A Comprehensive Pathophysiology of Dandruff and Seborrheic Dermatitis - Towards a More Precise Definition of Scalp Health

Research output: Contribution to journalJournal articleResearchpeer-review

  • James R Schwartz
  • Andrew G Messenger
  • Antonella Tosti
  • Gail Todd
  • Maria Hordinsky
  • Roderick J Hay
  • Xuemin Wang
  • Zachariae, Claus
  • Kathy M Kerr
  • James P Henry
  • Rene C Rust
  • Michael K Robinson
Despite an increasing knowledge of dandruff and seborrheic dermatitis (D/SD), the pathophysiological understanding is still incomplete but suggests a role of Malassezia yeasts in triggering inflammatory and hyper-proliferative epidermal responses. The objective of this report is to review published literature from in vivo studies of D/SD populations to provide a more complete description of overall scalp health. New biomolecular capabilities establish a depth of pathophysiological understanding not previously achievable with traditional means of investigation. Biomarkers representing inflammation, hyper-proliferation and barrier function are all perturbed by the D/SD condition and robustly respond to therapeutic resolution. These biomarkers can be sampled noninvasively, enabling their use in routine clinical evaluations as either surrogate endpoints or complementary ones to classical signs/symptoms to broaden the etiological learning.
Original languageEnglish
JournalActa Dermatovenereologica
Publication statusPublished - 6 Aug 2012

ID: 48613841