The biology of glucagon and the consequences of hyperglucagonemia

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The biology of glucagon and the consequences of hyperglucagonemia. / Wewer Albrechtsen, Nicolai J; Kuhre, Rune E; Pedersen, Jens; Knop, Filip K; Holst, Jens J.

In: Biomarkers in Medicine, Vol. 10, No. 11, 09.09.2016, p. 1141-1151.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Wewer Albrechtsen, NJ, Kuhre, RE, Pedersen, J, Knop, FK & Holst, JJ 2016, 'The biology of glucagon and the consequences of hyperglucagonemia', Biomarkers in Medicine, vol. 10, no. 11, pp. 1141-1151. https://doi.org/10.2217/bmm-2016-0090

APA

Wewer Albrechtsen, N. J., Kuhre, R. E., Pedersen, J., Knop, F. K., & Holst, J. J. (2016). The biology of glucagon and the consequences of hyperglucagonemia. Biomarkers in Medicine, 10(11), 1141-1151. https://doi.org/10.2217/bmm-2016-0090

Vancouver

Wewer Albrechtsen NJ, Kuhre RE, Pedersen J, Knop FK, Holst JJ. The biology of glucagon and the consequences of hyperglucagonemia. Biomarkers in Medicine. 2016 Sep 9;10(11):1141-1151. https://doi.org/10.2217/bmm-2016-0090

Author

Wewer Albrechtsen, Nicolai J ; Kuhre, Rune E ; Pedersen, Jens ; Knop, Filip K ; Holst, Jens J. / The biology of glucagon and the consequences of hyperglucagonemia. In: Biomarkers in Medicine. 2016 ; Vol. 10, No. 11. pp. 1141-1151.

Bibtex

@article{5ddadb13ee6b4da0b4398c1fcff20823,
title = "The biology of glucagon and the consequences of hyperglucagonemia",
abstract = "The proglucagon-derived peptide hormone, glucagon, comprises 29 amino acids. Its secretion from the pancreatic α cells is regulated by several factors. Glucagon increases blood glucose levels through gluconeogenesis and glycogenolysis. Elevated plasma concentrations of glucagon, hyperglucagonemia, may contribute to diabetes. However, hyperglucagonemia is also observed in other clinical conditions than diabetes, including nonalcoholic fatty liver disease, glucagon-producing tumors and after gastric bypass surgery. Here, we review the current literature on hyperglucagonemia in disease with a particular focus on diabetes, and finally speculate that the primary physiological importance of glucagon may not reside in glucose homeostasis but in regulation of amino acid metabolism exerted via a hitherto unrecognized hepato-pancreatic feedback loop.",
author = "{Wewer Albrechtsen}, {Nicolai J} and Kuhre, {Rune E} and Jens Pedersen and Knop, {Filip K} and Holst, {Jens J}",
year = "2016",
month = "9",
day = "9",
doi = "10.2217/bmm-2016-0090",
language = "English",
volume = "10",
pages = "1141--1151",
journal = "Biomarkers in Medicine",
issn = "1752-0363",
publisher = "Future Medicine Ltd.",
number = "11",

}

RIS

TY - JOUR

T1 - The biology of glucagon and the consequences of hyperglucagonemia

AU - Wewer Albrechtsen, Nicolai J

AU - Kuhre, Rune E

AU - Pedersen, Jens

AU - Knop, Filip K

AU - Holst, Jens J

PY - 2016/9/9

Y1 - 2016/9/9

N2 - The proglucagon-derived peptide hormone, glucagon, comprises 29 amino acids. Its secretion from the pancreatic α cells is regulated by several factors. Glucagon increases blood glucose levels through gluconeogenesis and glycogenolysis. Elevated plasma concentrations of glucagon, hyperglucagonemia, may contribute to diabetes. However, hyperglucagonemia is also observed in other clinical conditions than diabetes, including nonalcoholic fatty liver disease, glucagon-producing tumors and after gastric bypass surgery. Here, we review the current literature on hyperglucagonemia in disease with a particular focus on diabetes, and finally speculate that the primary physiological importance of glucagon may not reside in glucose homeostasis but in regulation of amino acid metabolism exerted via a hitherto unrecognized hepato-pancreatic feedback loop.

AB - The proglucagon-derived peptide hormone, glucagon, comprises 29 amino acids. Its secretion from the pancreatic α cells is regulated by several factors. Glucagon increases blood glucose levels through gluconeogenesis and glycogenolysis. Elevated plasma concentrations of glucagon, hyperglucagonemia, may contribute to diabetes. However, hyperglucagonemia is also observed in other clinical conditions than diabetes, including nonalcoholic fatty liver disease, glucagon-producing tumors and after gastric bypass surgery. Here, we review the current literature on hyperglucagonemia in disease with a particular focus on diabetes, and finally speculate that the primary physiological importance of glucagon may not reside in glucose homeostasis but in regulation of amino acid metabolism exerted via a hitherto unrecognized hepato-pancreatic feedback loop.

U2 - 10.2217/bmm-2016-0090

DO - 10.2217/bmm-2016-0090

M3 - Journal article

C2 - 27611762

VL - 10

SP - 1141

EP - 1151

JO - Biomarkers in Medicine

JF - Biomarkers in Medicine

SN - 1752-0363

IS - 11

ER -

ID: 165941600