The association between null mutations in the filaggrin gene and contact sensitization to nickel and other chemicals in the general population

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The association between null mutations in the filaggrin gene and contact sensitization to nickel and other chemicals in the general population. / Thyssen, J P; Johansen, J D; Linneberg, A; Menné, T; Nielsen, N H; Meldgaard, M; Szecsi, P B; Stender, S; Carlsen, B C; Stender, Steen.

In: British Journal of Dermatology, Vol. 162, No. 6, 01.06.2010, p. 1278-85.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Thyssen, JP, Johansen, JD, Linneberg, A, Menné, T, Nielsen, NH, Meldgaard, M, Szecsi, PB, Stender, S, Carlsen, BC & Stender, S 2010, 'The association between null mutations in the filaggrin gene and contact sensitization to nickel and other chemicals in the general population', British Journal of Dermatology, vol. 162, no. 6, pp. 1278-85. https://doi.org/10.1111/j.1365-2133.2010.09708.x

APA

Thyssen, J. P., Johansen, J. D., Linneberg, A., Menné, T., Nielsen, N. H., Meldgaard, M., ... Stender, S. (2010). The association between null mutations in the filaggrin gene and contact sensitization to nickel and other chemicals in the general population. British Journal of Dermatology, 162(6), 1278-85. https://doi.org/10.1111/j.1365-2133.2010.09708.x

Vancouver

Thyssen JP, Johansen JD, Linneberg A, Menné T, Nielsen NH, Meldgaard M et al. The association between null mutations in the filaggrin gene and contact sensitization to nickel and other chemicals in the general population. British Journal of Dermatology. 2010 Jun 1;162(6):1278-85. https://doi.org/10.1111/j.1365-2133.2010.09708.x

Author

Thyssen, J P ; Johansen, J D ; Linneberg, A ; Menné, T ; Nielsen, N H ; Meldgaard, M ; Szecsi, P B ; Stender, S ; Carlsen, B C ; Stender, Steen. / The association between null mutations in the filaggrin gene and contact sensitization to nickel and other chemicals in the general population. In: British Journal of Dermatology. 2010 ; Vol. 162, No. 6. pp. 1278-85.

Bibtex

@article{96d936559e534555bd14fc9e2f6357c8,
title = "The association between null mutations in the filaggrin gene and contact sensitization to nickel and other chemicals in the general population",
abstract = "It was recently shown that filaggrin gene (FLG) null mutations are positively associated with nickel sensitization. We have hypothesized that histidine-rich filaggrin proteins in the epidermis chelate nickel ions and prevent their skin penetration and exposure to Langerhans cells. Furthermore, we have proposed that the low degree of genetic predisposition to nickel sensitization found by a Danish twin study was explained by a high prevalence of ear piercing among participants resulting in 'bypassing' of the filaggrin proteins.",
author = "Thyssen, {J P} and Johansen, {J D} and A Linneberg and T Menn{\'e} and Nielsen, {N H} and M Meldgaard and Szecsi, {P B} and S Stender and Carlsen, {B C} and Steen Stender",
note = "{\circledC} 2010 The Authors. Journal Compilation {\circledC} 2010 British Association of Dermatologists.",
year = "2010",
month = "6",
day = "1",
doi = "http://dx.doi.org/10.1111/j.1365-2133.2010.09708.x",
language = "English",
volume = "162",
pages = "1278--85",
journal = "British Journal of Dermatology",
issn = "0007-0963",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - The association between null mutations in the filaggrin gene and contact sensitization to nickel and other chemicals in the general population

AU - Thyssen, J P

AU - Johansen, J D

AU - Linneberg, A

AU - Menné, T

AU - Nielsen, N H

AU - Meldgaard, M

AU - Szecsi, P B

AU - Stender, S

AU - Carlsen, B C

AU - Stender, Steen

N1 - © 2010 The Authors. Journal Compilation © 2010 British Association of Dermatologists.

PY - 2010/6/1

Y1 - 2010/6/1

N2 - It was recently shown that filaggrin gene (FLG) null mutations are positively associated with nickel sensitization. We have hypothesized that histidine-rich filaggrin proteins in the epidermis chelate nickel ions and prevent their skin penetration and exposure to Langerhans cells. Furthermore, we have proposed that the low degree of genetic predisposition to nickel sensitization found by a Danish twin study was explained by a high prevalence of ear piercing among participants resulting in 'bypassing' of the filaggrin proteins.

AB - It was recently shown that filaggrin gene (FLG) null mutations are positively associated with nickel sensitization. We have hypothesized that histidine-rich filaggrin proteins in the epidermis chelate nickel ions and prevent their skin penetration and exposure to Langerhans cells. Furthermore, we have proposed that the low degree of genetic predisposition to nickel sensitization found by a Danish twin study was explained by a high prevalence of ear piercing among participants resulting in 'bypassing' of the filaggrin proteins.

U2 - http://dx.doi.org/10.1111/j.1365-2133.2010.09708.x

DO - http://dx.doi.org/10.1111/j.1365-2133.2010.09708.x

M3 - Journal article

VL - 162

SP - 1278

EP - 1285

JO - British Journal of Dermatology

JF - British Journal of Dermatology

SN - 0007-0963

IS - 6

ER -

ID: 34093853