Oral symptoms and salivary findings in oral lichen planus, oral lichenoid lesions and stomatitis

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Oral symptoms and salivary findings in oral lichen planus, oral lichenoid lesions and stomatitis. / Larsen, Kristine Roen; Johansen, Jeanne Duus; Reibel, Jesper; Zachariae, Claus; Rosing, Kasper; Pedersen, Anne Marie Lynge.

In: B M C Oral Health, Vol. 17, 103, 29.06.2017.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Larsen, KR, Johansen, JD, Reibel, J, Zachariae, C, Rosing, K & Pedersen, AML 2017, 'Oral symptoms and salivary findings in oral lichen planus, oral lichenoid lesions and stomatitis', B M C Oral Health, vol. 17, 103. https://doi.org/10.1186/s12903-017-0393-2

APA

Larsen, K. R., Johansen, J. D., Reibel, J., Zachariae, C., Rosing, K., & Pedersen, A. M. L. (2017). Oral symptoms and salivary findings in oral lichen planus, oral lichenoid lesions and stomatitis. B M C Oral Health, 17, [103]. https://doi.org/10.1186/s12903-017-0393-2

Vancouver

Larsen KR, Johansen JD, Reibel J, Zachariae C, Rosing K, Pedersen AML. Oral symptoms and salivary findings in oral lichen planus, oral lichenoid lesions and stomatitis. B M C Oral Health. 2017 Jun 29;17. 103. https://doi.org/10.1186/s12903-017-0393-2

Author

Larsen, Kristine Roen ; Johansen, Jeanne Duus ; Reibel, Jesper ; Zachariae, Claus ; Rosing, Kasper ; Pedersen, Anne Marie Lynge. / Oral symptoms and salivary findings in oral lichen planus, oral lichenoid lesions and stomatitis. In: B M C Oral Health. 2017 ; Vol. 17.

Bibtex

@article{571e05f1ae10438e803a7fa6a95c3209,
title = "Oral symptoms and salivary findings in oral lichen planus, oral lichenoid lesions and stomatitis",
abstract = "BACKGROUND: To examine if patients with oral lichen planus, oral lichenoid lesions and generalised stomatitis and concomitant contact allergy have more frequent and severe xerostomia, lower unstimulated and chewing-stimulated saliva and citric-acid-stimulated parotid saliva flow rates, and higher salivary concentration of total protein and sIgA than cases without contact allergy and healthy controls.METHODS: Forty-nine patients (42 women, aged 61.0 ± 10.3 years) and 29 healthy age- and gender-matched subjects underwent a standardised questionnaire on general and oral health, assessment of xerostomia, clinical examination, sialometry, mucosal biopsy and contact allergy testing.RESULTS: Nineteen patients had oral lichen planus, 19 patients had oral lichenoid lesions and 11 patients had generalised stomatitis. 38.8{\%} had contact allergy. Xerostomia was significantly more common and severe in patients (46.9{\%}) than in healthy controls, whereas the saliva flow rates did not differ. The patients had higher sIgA levels in unstimulated and chewing-stimulated saliva than the healthy controls. The total protein concentration in saliva was lower in the unstimulated saliva samples whereas it was higher in the chewing stimulated saliva samples from patients when compared to healthy controls. The differences were not significant and they were irrespective of the presence of contact allergy.CONCLUSION: Xerostomia is prevalent in patients with oral lichen planus, lichenoid lesions and generalised stomatitis, but not associated with salivary gland hypofunction, numbers of systemic diseases or medications, contact allergy, age, or gender. Salivary sIgA levels were higher in patients than in healthy controls, but did not differ between patient groups. The total salivary protein concentration was lower in unstimulated saliva samples and higher in chewing-stimulated saliva samples in patients than in healthy controls, but did not differ between patient groups. Our findings do not aid in the discrimination between OLP and OLL and these conditions with or without contact allergic reactions.",
keywords = "Journal Article",
author = "Larsen, {Kristine Roen} and Johansen, {Jeanne Duus} and Jesper Reibel and Claus Zachariae and Kasper Rosing and Pedersen, {Anne Marie Lynge}",
year = "2017",
month = "6",
day = "29",
doi = "10.1186/s12903-017-0393-2",
language = "English",
volume = "17",
journal = "B M C Oral Health",
issn = "1472-6831",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Oral symptoms and salivary findings in oral lichen planus, oral lichenoid lesions and stomatitis

