Differences in Occurrence, Risk Factors and Severity of Early-onset Atopic Dermatitis among Preterm and Term Children
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Differences in Occurrence, Risk Factors and Severity of Early-onset Atopic Dermatitis among Preterm and Term Children. / Gerner, Trine; Rinnov, Maria Rasmussen; Halling, Anne-Sofie; Ravn, Nina Haarup; Knudgaard, Mette Hjorslev; Ewertsen, Caroline; Trautner, Simon; Jakasa, Ivone; Kezic, Sanja; Skov, Lone; Thyssen, Jacob P.
I: Acta Dermato-Venereologica, Bind 102, adv00737, 2022.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Differences in Occurrence, Risk Factors and Severity of Early-onset Atopic Dermatitis among Preterm and Term Children
AU - Gerner, Trine
AU - Rinnov, Maria Rasmussen
AU - Halling, Anne-Sofie
AU - Ravn, Nina Haarup
AU - Knudgaard, Mette Hjorslev
AU - Ewertsen, Caroline
AU - Trautner, Simon
AU - Jakasa, Ivone
AU - Kezic, Sanja
AU - Skov, Lone
AU - Thyssen, Jacob P.
N1 - Publisher Copyright: © 2022, Medical Journals/Acta D-V. All rights reserved.
PY - 2022
Y1 - 2022
N2 - This prospective birth cohort followed 150 preterm and 300 term newborns during the first year of life to assess possible differences in risk factors, age at onset, anatomical location, and severity of atopic der-matitis. Atopic dermatitis was diagnosed clinically, and severity was assessed using Eczema Area Severity Index (EASI). DNA was analysed for filaggrin gene mutations. Parents were asked about environmental exposures and emollient use. Atopic dermatitis during the first year of life was observed in 21.2% of children and was more common in term children compared with preterm children (26.7% vs 11.7%, p < 0.001), with lower age of onset (4 vs 6 months, p < 0.05) and more severe disease at onset (EASI: 4.8 vs 0.4, p < 0.0005). Environmental risk factors for atopic dermatitis were essentially similar for preterm and term born children, apart from winter and autumn births. Filaggrin gene mutations were less common in preterm than term children (4.1% vs 9.2%, p = 0.06).
AB - This prospective birth cohort followed 150 preterm and 300 term newborns during the first year of life to assess possible differences in risk factors, age at onset, anatomical location, and severity of atopic der-matitis. Atopic dermatitis was diagnosed clinically, and severity was assessed using Eczema Area Severity Index (EASI). DNA was analysed for filaggrin gene mutations. Parents were asked about environmental exposures and emollient use. Atopic dermatitis during the first year of life was observed in 21.2% of children and was more common in term children compared with preterm children (26.7% vs 11.7%, p < 0.001), with lower age of onset (4 vs 6 months, p < 0.05) and more severe disease at onset (EASI: 4.8 vs 0.4, p < 0.0005). Environmental risk factors for atopic dermatitis were essentially similar for preterm and term born children, apart from winter and autumn births. Filaggrin gene mutations were less common in preterm than term children (4.1% vs 9.2%, p = 0.06).
KW - atopic dermatitis
KW - cohort study
KW - premature birth
KW - risk factors
U2 - 10.2340/actadv.v102.575
DO - 10.2340/actadv.v102.575
M3 - Journal article
C2 - 35470403
AN - SCOPUS:85132452786
VL - 102
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
SN - 0001-5555
M1 - adv00737
ER -
ID: 325378812