Association between atopic dermatitis and contact sensitization: A systematic review and meta-analysis

Research output: Contribution to journalReviewResearchpeer-review

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Association between atopic dermatitis and contact sensitization : A systematic review and meta-analysis. / Hamann, Carsten R; Hamann, Dathan; Egeberg, Alexander; Johansen, Jeanne D; Silverberg, Jonathan; Thyssen, Jacob P.

In: Journal of the American Academy of Dermatology, Vol. 77, No. 1, 2017, p. 70-78.

Research output: Contribution to journalReviewResearchpeer-review

Harvard

Hamann, CR, Hamann, D, Egeberg, A, Johansen, JD, Silverberg, J & Thyssen, JP 2017, 'Association between atopic dermatitis and contact sensitization: A systematic review and meta-analysis', Journal of the American Academy of Dermatology, vol. 77, no. 1, pp. 70-78. https://doi.org/10.1016/j.jaad.2017.02.001

APA

Hamann, C. R., Hamann, D., Egeberg, A., Johansen, J. D., Silverberg, J., & Thyssen, J. P. (2017). Association between atopic dermatitis and contact sensitization: A systematic review and meta-analysis. Journal of the American Academy of Dermatology, 77(1), 70-78. https://doi.org/10.1016/j.jaad.2017.02.001

Vancouver

Hamann CR, Hamann D, Egeberg A, Johansen JD, Silverberg J, Thyssen JP. Association between atopic dermatitis and contact sensitization: A systematic review and meta-analysis. Journal of the American Academy of Dermatology. 2017;77(1):70-78. https://doi.org/10.1016/j.jaad.2017.02.001

Author

Hamann, Carsten R ; Hamann, Dathan ; Egeberg, Alexander ; Johansen, Jeanne D ; Silverberg, Jonathan ; Thyssen, Jacob P. / Association between atopic dermatitis and contact sensitization : A systematic review and meta-analysis. In: Journal of the American Academy of Dermatology. 2017 ; Vol. 77, No. 1. pp. 70-78.

Bibtex

@article{b118621a2039490f8727c550b2da7d6a,
title = "Association between atopic dermatitis and contact sensitization: A systematic review and meta-analysis",
abstract = "BACKGROUND: It is unclear whether patients with atopic dermatitis (AD) have an altered prevalence or risk for contact sensitization. Increased exposure to chemicals in topical products together with impaired skin barrier function suggest a higher risk, whereas the immune profile suggests a lower risk.OBJECTIVE: To perform a systematic review and meta-analysis of the association between AD and contact sensitization.METHODS: The PubMed/Medline, Embase, and Cochrane databases were searched for articles that reported on contact sensitization in individuals with and without AD.RESULTS: The literature search yielded 10,083 citations; 417 were selected based on title and abstract screening and 74 met inclusion criteria. In a pooled analysis, no significant difference in contact sensitization between AD and controls was evident (random effects model odds ratio [OR] = 0.891; 95{\%} confidence interval [CI] = 0.771-1.03). There was a positive correlation in studies that compared AD patients with individuals from the general population (OR 1.50, 95{\%} CI 1.23-1.93) but an inverse association when comparing with referred populations (OR 0.753, 95{\%} CI 0.63-0.90).LIMITATIONS: Included studies used different tools to diagnose AD and did not always provide information on current or past disease. Patch test allergens varied between studies.CONCLUSION: No overall relationship between AD and contact sensitization was found. We recommend that clinicians consider patch testing AD patients when allergic contact dermatitis is suspected.",
keywords = "Dermatitis, Atopic/immunology, Dermatitis, Contact/immunology, Humans",
author = "Hamann, {Carsten R} and Dathan Hamann and Alexander Egeberg and Johansen, {Jeanne D} and Jonathan Silverberg and Thyssen, {Jacob P}",
note = "Copyright {\circledC} 2017 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.",
year = "2017",
doi = "10.1016/j.jaad.2017.02.001",
language = "English",
volume = "77",
pages = "70--78",
journal = "American Academy of Dermatology. Journal",
issn = "0190-9622",
publisher = "Mosby Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Association between atopic dermatitis and contact sensitization

T2 - A systematic review and meta-analysis

AU - Hamann, Carsten R

AU - Hamann, Dathan

AU - Egeberg, Alexander

AU - Johansen, Jeanne D

AU - Silverberg, Jonathan

AU - Thyssen, Jacob P

N1 - Copyright © 2017 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

PY - 2017

Y1 - 2017

N2 - BACKGROUND: It is unclear whether patients with atopic dermatitis (AD) have an altered prevalence or risk for contact sensitization. Increased exposure to chemicals in topical products together with impaired skin barrier function suggest a higher risk, whereas the immune profile suggests a lower risk.OBJECTIVE: To perform a systematic review and meta-analysis of the association between AD and contact sensitization.METHODS: The PubMed/Medline, Embase, and Cochrane databases were searched for articles that reported on contact sensitization in individuals with and without AD.RESULTS: The literature search yielded 10,083 citations; 417 were selected based on title and abstract screening and 74 met inclusion criteria. In a pooled analysis, no significant difference in contact sensitization between AD and controls was evident (random effects model odds ratio [OR] = 0.891; 95% confidence interval [CI] = 0.771-1.03). There was a positive correlation in studies that compared AD patients with individuals from the general population (OR 1.50, 95% CI 1.23-1.93) but an inverse association when comparing with referred populations (OR 0.753, 95% CI 0.63-0.90).LIMITATIONS: Included studies used different tools to diagnose AD and did not always provide information on current or past disease. Patch test allergens varied between studies.CONCLUSION: No overall relationship between AD and contact sensitization was found. We recommend that clinicians consider patch testing AD patients when allergic contact dermatitis is suspected.

AB - BACKGROUND: It is unclear whether patients with atopic dermatitis (AD) have an altered prevalence or risk for contact sensitization. Increased exposure to chemicals in topical products together with impaired skin barrier function suggest a higher risk, whereas the immune profile suggests a lower risk.OBJECTIVE: To perform a systematic review and meta-analysis of the association between AD and contact sensitization.METHODS: The PubMed/Medline, Embase, and Cochrane databases were searched for articles that reported on contact sensitization in individuals with and without AD.RESULTS: The literature search yielded 10,083 citations; 417 were selected based on title and abstract screening and 74 met inclusion criteria. In a pooled analysis, no significant difference in contact sensitization between AD and controls was evident (random effects model odds ratio [OR] = 0.891; 95% confidence interval [CI] = 0.771-1.03). There was a positive correlation in studies that compared AD patients with individuals from the general population (OR 1.50, 95% CI 1.23-1.93) but an inverse association when comparing with referred populations (OR 0.753, 95% CI 0.63-0.90).LIMITATIONS: Included studies used different tools to diagnose AD and did not always provide information on current or past disease. Patch test allergens varied between studies.CONCLUSION: No overall relationship between AD and contact sensitization was found. We recommend that clinicians consider patch testing AD patients when allergic contact dermatitis is suspected.

KW - Dermatitis, Atopic/immunology

KW - Dermatitis, Contact/immunology

KW - Humans

U2 - 10.1016/j.jaad.2017.02.001

DO - 10.1016/j.jaad.2017.02.001

M3 - Review

C2 - 28392290

VL - 77

SP - 70

EP - 78

JO - American Academy of Dermatology. Journal

JF - American Academy of Dermatology. Journal

SN - 0190-9622

IS - 1

ER -

ID: 197369980