Prevalence and Risk of Inflammatory Bowel Disease in Patients with Hidradenitis Suppurativa

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Prevalence and Risk of Inflammatory Bowel Disease in Patients with Hidradenitis Suppurativa. / Egeberg, Alexander; Jemec, Gregor B E; Kimball, Alexa B; Bachelez, Hervé; Gislason, Gunnar H; Thyssen, Jacob P; Mallbris, Lotus.

In: Journal of Investigative Dermatology, Vol. 137, No. 5, 2017, p. 1060-1064.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Egeberg, A, Jemec, GBE, Kimball, AB, Bachelez, H, Gislason, GH, Thyssen, JP & Mallbris, L 2017, 'Prevalence and Risk of Inflammatory Bowel Disease in Patients with Hidradenitis Suppurativa', Journal of Investigative Dermatology, vol. 137, no. 5, pp. 1060-1064. https://doi.org/10.1016/j.jid.2016.11.040

APA

Egeberg, A., Jemec, G. B. E., Kimball, A. B., Bachelez, H., Gislason, G. H., Thyssen, J. P., & Mallbris, L. (2017). Prevalence and Risk of Inflammatory Bowel Disease in Patients with Hidradenitis Suppurativa. Journal of Investigative Dermatology, 137(5), 1060-1064. https://doi.org/10.1016/j.jid.2016.11.040

Vancouver

Egeberg A, Jemec GBE, Kimball AB, Bachelez H, Gislason GH, Thyssen JP et al. Prevalence and Risk of Inflammatory Bowel Disease in Patients with Hidradenitis Suppurativa. Journal of Investigative Dermatology. 2017;137(5):1060-1064. https://doi.org/10.1016/j.jid.2016.11.040

Author

Egeberg, Alexander ; Jemec, Gregor B E ; Kimball, Alexa B ; Bachelez, Hervé ; Gislason, Gunnar H ; Thyssen, Jacob P ; Mallbris, Lotus. / Prevalence and Risk of Inflammatory Bowel Disease in Patients with Hidradenitis Suppurativa. In: Journal of Investigative Dermatology. 2017 ; Vol. 137, No. 5. pp. 1060-1064.

Bibtex

@article{5352da94b21446e7a90338f89507e655,
title = "Prevalence and Risk of Inflammatory Bowel Disease in Patients with Hidradenitis Suppurativa",
abstract = "Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. In small studies, inflammatory bowel disease has been associated with the increased prevalence of HS, but the data on the concurrence of inflammatory bowel disease in patients with HS are limited. We therefore investigated the prevalence and risk of inflammatory bowel disease in patients with HS compared with the general population. The study linked all Danish individuals aged ≥18 years in nationwide registers. Adjusted odds ratios and adjusted hazard ratios were estimated by logistic regression and Cox regression, respectively. The study comprised 7,732 patients with HS and 4,354,137 subjects from the general population. The prevalence (HS vs. general population) was 0.8{\%} and 0.3{\%} (odds ratio 2.04; 1.59-2.62) for Crohn's disease and 1.3{\%} and 0.7{\%} (odds ratio 1.75; 1.44-2.13) for ulcerative colitis. The risk of new-onset Crohn's disease (hazard ratio 2.19; 1.44-3.34) and ulcerative colitis (hazard ratio 1.63; 1.18-2.27) was significantly increased among patients with HS. In conclusion, HS was significantly associated with the presence and risk of new-onset inflammatory bowel disease, although the prevalence remained low. Gastrointestinal complaints in patients with HS should warrant further clinical examination.",
keywords = "Adult, Aged, Colitis, Ulcerative/epidemiology, Crohn Disease/epidemiology, Denmark/epidemiology, Female, Follow-Up Studies, Hidradenitis Suppurativa/complications, Humans, Logistic Models, Male, Middle Aged, Prevalence, Proportional Hazards Models, Registries, Risk Factors",
author = "Alexander Egeberg and Jemec, {Gregor B E} and Kimball, {Alexa B} and Herv{\'e} Bachelez and Gislason, {Gunnar H} and Thyssen, {Jacob P} and Lotus Mallbris",
note = "Copyright {\circledC} 2017 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2017",
doi = "10.1016/j.jid.2016.11.040",
language = "English",
volume = "137",
pages = "1060--1064",
journal = "Journal of Investigative Dermatology",
issn = "0022-202X",
publisher = "nature publishing group",
number = "5",

