Perinatal characteristics, older siblings, and risk of ankylosing spondylitis: a case-control study based on national registers

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Perinatal characteristics, older siblings, and risk of ankylosing spondylitis : a case-control study based on national registers. / Lindström, Ulf; Forsblad-d'Elia, Helena; Askling, Johan; Kristensen, Lars Erik; Lie, Elisabeth; Exarchou, Sofia; Jacobsson, Lennart.

In: Arthritis Research & Therapy, Vol. 18, 16, 19.01.2016.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Lindström, U, Forsblad-d'Elia, H, Askling, J, Kristensen, LE, Lie, E, Exarchou, S & Jacobsson, L 2016, 'Perinatal characteristics, older siblings, and risk of ankylosing spondylitis: a case-control study based on national registers', Arthritis Research & Therapy, vol. 18, 16. https://doi.org/10.1186/s13075-016-0917-1

APA

Lindström, U., Forsblad-d'Elia, H., Askling, J., Kristensen, L. E., Lie, E., Exarchou, S., & Jacobsson, L. (2016). Perinatal characteristics, older siblings, and risk of ankylosing spondylitis: a case-control study based on national registers. Arthritis Research & Therapy, 18, [16]. https://doi.org/10.1186/s13075-016-0917-1

Vancouver

Lindström U, Forsblad-d'Elia H, Askling J, Kristensen LE, Lie E, Exarchou S et al. Perinatal characteristics, older siblings, and risk of ankylosing spondylitis: a case-control study based on national registers. Arthritis Research & Therapy. 2016 Jan 19;18. 16. https://doi.org/10.1186/s13075-016-0917-1

Author

Lindström, Ulf ; Forsblad-d'Elia, Helena ; Askling, Johan ; Kristensen, Lars Erik ; Lie, Elisabeth ; Exarchou, Sofia ; Jacobsson, Lennart. / Perinatal characteristics, older siblings, and risk of ankylosing spondylitis : a case-control study based on national registers. In: Arthritis Research & Therapy. 2016 ; Vol. 18.

Bibtex

@article{9899b685046a40ffb7e22ff84649feec,
title = "Perinatal characteristics, older siblings, and risk of ankylosing spondylitis: a case-control study based on national registers",
abstract = "BACKGROUND: The effect of circumstances and exposures early in life on the risk of developing ankylosing spondylitis (AS) is largely unknown. The purpose of this study was to determine whether perinatal characteristics predict development of AS.METHODS: AS cases (n = 1960; 59 {\%} men) were defined as listed with a diagnosis of AS at least once in the Swedish National Patient Register and registered in the Swedish Medical Birth Register (born ≥1973). Population controls were retrieved from the Swedish Population Register (n = 8378; mean 4.3 controls/case), matched on birth year, sex and county. Odds ratios (OR) for developing AS were determined through conditional logistic regression, with regard to: birth weight, birth order, season of birth, maternal age, gestational length, size for gestational age, type of birth, mode of delivery, congenital malformations, mothers' country of birth, mothers' civil status and size of delivery unit.RESULTS: In the univariate analyses statistically significant increases in risk for developing AS were observed for having older siblings (OR 1.18; 95 {\%} Cl 1.06-1.30). No association was observed for the remainder of analysed exposures, although there was a weak association with birth weight below 3000 g (OR 1.19; 95 {\%} CI 1.04-1.37), though not for {"}low birth weight{"} <2500 g (OR 0.90; 95 {\%} CI 0.70-1.16). The increase in risk associated with having older siblings was consistent in a multivariate analysis adjusting for possible confounders (OR 1.23; 95 {\%} Cl 1.09-1.39). The direction and magnitude of the point estimates were also consistent in several sensitivity analyses and when stratifying by sex.CONCLUSIONS: Having older siblings was associated with an increased risk for developing AS. These results need to be repeated and confirmed in other cohorts.",
keywords = "Adult, Birth Weight, Case-Control Studies, Female, Humans, Male, Perinatal Care, Pregnancy, Registries, Risk Factors, Seasons, Siblings, Spondylitis, Ankylosing, Sweden, Young Adult, Journal Article, Research Support, Non-U.S. Gov't",
author = "Ulf Lindstr{\"o}m and Helena Forsblad-d'Elia and Johan Askling and Kristensen, {Lars Erik} and Elisabeth Lie and Sofia Exarchou and Lennart Jacobsson",
year = "2016",
month = "1",
day = "19",
doi = "10.1186/s13075-016-0917-1",
language = "English",
volume = "18",
journal = "Arthritis Research & Therapy",
issn = "1478-6354",
publisher = "BioMed Central",

