The KATP channel in migraine pathophysiology: a novel therapeutic target for migraine

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

The KATP channel in migraine pathophysiology : a novel therapeutic target for migraine. / Al-Karagholi, Mohammad Al-Mahdi; Hansen, Jakob Møller; Severinsen, Johanne; Jansen-Olesen, Inger; Ashina, Messoud.

In: Journal of Headache and Pain, Vol. 18, 90, 23.08.2017.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Al-Karagholi, MA-M, Hansen, JM, Severinsen, J, Jansen-Olesen, I & Ashina, M 2017, 'The KATP channel in migraine pathophysiology: a novel therapeutic target for migraine', Journal of Headache and Pain, vol. 18, 90. https://doi.org/10.1186/s10194-017-0800-8

APA

Al-Karagholi, M. A-M., Hansen, J. M., Severinsen, J., Jansen-Olesen, I., & Ashina, M. (2017). The KATP channel in migraine pathophysiology: a novel therapeutic target for migraine. Journal of Headache and Pain, 18, [90]. https://doi.org/10.1186/s10194-017-0800-8

Vancouver

Al-Karagholi MA-M, Hansen JM, Severinsen J, Jansen-Olesen I, Ashina M. The KATP channel in migraine pathophysiology: a novel therapeutic target for migraine. Journal of Headache and Pain. 2017 Aug 23;18. 90. https://doi.org/10.1186/s10194-017-0800-8

Author

Al-Karagholi, Mohammad Al-Mahdi ; Hansen, Jakob Møller ; Severinsen, Johanne ; Jansen-Olesen, Inger ; Ashina, Messoud. / The KATP channel in migraine pathophysiology : a novel therapeutic target for migraine. In: Journal of Headache and Pain. 2017 ; Vol. 18.

Bibtex

@article{4210da436e974099b8f0cfbf78cc2cba,
title = "The KATP channel in migraine pathophysiology: a novel therapeutic target for migraine",
abstract = "BACKGROUND: To review the distribution and function of KATP channels, describe the use of KATP channels openers in clinical trials and make the case that these channels may play a role in headache and migraine.DISCUSSION: KATP channels are widely present in the trigeminovascular system and play an important role in the regulation of tone in cerebral and meningeal arteries. Clinical trials using synthetic KATP channel openers report headache as a prevalent-side effect in non-migraine sufferers, indicating that KATP channel opening may cause headache, possibly due to vascular mechanisms. Whether KATP channel openers can provoke migraine in migraine sufferers is not known.CONCLUSION: We suggest that KATP channels may play an important role in migraine pathogenesis and could be a potential novel therapeutic anti-migraine target.",
keywords = "Journal Article",
author = "Al-Karagholi, {Mohammad Al-Mahdi} and Hansen, {Jakob M{\o}ller} and Johanne Severinsen and Inger Jansen-Olesen and Messoud Ashina",
year = "2017",
month = "8",
day = "23",
doi = "10.1186/s10194-017-0800-8",
language = "English",
volume = "18",
journal = "Journal of Headache and Pain",
issn = "1129-2369",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - The KATP channel in migraine pathophysiology

T2 - a novel therapeutic target for migraine

AU - Al-Karagholi, Mohammad Al-Mahdi

AU - Hansen, Jakob Møller

AU - Severinsen, Johanne

AU - Jansen-Olesen, Inger

AU - Ashina, Messoud

PY - 2017/8/23

Y1 - 2017/8/23

N2 - BACKGROUND: To review the distribution and function of KATP channels, describe the use of KATP channels openers in clinical trials and make the case that these channels may play a role in headache and migraine.DISCUSSION: KATP channels are widely present in the trigeminovascular system and play an important role in the regulation of tone in cerebral and meningeal arteries. Clinical trials using synthetic KATP channel openers report headache as a prevalent-side effect in non-migraine sufferers, indicating that KATP channel opening may cause headache, possibly due to vascular mechanisms. Whether KATP channel openers can provoke migraine in migraine sufferers is not known.CONCLUSION: We suggest that KATP channels may play an important role in migraine pathogenesis and could be a potential novel therapeutic anti-migraine target.

AB - BACKGROUND: To review the distribution and function of KATP channels, describe the use of KATP channels openers in clinical trials and make the case that these channels may play a role in headache and migraine.DISCUSSION: KATP channels are widely present in the trigeminovascular system and play an important role in the regulation of tone in cerebral and meningeal arteries. Clinical trials using synthetic KATP channel openers report headache as a prevalent-side effect in non-migraine sufferers, indicating that KATP channel opening may cause headache, possibly due to vascular mechanisms. Whether KATP channel openers can provoke migraine in migraine sufferers is not known.CONCLUSION: We suggest that KATP channels may play an important role in migraine pathogenesis and could be a potential novel therapeutic anti-migraine target.

KW - Journal Article

U2 - 10.1186/s10194-017-0800-8

DO - 10.1186/s10194-017-0800-8

M3 - Journal article

C2 - 28831746

VL - 18

JO - Journal of Headache and Pain

JF - Journal of Headache and Pain

SN - 1129-2369

M1 - 90

ER -

ID: 185366795