Copenhagen comorbidity in HIV infection (COCOMO) study: a study protocol for a longitudinal, non-interventional assessment of non-AIDS comorbidity in HIV infection in Denmark

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Copenhagen comorbidity in HIV infection (COCOMO) study : a study protocol for a longitudinal, non-interventional assessment of non-AIDS comorbidity in HIV infection in Denmark. / Ronit, Andreas; Haissman, Judith Melchior; Kirkegaard-Klitbo, Ditte Marie; Kristensen, Thomas Skårup; Lebech, Anne-Mette; Benfield, Thomas; Gerstoft, Jan; Ullum, Henrik; Køber, Lars; Kjær, Andreas; Kofoed, Klaus; Vestbo, Jørgen; Nordestgaard, Børge Grønne; Lundgren, Jens; Nielsen, Susanne Dam.

In: BMC Infectious Diseases, Vol. 16, 713, 26.11.2016.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Ronit, A, Haissman, JM, Kirkegaard-Klitbo, DM, Kristensen, TS, Lebech, A-M, Benfield, T, Gerstoft, J, Ullum, H, Køber, L, Kjær, A, Kofoed, K, Vestbo, J, Nordestgaard, BG, Lundgren, J & Nielsen, SD 2016, 'Copenhagen comorbidity in HIV infection (COCOMO) study: a study protocol for a longitudinal, non-interventional assessment of non-AIDS comorbidity in HIV infection in Denmark', BMC Infectious Diseases, vol. 16, 713. https://doi.org/10.1186/s12879-016-2026-9

APA

Ronit, A., Haissman, J. M., Kirkegaard-Klitbo, D. M., Kristensen, T. S., Lebech, A-M., Benfield, T., ... Nielsen, S. D. (2016). Copenhagen comorbidity in HIV infection (COCOMO) study: a study protocol for a longitudinal, non-interventional assessment of non-AIDS comorbidity in HIV infection in Denmark. BMC Infectious Diseases, 16, [713]. https://doi.org/10.1186/s12879-016-2026-9

Vancouver

Ronit A, Haissman JM, Kirkegaard-Klitbo DM, Kristensen TS, Lebech A-M, Benfield T et al. Copenhagen comorbidity in HIV infection (COCOMO) study: a study protocol for a longitudinal, non-interventional assessment of non-AIDS comorbidity in HIV infection in Denmark. BMC Infectious Diseases. 2016 Nov 26;16. 713. https://doi.org/10.1186/s12879-016-2026-9

Author

Ronit, Andreas ; Haissman, Judith Melchior ; Kirkegaard-Klitbo, Ditte Marie ; Kristensen, Thomas Skårup ; Lebech, Anne-Mette ; Benfield, Thomas ; Gerstoft, Jan ; Ullum, Henrik ; Køber, Lars ; Kjær, Andreas ; Kofoed, Klaus ; Vestbo, Jørgen ; Nordestgaard, Børge Grønne ; Lundgren, Jens ; Nielsen, Susanne Dam. / Copenhagen comorbidity in HIV infection (COCOMO) study : a study protocol for a longitudinal, non-interventional assessment of non-AIDS comorbidity in HIV infection in Denmark. In: BMC Infectious Diseases. 2016 ; Vol. 16.

Bibtex

@article{da35823da6694b8093702a8fcc20f359,
title = "Copenhagen comorbidity in HIV infection (COCOMO) study: a study protocol for a longitudinal, non-interventional assessment of non-AIDS comorbidity in HIV infection in Denmark",
abstract = "BACKGROUND: Modern combination antiretroviral therapy (cART) has improved survival for people living with HIV (PLWHIV). Non-AIDS comorbidities have replaced opportunistic infections as leading causes of mortality and morbidity, and are becoming a key health concern as this population continues to age. The aim of this study is to estimate the prevalence and incidence of non-AIDS comorbidity among PLWHIV in Denmark in the cART era and to determine risk factors contributing to the pathogenesis. The study primarily targets cardiovascular, respiratory, and hepatic non-AIDS comorbidity.METHODS/DESIGN: The Copenhagen comorbidity in HIV-infection (COCOMO) study is an observational, longitudinal cohort study. The study was initiated in 2015 and recruitment is ongoing with the aim of including 1500 PLWHIV from the Copenhagen area. Follow-up examinations after 2 and 10 years are planned. Uninfected controls are derived from the Copenhagen General Population Study (CGPS), a cohort study including 100,000 uninfected participants from the same geographical region. Physiological and biological measures including blood pressure, ankle-brachial index, electrocardiogram, spirometry, exhaled nitric oxide, transient elastography of the liver, computed tomography (CT) angiography of the heart, unenhanced CT of the chest and upper abdomen, and a number of routine biochemical analysis are uniformly collected in participants from the COCOMO study and the CGPS. Plasma, serum, buffy coat, peripheral blood mononuclear cells (PBMC), urine, and stool samples are collected in a biobank for future studies. Data will be updated through periodical linking to national databases.DISCUSSION: As life expectancy for PLWHIV improves, it is essential to study long-term impact of HIV and cART. We anticipate that findings from this cohort study will increase knowledge on non-AIDS comorbidity in PLWHIV and identify targets for future interventional trials. Recognizing the demographic, clinical and pathophysiological characteristics of comorbidity in PLWHIV may help inform development of new guidelines and enable us to move forward to a more personalized HIV care.TRIAL REGISTRATION: ClinicalTrials.gov: NCT02382822 .",
author = "Andreas Ronit and Haissman, {Judith Melchior} and Kirkegaard-Klitbo, {Ditte Marie} and Kristensen, {Thomas Sk{\aa}rup} and Anne-Mette Lebech and Thomas Benfield and Jan Gerstoft and Henrik Ullum and Lars K{\o}ber and Andreas Kj{\ae}r and Klaus Kofoed and J{\o}rgen Vestbo and Nordestgaard, {B{\o}rge Gr{\o}nne} and Jens Lundgren and Nielsen, {Susanne Dam}",
year = "2016",
month = "11",
day = "26",
doi = "10.1186/s12879-016-2026-9",
language = "English",
volume = "16",
journal = "B M C Infectious Diseases",
issn = "1471-2334",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Copenhagen comorbidity in HIV infection (COCOMO) study

