The miRNA Plasma Signature in Response to Acute Aerobic Exercise and Endurance Training

Research output: Contribution to journalJournal articleResearchpeer-review

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The miRNA Plasma Signature in Response to Acute Aerobic Exercise and Endurance Training. / Nielsen, Søren; Åkerström, Thorbjörn; Rinnov, Anders; Yfanti, Christina; Schéele, Camilla Charlotte; Pedersen, Bente Klarlund; Laye, Matthew James.

In: P L o S One, Vol. 9, No. 2, e87308, 2014.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Nielsen, S, Åkerström, T, Rinnov, A, Yfanti, C, Schéele, CC, Pedersen, BK & Laye, MJ 2014, 'The miRNA Plasma Signature in Response to Acute Aerobic Exercise and Endurance Training', P L o S One, vol. 9, no. 2, e87308. https://doi.org/10.1371/journal.pone.0087308

APA

Nielsen, S., Åkerström, T., Rinnov, A., Yfanti, C., Schéele, C. C., Pedersen, B. K., & Laye, M. J. (2014). The miRNA Plasma Signature in Response to Acute Aerobic Exercise and Endurance Training. P L o S One, 9(2), [e87308]. https://doi.org/10.1371/journal.pone.0087308

Vancouver

Nielsen S, Åkerström T, Rinnov A, Yfanti C, Schéele CC, Pedersen BK et al. The miRNA Plasma Signature in Response to Acute Aerobic Exercise and Endurance Training. P L o S One. 2014;9(2). e87308. https://doi.org/10.1371/journal.pone.0087308

Author

Nielsen, Søren ; Åkerström, Thorbjörn ; Rinnov, Anders ; Yfanti, Christina ; Schéele, Camilla Charlotte ; Pedersen, Bente Klarlund ; Laye, Matthew James. / The miRNA Plasma Signature in Response to Acute Aerobic Exercise and Endurance Training. In: P L o S One. 2014 ; Vol. 9, No. 2.

Bibtex

@article{8884d82d14474694836a0d9664ec0694,
title = "The miRNA Plasma Signature in Response to Acute Aerobic Exercise and Endurance Training",
abstract = "MiRNAs are potent intracellular posttranscriptional regulators and are also selectively secreted into the circulation in a cell-specific fashion. Global changes in miRNA expression in skeletal muscle in response to endurance exercise training have been reported. Therefore, our aim was to establish the miRNA signature in human plasma in response to acute exercise and chronic endurance training by utilizing a novel methodological approach. RNA was isolated from human plasma collected from young healthy men before and after an acute endurance exercise bout and following 12 weeks of endurance training. Global miRNA (742 miRNAs) measurements were performed as a screening to identify detectable miRNAs in plasma. Using customized qPCR panels we quantified the expression levels of miRNAs detected in the screening procedure (188 miRNAs). We demonstrate a dynamic regulation of circulating miRNA (ci-miRNA) levels following 0 hour (miR-106a, miR-221, miR-30b, miR-151-5p, let-7i, miR-146, miR-652 and miR-151-3p), 1 hour (miR-338-3p, miR-330-3p, miR-223, miR-139-5p and miR-143) and 3 hours (miR-1) after an acute exercise bout (P",
author = "S{\o}ren Nielsen and Thorbj{\"o}rn {\AA}kerstr{\"o}m and Anders Rinnov and Christina Yfanti and Sch{\'e}ele, {Camilla Charlotte} and Pedersen, {Bente Klarlund} and Laye, {Matthew James}",
note = "CURIS 2014 NEXS 092",
year = "2014",
doi = "10.1371/journal.pone.0087308",
language = "English",
volume = "9",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "2",

}

RIS

TY - JOUR

T1 - The miRNA Plasma Signature in Response to Acute Aerobic Exercise and Endurance Training

AU - Nielsen, Søren

AU - Åkerström, Thorbjörn

AU - Rinnov, Anders

AU - Yfanti, Christina

AU - Schéele, Camilla Charlotte

AU - Pedersen, Bente Klarlund

AU - Laye, Matthew James

N1 - CURIS 2014 NEXS 092

PY - 2014

Y1 - 2014

N2 - MiRNAs are potent intracellular posttranscriptional regulators and are also selectively secreted into the circulation in a cell-specific fashion. Global changes in miRNA expression in skeletal muscle in response to endurance exercise training have been reported. Therefore, our aim was to establish the miRNA signature in human plasma in response to acute exercise and chronic endurance training by utilizing a novel methodological approach. RNA was isolated from human plasma collected from young healthy men before and after an acute endurance exercise bout and following 12 weeks of endurance training. Global miRNA (742 miRNAs) measurements were performed as a screening to identify detectable miRNAs in plasma. Using customized qPCR panels we quantified the expression levels of miRNAs detected in the screening procedure (188 miRNAs). We demonstrate a dynamic regulation of circulating miRNA (ci-miRNA) levels following 0 hour (miR-106a, miR-221, miR-30b, miR-151-5p, let-7i, miR-146, miR-652 and miR-151-3p), 1 hour (miR-338-3p, miR-330-3p, miR-223, miR-139-5p and miR-143) and 3 hours (miR-1) after an acute exercise bout (P

AB - MiRNAs are potent intracellular posttranscriptional regulators and are also selectively secreted into the circulation in a cell-specific fashion. Global changes in miRNA expression in skeletal muscle in response to endurance exercise training have been reported. Therefore, our aim was to establish the miRNA signature in human plasma in response to acute exercise and chronic endurance training by utilizing a novel methodological approach. RNA was isolated from human plasma collected from young healthy men before and after an acute endurance exercise bout and following 12 weeks of endurance training. Global miRNA (742 miRNAs) measurements were performed as a screening to identify detectable miRNAs in plasma. Using customized qPCR panels we quantified the expression levels of miRNAs detected in the screening procedure (188 miRNAs). We demonstrate a dynamic regulation of circulating miRNA (ci-miRNA) levels following 0 hour (miR-106a, miR-221, miR-30b, miR-151-5p, let-7i, miR-146, miR-652 and miR-151-3p), 1 hour (miR-338-3p, miR-330-3p, miR-223, miR-139-5p and miR-143) and 3 hours (miR-1) after an acute exercise bout (P

U2 - 10.1371/journal.pone.0087308

DO - 10.1371/journal.pone.0087308

M3 - Journal article

C2 - 24586268

VL - 9

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 2

M1 - e87308

ER -

ID: 105481574