AU - Larsen, Kristine Roen

AU - Johansen, Jeanne Duus

AU - Reibel, Jesper

AU - Zachariae, Claus

AU - Rosing, Kasper

AU - Pedersen, Anne Marie Lynge

PY - 2017/6/29

Y1 - 2017/6/29

N2 - BACKGROUND: To examine if patients with oral lichen planus, oral lichenoid lesions and generalised stomatitis and concomitant contact allergy have more frequent and severe xerostomia, lower unstimulated and chewing-stimulated saliva and citric-acid-stimulated parotid saliva flow rates, and higher salivary concentration of total protein and sIgA than cases without contact allergy and healthy controls.METHODS: Forty-nine patients (42 women, aged 61.0 ± 10.3 years) and 29 healthy age- and gender-matched subjects underwent a standardised questionnaire on general and oral health, assessment of xerostomia, clinical examination, sialometry, mucosal biopsy and contact allergy testing.RESULTS: Nineteen patients had oral lichen planus, 19 patients had oral lichenoid lesions and 11 patients had generalised stomatitis. 38.8% had contact allergy. Xerostomia was significantly more common and severe in patients (46.9%) than in healthy controls, whereas the saliva flow rates did not differ. The patients had higher sIgA levels in unstimulated and chewing-stimulated saliva than the healthy controls. The total protein concentration in saliva was lower in the unstimulated saliva samples whereas it was higher in the chewing stimulated saliva samples from patients when compared to healthy controls. The differences were not significant and they were irrespective of the presence of contact allergy.CONCLUSION: Xerostomia is prevalent in patients with oral lichen planus, lichenoid lesions and generalised stomatitis, but not associated with salivary gland hypofunction, numbers of systemic diseases or medications, contact allergy, age, or gender. Salivary sIgA levels were higher in patients than in healthy controls, but did not differ between patient groups. The total salivary protein concentration was lower in unstimulated saliva samples and higher in chewing-stimulated saliva samples in patients than in healthy controls, but did not differ between patient groups. Our findings do not aid in the discrimination between OLP and OLL and these conditions with or without contact allergic reactions.

AB - BACKGROUND: To examine if patients with oral lichen planus, oral lichenoid lesions and generalised stomatitis and concomitant contact allergy have more frequent and severe xerostomia, lower unstimulated and chewing-stimulated saliva and citric-acid-stimulated parotid saliva flow rates, and higher salivary concentration of total protein and sIgA than cases without contact allergy and healthy controls.METHODS: Forty-nine patients (42 women, aged 61.0 ± 10.3 years) and 29 healthy age- and gender-matched subjects underwent a standardised questionnaire on general and oral health, assessment of xerostomia, clinical examination, sialometry, mucosal biopsy and contact allergy testing.RESULTS: Nineteen patients had oral lichen planus, 19 patients had oral lichenoid lesions and 11 patients had generalised stomatitis. 38.8% had contact allergy. Xerostomia was significantly more common and severe in patients (46.9%) than in healthy controls, whereas the saliva flow rates did not differ. The patients had higher sIgA levels in unstimulated and chewing-stimulated saliva than the healthy controls. The total protein concentration in saliva was lower in the unstimulated saliva samples whereas it was higher in the chewing stimulated saliva samples from patients when compared to healthy controls. The differences were not significant and they were irrespective of the presence of contact allergy.CONCLUSION: Xerostomia is prevalent in patients with oral lichen planus, lichenoid lesions and generalised stomatitis, but not associated with salivary gland hypofunction, numbers of systemic diseases or medications, contact allergy, age, or gender. Salivary sIgA levels were higher in patients than in healthy controls, but did not differ between patient groups. The total salivary protein concentration was lower in unstimulated saliva samples and higher in chewing-stimulated saliva samples in patients than in healthy controls, but did not differ between patient groups. Our findings do not aid in the discrimination between OLP and OLL and these conditions with or without contact allergic reactions.

KW - Journal Article

U2 - 10.1186/s12903-017-0393-2

DO - 10.1186/s12903-017-0393-2

M3 - Journal article

C2 - 28662707

VL - 17

JO - B M C Oral Health

JF - B M C Oral Health

SN - 1472-6831

M1 - 103

ER -

ID: 185029674