Increase in vitamin d but not regulatory t cells following ultraviolet b phototherapy of patients with atopic dermatitis

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This study investigated serum 25-hydroxyvitamin D (25(OH)D) concentrations and circulating regulatory T cells in patients with atopic dermatitis receiving narrow-band ultraviolet B (nbUVB) phototherapy. Thirty adult patients with atopic dermatitis were included. Blood samples were collected at baseline and at weeks 2 and 4 of nbUVB phototherapy. Skin biopsies were taken at baseline and at week 4. Serum 25(OH) D concentrations increased significantly following nbUVB phototherapy (estimate of change from baseline to week 2: 32.00 nmol/l, confidence interval (CI) 20.48–43.52, p < 0.0001, n = 25; and from baseline to week 4: 50.30 nmol/l, CI 37.28–63.33, p < 0.0001, n = 18). This increase was independent of the filaggrin gene loss-of-function mutation status. Flow cytometry showed no significant change in regulatory T cells or cytokine profiles of T cells in blood. Real-time quantitative PCR showed no change in skin cytokine levels. In conclusion, nbUVB phototherapy was associated with increased serum 25(OH)D concentrations, but not changes in circulating regulatory T cells in patients with atopic dermatitis.

Original languageEnglish
JournalActa Dermato-Venereologica
Volume99
Issue number2
Pages (from-to)139-145
Number of pages7
ISSN0001-5555
DOIs
Publication statusPublished - 2019

    Research areas

  • 25-hydroxyvitamin D, Atopic dermatitis, Filaggrin, NbUVB phototherapy, Regulatory T cells

ID: 216872777