Serum cytokine profile and clinicopathological findings in oral lichen planus, oral lichenoid lesions and stomatitis

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Serum cytokine profile and clinicopathological findings in oral lichen planus, oral lichenoid lesions and stomatitis. / Larsen, Kristine Røn; Johansen, Jeanne Duus; Reibel, Jesper; Zachariae, Claus; Pedersen, Anne Marie Lynge.

In: Clinical and Experimental Dental Research, No. 3, 12.2017, p. 220-226.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Larsen, KR, Johansen, JD, Reibel, J, Zachariae, C & Pedersen, AML 2017, 'Serum cytokine profile and clinicopathological findings in oral lichen planus, oral lichenoid lesions and stomatitis', Clinical and Experimental Dental Research, no. 3, pp. 220-226. https://doi.org/10.1002/cre2.91

APA

Larsen, K. R., Johansen, J. D., Reibel, J., Zachariae, C., & Pedersen, A. M. L. (2017). Serum cytokine profile and clinicopathological findings in oral lichen planus, oral lichenoid lesions and stomatitis. Clinical and Experimental Dental Research, (3), 220-226. https://doi.org/10.1002/cre2.91

Vancouver

Larsen KR, Johansen JD, Reibel J, Zachariae C, Pedersen AML. Serum cytokine profile and clinicopathological findings in oral lichen planus, oral lichenoid lesions and stomatitis. Clinical and Experimental Dental Research. 2017 Dec;(3):220-226. https://doi.org/10.1002/cre2.91

Author

Larsen, Kristine Røn ; Johansen, Jeanne Duus ; Reibel, Jesper ; Zachariae, Claus ; Pedersen, Anne Marie Lynge. / Serum cytokine profile and clinicopathological findings in oral lichen planus, oral lichenoid lesions and stomatitis. In: Clinical and Experimental Dental Research. 2017 ; No. 3. pp. 220-226.

Bibtex

@article{93d41ff23d1840d99c5f4db604769b18,
title = "Serum cytokine profile and clinicopathological findings in oral lichen planus, oral lichenoid lesions and stomatitis",
abstract = "The objective of this study was to examine if clinical and histopathological variables in patients with oral lichen planus (OLP), oral lichenoid lesions (OLL), and generalized stomatitis display different cytokine profiles and if concomitant contact allergy influences this profile. Forty-nine patients and 29 healthy age- and gender-matched subjects were included. Demographic and clinical data immunohistochemical findings in mucosal specimens, results of contact allergy testing, and serum levels of tumor necrosis factor-α, interferon-γ, interleukin (IL)-6, IL-10, IL-12p40, and IL-12p70 were analyzed and compared between groups. Nineteen patients had OLP, primarily with ulcerative lesions on the buccal mucosa, 19 patients had OLL, and 11 patients had generalized stomatitis. All patients had oral symptoms, mainly stinging and burning. Nineteen patients and 10 healthy subjects had contact allergies, primarily to fragrance ingredients. Patient groups did not differ with regard to oral symptoms, clinical pattern of the lesions, or contact allergy. Serum cytokine levels did not differ between the different patient groups and were not related to histopathological findings. The patients had higher levels of IL-6 than the healthy subjects. Interferon-γ, IL-12p40, and IL-12p70 were below detection limit. Our findings indicate that OLP, OLL, and generalized stomatitis cannot be discriminated by means of the selected serum cytokines, and that the presence of concomitant contact allergy does not influence the cytokine expression",
author = "Larsen, {Kristine R{\o}n} and Johansen, {Jeanne Duus} and Jesper Reibel and Claus Zachariae and Pedersen, {Anne Marie Lynge}",
year = "2017",
month = "12",
doi = "10.1002/cre2.91",
language = "English",
pages = "220--226",
journal = "Clinical and Experimental Dental Research",
issn = "2057-4347",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Serum cytokine profile and clinicopathological findings in oral lichen planus, oral lichenoid lesions and stomatitis

AU - Larsen, Kristine Røn

AU - Johansen, Jeanne Duus

AU - Reibel, Jesper

AU - Zachariae, Claus

AU - Pedersen, Anne Marie Lynge

PY - 2017/12

Y1 - 2017/12

N2 - The objective of this study was to examine if clinical and histopathological variables in patients with oral lichen planus (OLP), oral lichenoid lesions (OLL), and generalized stomatitis display different cytokine profiles and if concomitant contact allergy influences this profile. Forty-nine patients and 29 healthy age- and gender-matched subjects were included. Demographic and clinical data immunohistochemical findings in mucosal specimens, results of contact allergy testing, and serum levels of tumor necrosis factor-α, interferon-γ, interleukin (IL)-6, IL-10, IL-12p40, and IL-12p70 were analyzed and compared between groups. Nineteen patients had OLP, primarily with ulcerative lesions on the buccal mucosa, 19 patients had OLL, and 11 patients had generalized stomatitis. All patients had oral symptoms, mainly stinging and burning. Nineteen patients and 10 healthy subjects had contact allergies, primarily to fragrance ingredients. Patient groups did not differ with regard to oral symptoms, clinical pattern of the lesions, or contact allergy. Serum cytokine levels did not differ between the different patient groups and were not related to histopathological findings. The patients had higher levels of IL-6 than the healthy subjects. Interferon-γ, IL-12p40, and IL-12p70 were below detection limit. Our findings indicate that OLP, OLL, and generalized stomatitis cannot be discriminated by means of the selected serum cytokines, and that the presence of concomitant contact allergy does not influence the cytokine expression

AB - The objective of this study was to examine if clinical and histopathological variables in patients with oral lichen planus (OLP), oral lichenoid lesions (OLL), and generalized stomatitis display different cytokine profiles and if concomitant contact allergy influences this profile. Forty-nine patients and 29 healthy age- and gender-matched subjects were included. Demographic and clinical data immunohistochemical findings in mucosal specimens, results of contact allergy testing, and serum levels of tumor necrosis factor-α, interferon-γ, interleukin (IL)-6, IL-10, IL-12p40, and IL-12p70 were analyzed and compared between groups. Nineteen patients had OLP, primarily with ulcerative lesions on the buccal mucosa, 19 patients had OLL, and 11 patients had generalized stomatitis. All patients had oral symptoms, mainly stinging and burning. Nineteen patients and 10 healthy subjects had contact allergies, primarily to fragrance ingredients. Patient groups did not differ with regard to oral symptoms, clinical pattern of the lesions, or contact allergy. Serum cytokine levels did not differ between the different patient groups and were not related to histopathological findings. The patients had higher levels of IL-6 than the healthy subjects. Interferon-γ, IL-12p40, and IL-12p70 were below detection limit. Our findings indicate that OLP, OLL, and generalized stomatitis cannot be discriminated by means of the selected serum cytokines, and that the presence of concomitant contact allergy does not influence the cytokine expression

U2 - 10.1002/cre2.91

DO - 10.1002/cre2.91

M3 - Journal article

C2 - 29744205

SP - 220

EP - 226

JO - Clinical and Experimental Dental Research

JF - Clinical and Experimental Dental Research

SN - 2057-4347

IS - 3

ER -

ID: 185991978