
AU - Redlich, Ronny
AU - Sienaert, Pascal
AU - Stek, Max L
AU - Tendolkar, Indira
AU - Vandenbulcke, Mathieu
AU - Oedegaard, Ketil J
AU - Dale, Anders M
N1 - Copyright © 2018 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
PY - 2018
Y1 - 2018
N2 - BACKGROUND: Hippocampal enlargements are commonly reported after electroconvulsive therapy (ECT). To clarify mechanisms, we examined if ECT-induced hippocampal volume change relates to dose (number of ECT sessions and electrode placement) and acts as a biomarker of clinical outcome.METHODS: Longitudinal neuroimaging and clinical data from 10 independent sites participating in the Global ECT-Magnetic Resonance Imaging Research Collaboration (GEMRIC) were obtained for mega-analysis. Hippocampal volumes were extracted from structural magnetic resonance images, acquired before and after patients (n = 281) experiencing a major depressive episode completed an ECT treatment series using right unilateral and bilateral stimulation. Untreated nondepressed control subjects (n = 95) were scanned twice.RESULTS: The linear component of hippocampal volume change was 0.28% (SE 0.08) per ECT session (p < .001). Volume change varied by electrode placement in the left hippocampus (bilateral, 3.3 ± 2.2%, d = 1.5; right unilateral, 1.6 ± 2.1%, d = 0.8; p < .0001) but not the right hippocampus (bilateral, 3.0 ± 1.7%, d = 1.8; right unilateral, 2.7 ± 2.0%, d = 1.4; p = .36). Volume change for electrode placement per ECT session varied similarly by hemisphere. Individuals with greater treatment-related volume increases had poorer outcomes (Montgomery-Åsberg Depression Rating Scale change -1.0 [SE 0.35], per 1% volume increase, p = .005), although the effects were not significant after controlling for ECT number (slope -0.69 [SE 0.38], p = .069).CONCLUSIONS: The number of ECT sessions and electrode placement impacts the extent and laterality of hippocampal enlargement, but volume change is not positively associated with clinical outcome. The results suggest that the high efficacy of ECT is not explained by hippocampal enlargement, which alone might not serve as a viable biomarker for treatment outcome.
AB - BACKGROUND: Hippocampal enlargements are commonly reported after electroconvulsive therapy (ECT). To clarify mechanisms, we examined if ECT-induced hippocampal volume change relates to dose (number of ECT sessions and electrode placement) and acts as a biomarker of clinical outcome.METHODS: Longitudinal neuroimaging and clinical data from 10 independent sites participating in the Global ECT-Magnetic Resonance Imaging Research Collaboration (GEMRIC) were obtained for mega-analysis. Hippocampal volumes were extracted from structural magnetic resonance images, acquired before and after patients (n = 281) experiencing a major depressive episode completed an ECT treatment series using right unilateral and bilateral stimulation. Untreated nondepressed control subjects (n = 95) were scanned twice.RESULTS: The linear component of hippocampal volume change was 0.28% (SE 0.08) per ECT session (p < .001). Volume change varied by electrode placement in the left hippocampus (bilateral, 3.3 ± 2.2%, d = 1.5; right unilateral, 1.6 ± 2.1%, d = 0.8; p < .0001) but not the right hippocampus (bilateral, 3.0 ± 1.7%, d = 1.8; right unilateral, 2.7 ± 2.0%, d = 1.4; p = .36). Volume change for electrode placement per ECT session varied similarly by hemisphere. Individuals with greater treatment-related volume increases had poorer outcomes (Montgomery-Åsberg Depression Rating Scale change -1.0 [SE 0.35], per 1% volume increase, p = .005), although the effects were not significant after controlling for ECT number (slope -0.69 [SE 0.38], p = .069).CONCLUSIONS: The number of ECT sessions and electrode placement impacts the extent and laterality of hippocampal enlargement, but volume change is not positively associated with clinical outcome. The results suggest that the high efficacy of ECT is not explained by hippocampal enlargement, which alone might not serve as a viable biomarker for treatment outcome.
U2 - 10.1016/j.biopsych.2018.05.017
DO - 10.1016/j.biopsych.2018.05.017
M3 - Journal article
C2 - 30006199
VL - 84
SP - 574
EP - 581
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 8
ER -
ID: 221265635