Experimental patch testing with chromium-coated materials
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Experimental patch testing with chromium-coated materials. / Bregnbak, David; Thyssen, Jacob P.; Jellesen, Morten S.; Zachariae, Claus; Johansen, Jeanne D.
In: Contact Dermatitis, Vol. 76, No. 6, 2017, p. 333-341.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Experimental patch testing with chromium-coated materials
AU - Bregnbak, David
AU - Thyssen, Jacob P.
AU - Jellesen, Morten S.
AU - Zachariae, Claus
AU - Johansen, Jeanne D.
PY - 2017
Y1 - 2017
N2 - Background: Chromium coatings on metal alloys can be decorative, and prevent corrosion and metal ion release. We recently showed that handling of a chromium-containing disc resulted in chromium deposition on the skin. Objectives: To examine patch test reactivity to chromium-coated discs. Methods: We included 15 patients: 10 chromium-allergic patients, and 5 patients without chromium allergy. All were patch tested with potassium dichromate, cobalt chloride, nickel sulfate, and nine different metallic discs. The chromium-allergic patients were also patch tested with serial dilutions of potassium dichromate. Results: Positive/weaker reactions were observed to disc B (1 of 10), disc C (1 of 10), and disc D, disc E, and disc I (4 of 10 each). As no controls reacted to any of the discs, the weak reactions indicate allergic reactions. Positive patch test reactions to 1770 ppm chromium(VI) in the serial dilutions of potassium dichromate were observed in 7 of 10 patients. When the case group was narrowed down to include only the patients with a current positive patch test reaction to potassium dichromate, elicitation of dermatitis by both chromium(III) and chromium(VI) discs was observed in 4 of 7 of patients. Conclusions: Many of the patients reacted to both chromium(III) and chromium(VI) surfaces. Our results indicate that both chromium(VI) and chromium(III) pose a risk to chromium-allergic patients.
AB - Background: Chromium coatings on metal alloys can be decorative, and prevent corrosion and metal ion release. We recently showed that handling of a chromium-containing disc resulted in chromium deposition on the skin. Objectives: To examine patch test reactivity to chromium-coated discs. Methods: We included 15 patients: 10 chromium-allergic patients, and 5 patients without chromium allergy. All were patch tested with potassium dichromate, cobalt chloride, nickel sulfate, and nine different metallic discs. The chromium-allergic patients were also patch tested with serial dilutions of potassium dichromate. Results: Positive/weaker reactions were observed to disc B (1 of 10), disc C (1 of 10), and disc D, disc E, and disc I (4 of 10 each). As no controls reacted to any of the discs, the weak reactions indicate allergic reactions. Positive patch test reactions to 1770 ppm chromium(VI) in the serial dilutions of potassium dichromate were observed in 7 of 10 patients. When the case group was narrowed down to include only the patients with a current positive patch test reaction to potassium dichromate, elicitation of dermatitis by both chromium(III) and chromium(VI) discs was observed in 4 of 7 of patients. Conclusions: Many of the patients reacted to both chromium(III) and chromium(VI) surfaces. Our results indicate that both chromium(VI) and chromium(III) pose a risk to chromium-allergic patients.
KW - allergic chromium dermatitis
KW - allergy
KW - chromium
KW - dermatitis
KW - leather
KW - metals
KW - potassium dichromate
U2 - 10.1111/cod.12747
DO - 10.1111/cod.12747
M3 - Journal article
C2 - 28120332
AN - SCOPUS:85017347431
VL - 76
SP - 333
EP - 341
JO - Contact Dermatitis
JF - Contact Dermatitis
SN - 0105-1873
IS - 6
ER -
ID: 196142149