}

RIS

TY - JOUR

T1 - Prevalence and Risk of Inflammatory Bowel Disease in Patients with Hidradenitis Suppurativa

AU - Egeberg, Alexander

AU - Jemec, Gregor B E

AU - Kimball, Alexa B

AU - Bachelez, Hervé

AU - Gislason, Gunnar H

AU - Thyssen, Jacob P

AU - Mallbris, Lotus

N1 - Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2017

Y1 - 2017

N2 - Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. In small studies, inflammatory bowel disease has been associated with the increased prevalence of HS, but the data on the concurrence of inflammatory bowel disease in patients with HS are limited. We therefore investigated the prevalence and risk of inflammatory bowel disease in patients with HS compared with the general population. The study linked all Danish individuals aged ≥18 years in nationwide registers. Adjusted odds ratios and adjusted hazard ratios were estimated by logistic regression and Cox regression, respectively. The study comprised 7,732 patients with HS and 4,354,137 subjects from the general population. The prevalence (HS vs. general population) was 0.8% and 0.3% (odds ratio 2.04; 1.59-2.62) for Crohn's disease and 1.3% and 0.7% (odds ratio 1.75; 1.44-2.13) for ulcerative colitis. The risk of new-onset Crohn's disease (hazard ratio 2.19; 1.44-3.34) and ulcerative colitis (hazard ratio 1.63; 1.18-2.27) was significantly increased among patients with HS. In conclusion, HS was significantly associated with the presence and risk of new-onset inflammatory bowel disease, although the prevalence remained low. Gastrointestinal complaints in patients with HS should warrant further clinical examination.

AB - Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. In small studies, inflammatory bowel disease has been associated with the increased prevalence of HS, but the data on the concurrence of inflammatory bowel disease in patients with HS are limited. We therefore investigated the prevalence and risk of inflammatory bowel disease in patients with HS compared with the general population. The study linked all Danish individuals aged ≥18 years in nationwide registers. Adjusted odds ratios and adjusted hazard ratios were estimated by logistic regression and Cox regression, respectively. The study comprised 7,732 patients with HS and 4,354,137 subjects from the general population. The prevalence (HS vs. general population) was 0.8% and 0.3% (odds ratio 2.04; 1.59-2.62) for Crohn's disease and 1.3% and 0.7% (odds ratio 1.75; 1.44-2.13) for ulcerative colitis. The risk of new-onset Crohn's disease (hazard ratio 2.19; 1.44-3.34) and ulcerative colitis (hazard ratio 1.63; 1.18-2.27) was significantly increased among patients with HS. In conclusion, HS was significantly associated with the presence and risk of new-onset inflammatory bowel disease, although the prevalence remained low. Gastrointestinal complaints in patients with HS should warrant further clinical examination.

KW - Adult

KW - Aged

KW - Colitis, Ulcerative/epidemiology

KW - Crohn Disease/epidemiology

KW - Denmark/epidemiology

KW - Female

KW - Follow-Up Studies

KW - Hidradenitis Suppurativa/complications

KW - Humans

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Prevalence

KW - Proportional Hazards Models

KW - Registries

KW - Risk Factors

U2 - 10.1016/j.jid.2016.11.040

DO - 10.1016/j.jid.2016.11.040

M3 - Journal article

C2 - 28089682

VL - 137

SP - 1060

EP - 1064

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

SN - 0022-202X

IS - 5

ER -

ID: 195501936