T2 - a study protocol for a longitudinal, non-interventional assessment of non-AIDS comorbidity in HIV infection in Denmark

AU - Ronit, Andreas

AU - Haissman, Judith Melchior

AU - Kirkegaard-Klitbo, Ditte Marie

AU - Kristensen, Thomas Skårup

AU - Lebech, Anne-Mette

AU - Benfield, Thomas

AU - Gerstoft, Jan

AU - Ullum, Henrik

AU - Køber, Lars

AU - Kjær, Andreas

AU - Kofoed, Klaus

AU - Vestbo, Jørgen

AU - Nordestgaard, Børge Grønne

AU - Lundgren, Jens

AU - Nielsen, Susanne Dam

PY - 2016/11/26

Y1 - 2016/11/26

N2 - BACKGROUND: Modern combination antiretroviral therapy (cART) has improved survival for people living with HIV (PLWHIV). Non-AIDS comorbidities have replaced opportunistic infections as leading causes of mortality and morbidity, and are becoming a key health concern as this population continues to age. The aim of this study is to estimate the prevalence and incidence of non-AIDS comorbidity among PLWHIV in Denmark in the cART era and to determine risk factors contributing to the pathogenesis. The study primarily targets cardiovascular, respiratory, and hepatic non-AIDS comorbidity.METHODS/DESIGN: The Copenhagen comorbidity in HIV-infection (COCOMO) study is an observational, longitudinal cohort study. The study was initiated in 2015 and recruitment is ongoing with the aim of including 1500 PLWHIV from the Copenhagen area. Follow-up examinations after 2 and 10 years are planned. Uninfected controls are derived from the Copenhagen General Population Study (CGPS), a cohort study including 100,000 uninfected participants from the same geographical region. Physiological and biological measures including blood pressure, ankle-brachial index, electrocardiogram, spirometry, exhaled nitric oxide, transient elastography of the liver, computed tomography (CT) angiography of the heart, unenhanced CT of the chest and upper abdomen, and a number of routine biochemical analysis are uniformly collected in participants from the COCOMO study and the CGPS. Plasma, serum, buffy coat, peripheral blood mononuclear cells (PBMC), urine, and stool samples are collected in a biobank for future studies. Data will be updated through periodical linking to national databases.DISCUSSION: As life expectancy for PLWHIV improves, it is essential to study long-term impact of HIV and cART. We anticipate that findings from this cohort study will increase knowledge on non-AIDS comorbidity in PLWHIV and identify targets for future interventional trials. Recognizing the demographic, clinical and pathophysiological characteristics of comorbidity in PLWHIV may help inform development of new guidelines and enable us to move forward to a more personalized HIV care.TRIAL REGISTRATION: ClinicalTrials.gov: NCT02382822 .

AB - BACKGROUND: Modern combination antiretroviral therapy (cART) has improved survival for people living with HIV (PLWHIV). Non-AIDS comorbidities have replaced opportunistic infections as leading causes of mortality and morbidity, and are becoming a key health concern as this population continues to age. The aim of this study is to estimate the prevalence and incidence of non-AIDS comorbidity among PLWHIV in Denmark in the cART era and to determine risk factors contributing to the pathogenesis. The study primarily targets cardiovascular, respiratory, and hepatic non-AIDS comorbidity.METHODS/DESIGN: The Copenhagen comorbidity in HIV-infection (COCOMO) study is an observational, longitudinal cohort study. The study was initiated in 2015 and recruitment is ongoing with the aim of including 1500 PLWHIV from the Copenhagen area. Follow-up examinations after 2 and 10 years are planned. Uninfected controls are derived from the Copenhagen General Population Study (CGPS), a cohort study including 100,000 uninfected participants from the same geographical region. Physiological and biological measures including blood pressure, ankle-brachial index, electrocardiogram, spirometry, exhaled nitric oxide, transient elastography of the liver, computed tomography (CT) angiography of the heart, unenhanced CT of the chest and upper abdomen, and a number of routine biochemical analysis are uniformly collected in participants from the COCOMO study and the CGPS. Plasma, serum, buffy coat, peripheral blood mononuclear cells (PBMC), urine, and stool samples are collected in a biobank for future studies. Data will be updated through periodical linking to national databases.DISCUSSION: As life expectancy for PLWHIV improves, it is essential to study long-term impact of HIV and cART. We anticipate that findings from this cohort study will increase knowledge on non-AIDS comorbidity in PLWHIV and identify targets for future interventional trials. Recognizing the demographic, clinical and pathophysiological characteristics of comorbidity in PLWHIV may help inform development of new guidelines and enable us to move forward to a more personalized HIV care.TRIAL REGISTRATION: ClinicalTrials.gov: NCT02382822 .

U2 - 10.1186/s12879-016-2026-9

DO - 10.1186/s12879-016-2026-9

M3 - Journal article

C2 - 27887644

VL - 16

JO - B M C Infectious Diseases

JF - B M C Infectious Diseases

SN - 1471-2334

M1 - 713

ER -

ID: 173125375