}

RIS

TY - JOUR

T1 - Perinatal characteristics, older siblings, and risk of ankylosing spondylitis

T2 - a case-control study based on national registers

AU - Lindström, Ulf

AU - Forsblad-d'Elia, Helena

AU - Askling, Johan

AU - Kristensen, Lars Erik

AU - Lie, Elisabeth

AU - Exarchou, Sofia

AU - Jacobsson, Lennart

PY - 2016/1/19

Y1 - 2016/1/19

N2 - BACKGROUND: The effect of circumstances and exposures early in life on the risk of developing ankylosing spondylitis (AS) is largely unknown. The purpose of this study was to determine whether perinatal characteristics predict development of AS.METHODS: AS cases (n = 1960; 59 % men) were defined as listed with a diagnosis of AS at least once in the Swedish National Patient Register and registered in the Swedish Medical Birth Register (born ≥1973). Population controls were retrieved from the Swedish Population Register (n = 8378; mean 4.3 controls/case), matched on birth year, sex and county. Odds ratios (OR) for developing AS were determined through conditional logistic regression, with regard to: birth weight, birth order, season of birth, maternal age, gestational length, size for gestational age, type of birth, mode of delivery, congenital malformations, mothers' country of birth, mothers' civil status and size of delivery unit.RESULTS: In the univariate analyses statistically significant increases in risk for developing AS were observed for having older siblings (OR 1.18; 95 % Cl 1.06-1.30). No association was observed for the remainder of analysed exposures, although there was a weak association with birth weight below 3000 g (OR 1.19; 95 % CI 1.04-1.37), though not for "low birth weight" <2500 g (OR 0.90; 95 % CI 0.70-1.16). The increase in risk associated with having older siblings was consistent in a multivariate analysis adjusting for possible confounders (OR 1.23; 95 % Cl 1.09-1.39). The direction and magnitude of the point estimates were also consistent in several sensitivity analyses and when stratifying by sex.CONCLUSIONS: Having older siblings was associated with an increased risk for developing AS. These results need to be repeated and confirmed in other cohorts.

AB - BACKGROUND: The effect of circumstances and exposures early in life on the risk of developing ankylosing spondylitis (AS) is largely unknown. The purpose of this study was to determine whether perinatal characteristics predict development of AS.METHODS: AS cases (n = 1960; 59 % men) were defined as listed with a diagnosis of AS at least once in the Swedish National Patient Register and registered in the Swedish Medical Birth Register (born ≥1973). Population controls were retrieved from the Swedish Population Register (n = 8378; mean 4.3 controls/case), matched on birth year, sex and county. Odds ratios (OR) for developing AS were determined through conditional logistic regression, with regard to: birth weight, birth order, season of birth, maternal age, gestational length, size for gestational age, type of birth, mode of delivery, congenital malformations, mothers' country of birth, mothers' civil status and size of delivery unit.RESULTS: In the univariate analyses statistically significant increases in risk for developing AS were observed for having older siblings (OR 1.18; 95 % Cl 1.06-1.30). No association was observed for the remainder of analysed exposures, although there was a weak association with birth weight below 3000 g (OR 1.19; 95 % CI 1.04-1.37), though not for "low birth weight" <2500 g (OR 0.90; 95 % CI 0.70-1.16). The increase in risk associated with having older siblings was consistent in a multivariate analysis adjusting for possible confounders (OR 1.23; 95 % Cl 1.09-1.39). The direction and magnitude of the point estimates were also consistent in several sensitivity analyses and when stratifying by sex.CONCLUSIONS: Having older siblings was associated with an increased risk for developing AS. These results need to be repeated and confirmed in other cohorts.

KW - Adult

KW - Birth Weight

KW - Case-Control Studies

KW - Female

KW - Humans

KW - Male

KW - Perinatal Care

KW - Pregnancy

KW - Registries

KW - Risk Factors

KW - Seasons

KW - Siblings

KW - Spondylitis, Ankylosing

KW - Sweden

KW - Young Adult

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1186/s13075-016-0917-1

DO - 10.1186/s13075-016-0917-1

M3 - Journal article

C2 - 26785608

VL - 18

JO - Arthritis Research & Therapy

JF - Arthritis Research & Therapy

SN - 1478-6354

M1 - 16

ER -

ID: 173986527