Health-related quality of life in adult dermatitis patients stratified by filaggrin genotype

Research output: Contribution to journalJournal articleResearchpeer-review

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Health-related quality of life in adult dermatitis patients stratified by filaggrin genotype. / Heede, Nina G; Thyssen, Jacob P; Thuesen, Betina H; Linneberg, Allan; Szecsi, Pal B; Stender, Steen; Johansen, Jeanne D.

In: Contact Dermatitis, Vol. 76, No. 3, 03.2017, p. 167-177.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Heede, NG, Thyssen, JP, Thuesen, BH, Linneberg, A, Szecsi, PB, Stender, S & Johansen, JD 2017, 'Health-related quality of life in adult dermatitis patients stratified by filaggrin genotype', Contact Dermatitis, vol. 76, no. 3, pp. 167-177. https://doi.org/10.1111/cod.12731

APA

Heede, N. G., Thyssen, J. P., Thuesen, B. H., Linneberg, A., Szecsi, P. B., Stender, S., & Johansen, J. D. (2017). Health-related quality of life in adult dermatitis patients stratified by filaggrin genotype. Contact Dermatitis, 76(3), 167-177. https://doi.org/10.1111/cod.12731

Vancouver

Heede NG, Thyssen JP, Thuesen BH, Linneberg A, Szecsi PB, Stender S et al. Health-related quality of life in adult dermatitis patients stratified by filaggrin genotype. Contact Dermatitis. 2017 Mar;76(3):167-177. https://doi.org/10.1111/cod.12731

Author

Heede, Nina G ; Thyssen, Jacob P ; Thuesen, Betina H ; Linneberg, Allan ; Szecsi, Pal B ; Stender, Steen ; Johansen, Jeanne D. / Health-related quality of life in adult dermatitis patients stratified by filaggrin genotype. In: Contact Dermatitis. 2017 ; Vol. 76, No. 3. pp. 167-177.

Bibtex

@article{d39ce430c4674896bfe055bf8b50588d,
title = "Health-related quality of life in adult dermatitis patients stratified by filaggrin genotype",
abstract = "BACKGROUND: Information concerning health-related quality of life (HRQoL) and comorbidities of adult dermatitis patients stratified by loss-of-function mutations in the filaggrin gene (FLG) is limited.OBJECTIVE: To investigate HRQoL, skin symptoms and comorbidities in adult FLG mutation carriers.METHODS: This cross-sectional study included patients diagnosed with atopic dermatitis and/or hand eczema (n = 520). Patients completed questionnaires about dermatitis, skin symptoms, HRQoL, and comorbidities, including actinic keratosis, and atopic and mental disorders.RESULTS: FLG mutations (R501X, 2282del4, and R2447X) were identified in 16.9{\%} of patients, and were significantly associated not only with atopic dermatitis, but also independently with skin fissures on the fingers and heels, and self-reported actinic keratosis. Although FLG mutations were significantly associated with reduced HRQoL, as measured by use of the Dermatology Life Quality Index (DLQI), no association with self-reported anxiety or depression was identified. Notably, the highest median DLQI score, reflecting greater impairment, was reported by patients with both FLG mutations and atopic dermatitis. Overall, 19.7{\%} of patients with both atopic dermatitis and FLG mutations reported a 'large or extremely large' impact on their lives; this represents twice the prevalence seen in patients with atopic dermatitis and wild-type FLG (9.6{\%}).CONCLUSION: Patients with both atopic dermatitis and common FLG mutations are more frequently affected by reduced HRQoL.",
author = "Heede, {Nina G} and Thyssen, {Jacob P} and Thuesen, {Betina H} and Allan Linneberg and Szecsi, {Pal B} and Steen Stender and Johansen, {Jeanne D}",
note = "{\circledC} 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",
year = "2017",
month = "3",
doi = "10.1111/cod.12731",
language = "English",
volume = "76",
pages = "167--177",
journal = "Contact Dermatitis",
issn = "0105-1873",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Health-related quality of life in adult dermatitis patients stratified by filaggrin genotype

AU - Heede, Nina G

AU - Thyssen, Jacob P

AU - Thuesen, Betina H

AU - Linneberg, Allan

AU - Szecsi, Pal B

AU - Stender, Steen

AU - Johansen, Jeanne D

N1 - © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2017/3

Y1 - 2017/3

N2 - BACKGROUND: Information concerning health-related quality of life (HRQoL) and comorbidities of adult dermatitis patients stratified by loss-of-function mutations in the filaggrin gene (FLG) is limited.OBJECTIVE: To investigate HRQoL, skin symptoms and comorbidities in adult FLG mutation carriers.METHODS: This cross-sectional study included patients diagnosed with atopic dermatitis and/or hand eczema (n = 520). Patients completed questionnaires about dermatitis, skin symptoms, HRQoL, and comorbidities, including actinic keratosis, and atopic and mental disorders.RESULTS: FLG mutations (R501X, 2282del4, and R2447X) were identified in 16.9% of patients, and were significantly associated not only with atopic dermatitis, but also independently with skin fissures on the fingers and heels, and self-reported actinic keratosis. Although FLG mutations were significantly associated with reduced HRQoL, as measured by use of the Dermatology Life Quality Index (DLQI), no association with self-reported anxiety or depression was identified. Notably, the highest median DLQI score, reflecting greater impairment, was reported by patients with both FLG mutations and atopic dermatitis. Overall, 19.7% of patients with both atopic dermatitis and FLG mutations reported a 'large or extremely large' impact on their lives; this represents twice the prevalence seen in patients with atopic dermatitis and wild-type FLG (9.6%).CONCLUSION: Patients with both atopic dermatitis and common FLG mutations are more frequently affected by reduced HRQoL.

AB - BACKGROUND: Information concerning health-related quality of life (HRQoL) and comorbidities of adult dermatitis patients stratified by loss-of-function mutations in the filaggrin gene (FLG) is limited.OBJECTIVE: To investigate HRQoL, skin symptoms and comorbidities in adult FLG mutation carriers.METHODS: This cross-sectional study included patients diagnosed with atopic dermatitis and/or hand eczema (n = 520). Patients completed questionnaires about dermatitis, skin symptoms, HRQoL, and comorbidities, including actinic keratosis, and atopic and mental disorders.RESULTS: FLG mutations (R501X, 2282del4, and R2447X) were identified in 16.9% of patients, and were significantly associated not only with atopic dermatitis, but also independently with skin fissures on the fingers and heels, and self-reported actinic keratosis. Although FLG mutations were significantly associated with reduced HRQoL, as measured by use of the Dermatology Life Quality Index (DLQI), no association with self-reported anxiety or depression was identified. Notably, the highest median DLQI score, reflecting greater impairment, was reported by patients with both FLG mutations and atopic dermatitis. Overall, 19.7% of patients with both atopic dermatitis and FLG mutations reported a 'large or extremely large' impact on their lives; this represents twice the prevalence seen in patients with atopic dermatitis and wild-type FLG (9.6%).CONCLUSION: Patients with both atopic dermatitis and common FLG mutations are more frequently affected by reduced HRQoL.

U2 - 10.1111/cod.12731

DO - 10.1111/cod.12731

M3 - Journal article

C2 - 27995642

VL - 76

SP - 167

EP - 177

JO - Contact Dermatitis

JF - Contact Dermatitis

SN - 0105-1873

IS - 3

ER -

ID: 173160284