Calcitonin gene-related peptide and pain: a systematic review

Research output: Contribution to journalReviewResearchpeer-review


  • Wendy Sophie Schou
  • Sait Ashina
  • Faisal Mohammad Amin
  • Peter J Goadsby
  • dlt446, dlt446

BACKGROUND: Calcitonin gene-related peptide (CGRP) is widely distributed in nociceptive pathways in human peripheral and central nervous system and its receptors are also expressed in pain pathways. CGRP is involved in migraine pathophysiology but its role in non-headache pain has not been clarified.

METHODS: We performed a systematic literature search on PubMed, Embase and for articles on CGRP and non-headache pain covering human studies including experimental studies and randomized clinical trials.

RESULTS: The literature search identified 375 citations of which 50 contained relevant original data. An association between measured CGRP levels and somatic, visceral, neuropathic and inflammatory pain was found. In 13 out of 20 studies in somatic pain conditions, CGRP levels had a positive correlation with pain. Increased CGRP levels were reported in plasma, synovial and cerebrospinal fluid in subjects with musculoskeletal pain. A randomized clinical trial on monoclonal antibody, which selectively binds to and inhibits the activity of CGRP (galcanezumab) in patients with osteoarthritis knee pain, failed to demonstrate improvement of pain compared with placebo. No studies to date have investigated the efficacy of monoclonal antibodies against CGRP receptor in non-headache pain conditions.

CONCLUSION: The present review revealed the association between measured CGRP levels and somatic, visceral, neuropathic and inflammatory pain. These data suggest that CGRP may act as a neuromodulator in non-headache pain conditions. However, more studies are needed to fully understand the role of CGRP in nociceptive processing and therapy of chronic pain.

Original languageEnglish
Article number34
JournalJournal of Headache and Pain
Number of pages17
Publication statusPublished - 2017

    Research areas

  • Calcitonin Gene-Related Peptide/metabolism, Humans, Pain/metabolism

Number of downloads are based on statistics from Google Scholar and

No data available

ID: 194646720