Serological Response to Treatment of Syphilis with Doxycycline Compared with Penicillin in HIV-infected Individuals

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Serological Response to Treatment of Syphilis with Doxycycline Compared with Penicillin in HIV-infected Individuals. / Salado-Rasmussen, Kirsten; Hoffmann, Steen; Cowan, Susan; Jensen, Jørgen Skov; Benfield, Thomas; Gerstoft, Jan; Katzenstein, Terese Lea.

In: Acta Dermatovenereologica, Vol. 96, No. 6, 2016, p. 807-811.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Salado-Rasmussen, K, Hoffmann, S, Cowan, S, Jensen, JS, Benfield, T, Gerstoft, J & Katzenstein, TL 2016, 'Serological Response to Treatment of Syphilis with Doxycycline Compared with Penicillin in HIV-infected Individuals', Acta Dermatovenereologica, vol. 96, no. 6, pp. 807-811. https://doi.org/10.2340/00015555-2289

APA

Salado-Rasmussen, K., Hoffmann, S., Cowan, S., Jensen, J. S., Benfield, T., Gerstoft, J., & Katzenstein, T. L. (2016). Serological Response to Treatment of Syphilis with Doxycycline Compared with Penicillin in HIV-infected Individuals. Acta Dermatovenereologica, 96(6), 807-811. https://doi.org/10.2340/00015555-2289

Vancouver

Salado-Rasmussen K, Hoffmann S, Cowan S, Jensen JS, Benfield T, Gerstoft J et al. Serological Response to Treatment of Syphilis with Doxycycline Compared with Penicillin in HIV-infected Individuals. Acta Dermatovenereologica. 2016;96(6):807-811. https://doi.org/10.2340/00015555-2289

Author

Salado-Rasmussen, Kirsten ; Hoffmann, Steen ; Cowan, Susan ; Jensen, Jørgen Skov ; Benfield, Thomas ; Gerstoft, Jan ; Katzenstein, Terese Lea. / Serological Response to Treatment of Syphilis with Doxycycline Compared with Penicillin in HIV-infected Individuals. In: Acta Dermatovenereologica. 2016 ; Vol. 96, No. 6. pp. 807-811.

Bibtex

@article{556716889acc481986662d4da358e790,
title = "Serological Response to Treatment of Syphilis with Doxycycline Compared with Penicillin in HIV-infected Individuals",
abstract = "Serological response to treatment of syphilis with orally administered doxycycline or intramuscularly administered penicillin was assessed in patients with concurrent HIV. All HIV-infected individuals diagnosed with syphilis attending 3 hospitals in Copenhagen, Denmark were included. Odds ratios (ORs) with 95{\%} confidence intervals (CI) associated with serological outcome were modelled using propensity-score-adjusted logistic regression analysis. In total, 202 cases were treated with doxycycline or intramuscular penicillin. At 12 months, serological failure was observed in 12 cases (15{\%}) treated with doxycycline and in 8 cases (17{\%}) treated with penicillin (OR 0.78 (95{\%} CI 0.16-3.88), p = 0.76). The serological cure rate at 12 months was highest in patients with primary syphilis (100{\%}), followed by patients with secondary (89{\%}), early latent (71{\%}) and late latent (67{\%}) syphilis (p = 0.006). In conclusion, this study provides evidence for the use of doxycycline as a treatment option when treating a HIV-infected population for syphilis.",
keywords = "Administration, Oral, Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents, Denmark, Doxycycline, Female, HIV Seropositivity, Humans, Injections, Male, Middle Aged, Penicillins, Retrospective Studies, Syphilis, Treatment Outcome, Comparative Study",
author = "Kirsten Salado-Rasmussen and Steen Hoffmann and Susan Cowan and Jensen, {J{\o}rgen Skov} and Thomas Benfield and Jan Gerstoft and Katzenstein, {Terese Lea}",
year = "2016",
doi = "10.2340/00015555-2289",
language = "English",
volume = "96",
pages = "807--811",
journal = "Acta Dermatovenereologica",
issn = "0001-5555",
publisher = "Society for the Publication of Acta Dermato - Venereologica",
number = "6",

}

RIS

TY - JOUR

T1 - Serological Response to Treatment of Syphilis with Doxycycline Compared with Penicillin in HIV-infected Individuals

AU - Salado-Rasmussen, Kirsten

AU - Hoffmann, Steen

AU - Cowan, Susan

AU - Jensen, Jørgen Skov

AU - Benfield, Thomas

AU - Gerstoft, Jan

AU - Katzenstein, Terese Lea

PY - 2016

Y1 - 2016

N2 - Serological response to treatment of syphilis with orally administered doxycycline or intramuscularly administered penicillin was assessed in patients with concurrent HIV. All HIV-infected individuals diagnosed with syphilis attending 3 hospitals in Copenhagen, Denmark were included. Odds ratios (ORs) with 95% confidence intervals (CI) associated with serological outcome were modelled using propensity-score-adjusted logistic regression analysis. In total, 202 cases were treated with doxycycline or intramuscular penicillin. At 12 months, serological failure was observed in 12 cases (15%) treated with doxycycline and in 8 cases (17%) treated with penicillin (OR 0.78 (95% CI 0.16-3.88), p = 0.76). The serological cure rate at 12 months was highest in patients with primary syphilis (100%), followed by patients with secondary (89%), early latent (71%) and late latent (67%) syphilis (p = 0.006). In conclusion, this study provides evidence for the use of doxycycline as a treatment option when treating a HIV-infected population for syphilis.

AB - Serological response to treatment of syphilis with orally administered doxycycline or intramuscularly administered penicillin was assessed in patients with concurrent HIV. All HIV-infected individuals diagnosed with syphilis attending 3 hospitals in Copenhagen, Denmark were included. Odds ratios (ORs) with 95% confidence intervals (CI) associated with serological outcome were modelled using propensity-score-adjusted logistic regression analysis. In total, 202 cases were treated with doxycycline or intramuscular penicillin. At 12 months, serological failure was observed in 12 cases (15%) treated with doxycycline and in 8 cases (17%) treated with penicillin (OR 0.78 (95% CI 0.16-3.88), p = 0.76). The serological cure rate at 12 months was highest in patients with primary syphilis (100%), followed by patients with secondary (89%), early latent (71%) and late latent (67%) syphilis (p = 0.006). In conclusion, this study provides evidence for the use of doxycycline as a treatment option when treating a HIV-infected population for syphilis.

KW - Administration, Oral

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Anti-Bacterial Agents

KW - Denmark

KW - Doxycycline

KW - Female

KW - HIV Seropositivity

KW - Humans

KW - Injections

KW - Male

KW - Middle Aged

KW - Penicillins

KW - Retrospective Studies

KW - Syphilis

KW - Treatment Outcome

KW - Comparative Study

U2 - 10.2340/00015555-2289

DO - 10.2340/00015555-2289

M3 - Journal article

C2 - 26568359

VL - 96

SP - 807

EP - 811

JO - Acta Dermatovenereologica

JF - Acta Dermatovenereologica

SN - 0001-5555

IS - 6

ER -

ID: 173675418