Association between MRI findings and patient-reported outcomes in patients with rheumatoid arthritis in clinical remission and at relapse
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Association between MRI findings and patient-reported outcomes in patients with rheumatoid arthritis in clinical remission and at relapse. / Glinatsi, Daniel; Brahe, Cecilie H.; Hetland, Merete L.; Ørnbjerg, Lykke; Krabbe, Simon; Baker, Joshua F.; Boesen, Mikael; Rastiemadabadi, Zoreh; Morsel-Carlsen, Lone; Røgind, Henrik; Hansen, Annette; Nørregaard, Jesper; Jacobsen, Søren; Terslev, Lene; Huynh, Tuan K.; Manilo, Natalia; Jensen, Dorte V.; Møller, Jakob M.; Krogh, Niels S.; Østergaard, Mikkel.
I: International Journal of Rheumatic Diseases, Bind 23, Nr. 4, 2020, s. 488-498.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Association between MRI findings and patient-reported outcomes in patients with rheumatoid arthritis in clinical remission and at relapse
AU - Glinatsi, Daniel
AU - Brahe, Cecilie H.
AU - Hetland, Merete L.
AU - Ørnbjerg, Lykke
AU - Krabbe, Simon
AU - Baker, Joshua F.
AU - Boesen, Mikael
AU - Rastiemadabadi, Zoreh
AU - Morsel-Carlsen, Lone
AU - Røgind, Henrik
AU - Hansen, Annette
AU - Nørregaard, Jesper
AU - Jacobsen, Søren
AU - Terslev, Lene
AU - Huynh, Tuan K.
AU - Manilo, Natalia
AU - Jensen, Dorte V.
AU - Møller, Jakob M.
AU - Krogh, Niels S.
AU - Østergaard, Mikkel
PY - 2020
Y1 - 2020
N2 - Objective: To investigate whether magnetic resonance imaging (MRI) pathologies in the wrist/hand of rheumatoid arthritis (RA) patients are associated with patient-reported outcomes (PROs) at clinical remission and relapse. Methods: Wrist/hand MRIs and wrists/hands/feet radiographs were obtained in 114 established RA patients in clinical remission, before tapering their biologic disease-modifying antirheumatic drugs. MRIs were assessed according to the Outcome Measures in Rheumatology (OMERACT) RA MRI score (RAMRIS) for inflammation (synovitis/tenosynovitis/bone marrow edema) and damage (bone erosion/joint space narrowing) at baseline (ie remission) and in case of a relapse (n = 70). Radiographs were assessed according to the Sharp/van der Heijde (SvH) method at baseline. These scores were assessed for associations with health assessment questionnaires (HAQ), visual analog scales (VAS global/pain), EuroQol-5 dimensions and Short-Form 36 physical and mental component summary (SF-36 PCS/MCS) using Spearman correlations, univariate/multivariable linear regression analyses and generalized estimating equations. Furthermore, MRI pathologies were assessed for association with specific hand-related HAQ items using Jonckheere trend tests. Results: Magnetic resonance imaging-assessed damage was associated with impaired HAQ and SF-36 PCS at remission and relapse (P <.01), independent of clinical and radiographic measures, and was also associated with most of the hand-related HAQ items (P <.03). In multivariate models including MRI, SvH scores were not associated with PROs. MRI-assessed inflammation was not associated with PROs at remission or relapse. Conclusion: Magnetic resonance imaging-assessed wrist/hand damage, but not inflammation, in patients with established RA is associated with patient-reported physical impairment at remission and relapse. The amount of damage in the wrist/hand is associated with reduced hand function.
AB - Objective: To investigate whether magnetic resonance imaging (MRI) pathologies in the wrist/hand of rheumatoid arthritis (RA) patients are associated with patient-reported outcomes (PROs) at clinical remission and relapse. Methods: Wrist/hand MRIs and wrists/hands/feet radiographs were obtained in 114 established RA patients in clinical remission, before tapering their biologic disease-modifying antirheumatic drugs. MRIs were assessed according to the Outcome Measures in Rheumatology (OMERACT) RA MRI score (RAMRIS) for inflammation (synovitis/tenosynovitis/bone marrow edema) and damage (bone erosion/joint space narrowing) at baseline (ie remission) and in case of a relapse (n = 70). Radiographs were assessed according to the Sharp/van der Heijde (SvH) method at baseline. These scores were assessed for associations with health assessment questionnaires (HAQ), visual analog scales (VAS global/pain), EuroQol-5 dimensions and Short-Form 36 physical and mental component summary (SF-36 PCS/MCS) using Spearman correlations, univariate/multivariable linear regression analyses and generalized estimating equations. Furthermore, MRI pathologies were assessed for association with specific hand-related HAQ items using Jonckheere trend tests. Results: Magnetic resonance imaging-assessed damage was associated with impaired HAQ and SF-36 PCS at remission and relapse (P <.01), independent of clinical and radiographic measures, and was also associated with most of the hand-related HAQ items (P <.03). In multivariate models including MRI, SvH scores were not associated with PROs. MRI-assessed inflammation was not associated with PROs at remission or relapse. Conclusion: Magnetic resonance imaging-assessed wrist/hand damage, but not inflammation, in patients with established RA is associated with patient-reported physical impairment at remission and relapse. The amount of damage in the wrist/hand is associated with reduced hand function.
KW - hand
KW - magnetic resonance imaging
KW - rheumatoid arthritis
U2 - 10.1111/1756-185X.13790
DO - 10.1111/1756-185X.13790
M3 - Journal article
C2 - 31994328
AN - SCOPUS:85078677308
VL - 23
SP - 488
EP - 498
JO - International Journal of Rheumatic Diseases
JF - International Journal of Rheumatic Diseases
SN - 1756-1841
IS - 4
ER -
ID: 237796112