Associations of neural processing of reward with posttraumatic stress disorder and secondary psychotic symptoms in trauma-affected refugees: Asociaciones de procesamiento neuronal de recompensa con trastorno de estrés postraumático y síntomas psicóticos secundarios en refugiados afectados por trauma

Research output: Contribution to journalJournal articlepeer-review

Standard

Associations of neural processing of reward with posttraumatic stress disorder and secondary psychotic symptoms in trauma-affected refugees : Asociaciones de procesamiento neuronal de recompensa con trastorno de estrés postraumático y síntomas psicóticos secundarios en refugiados afectados por trauma. / Uldall, Sigurd Wiingaard; Nielsen, Mette Ødegaard; Carlsson, Jessica; Glenthøj, Birte; Siebner, Hartwig Roman; Madsen, Kristoffer Hougaard; Madsen, Camilla Gøbel; Leffers, Anne Mette; Nejad, Ayna Baladi; Rostrup, Egill.

In: European Journal of Psychotraumatology, Vol. 11, No. 1, 1730091, 03.2020.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Uldall, SW, Nielsen, MØ, Carlsson, J, Glenthøj, B, Siebner, HR, Madsen, KH, Madsen, CG, Leffers, AM, Nejad, AB & Rostrup, E 2020, 'Associations of neural processing of reward with posttraumatic stress disorder and secondary psychotic symptoms in trauma-affected refugees: Asociaciones de procesamiento neuronal de recompensa con trastorno de estrés postraumático y síntomas psicóticos secundarios en refugiados afectados por trauma', European Journal of Psychotraumatology, vol. 11, no. 1, 1730091. https://doi.org/10.1080/20008198.2020.1730091

APA

Uldall, S. W., Nielsen, M. Ø., Carlsson, J., Glenthøj, B., Siebner, H. R., Madsen, K. H., Madsen, C. G., Leffers, A. M., Nejad, A. B., & Rostrup, E. (2020). Associations of neural processing of reward with posttraumatic stress disorder and secondary psychotic symptoms in trauma-affected refugees: Asociaciones de procesamiento neuronal de recompensa con trastorno de estrés postraumático y síntomas psicóticos secundarios en refugiados afectados por trauma. European Journal of Psychotraumatology, 11(1), [1730091]. https://doi.org/10.1080/20008198.2020.1730091

Vancouver

Uldall SW, Nielsen MØ, Carlsson J, Glenthøj B, Siebner HR, Madsen KH et al. Associations of neural processing of reward with posttraumatic stress disorder and secondary psychotic symptoms in trauma-affected refugees: Asociaciones de procesamiento neuronal de recompensa con trastorno de estrés postraumático y síntomas psicóticos secundarios en refugiados afectados por trauma. European Journal of Psychotraumatology. 2020 Mar;11(1). 1730091. https://doi.org/10.1080/20008198.2020.1730091

Author

Uldall, Sigurd Wiingaard ; Nielsen, Mette Ødegaard ; Carlsson, Jessica ; Glenthøj, Birte ; Siebner, Hartwig Roman ; Madsen, Kristoffer Hougaard ; Madsen, Camilla Gøbel ; Leffers, Anne Mette ; Nejad, Ayna Baladi ; Rostrup, Egill. / Associations of neural processing of reward with posttraumatic stress disorder and secondary psychotic symptoms in trauma-affected refugees : Asociaciones de procesamiento neuronal de recompensa con trastorno de estrés postraumático y síntomas psicóticos secundarios en refugiados afectados por trauma. In: European Journal of Psychotraumatology. 2020 ; Vol. 11, No. 1.

Bibtex

@article{7c340a2cd0c94eadaa48badcbcb5d8eb,
title = "Associations of neural processing of reward with posttraumatic stress disorder and secondary psychotic symptoms in trauma-affected refugees: Asociaciones de procesamiento neuronal de recompensa con trastorno de estr{\'e}s postraum{\'a}tico y s{\'i}ntomas psic{\'o}ticos secundarios en refugiados afectados por trauma",
abstract = "Background: Psychological traumatic experiences can lead to posttraumatic stress disorder (PTSD). Secondary psychotic symptoms are not common but may occur. Objectives: Since psychotic symptoms of schizophrenia have been related to aberrant reward processing in the striatum, using the same paradigm we investigate whether the same finding extends to psychotic and anhedonic symptoms in PTSD. Methods: A total of 70 male refugees: 18 PTSD patients with no secondary psychotic symptoms (PTSD-NSP), 21 PTSD patients with secondary psychotic symptoms (PTSD-SP), and 31 healthy controls (RHC) were interviewed and scanned with functional magnetic resonance imaging (fMRI) during a monetary incentive delay task. Using region of interest analysis of the prefrontal cortex and ventral striatum, we investigated reward-related activity. Results: Compared to RHC, participants with PTSD had decreased neural activity during monetary reward. Also, participants with PTSD-SP exhibited decreased activity in the associative striatum relative to participants with PTSD-NSP during processing of motivational reward anticipation which correlated with severity of psychotic symptoms. However, the difference between the two PTSD groups disappeared when PTSD severity and trauma exposure were accounted for. Conclusions: Anhedonia and secondary psychotic symptoms in PTSD are characterized by dysfunctional reward consumption and anticipation processing, respectively. The latter may reflect a mechanism by which abnormal reward signals in the basal ganglia facilitates psychotic symptoms across psychiatric conditions.",
keywords = "anhedonia, psychotic symptoms, PTSD, refugees, reward, salience",
author = "Uldall, {Sigurd Wiingaard} and Nielsen, {Mette {\O}degaard} and Jessica Carlsson and Birte Glenth{\o}j and Siebner, {Hartwig Roman} and Madsen, {Kristoffer Hougaard} and Madsen, {Camilla G{\o}bel} and Leffers, {Anne Mette} and Nejad, {Ayna Baladi} and Egill Rostrup",
year = "2020",
month = mar,
doi = "10.1080/20008198.2020.1730091",
language = "English",
volume = "11",
journal = "European Journal of Psychotraumatology",
issn = "2000-8198",
publisher = "Co-Action Publishing",
number = "1",

}

RIS

TY - JOUR

T1 - Associations of neural processing of reward with posttraumatic stress disorder and secondary psychotic symptoms in trauma-affected refugees

T2 - Asociaciones de procesamiento neuronal de recompensa con trastorno de estrés postraumático y síntomas psicóticos secundarios en refugiados afectados por trauma

AU - Uldall, Sigurd Wiingaard

AU - Nielsen, Mette Ødegaard

AU - Carlsson, Jessica

AU - Glenthøj, Birte

AU - Siebner, Hartwig Roman

AU - Madsen, Kristoffer Hougaard

AU - Madsen, Camilla Gøbel

AU - Leffers, Anne Mette

AU - Nejad, Ayna Baladi

AU - Rostrup, Egill

PY - 2020/3

Y1 - 2020/3

N2 - Background: Psychological traumatic experiences can lead to posttraumatic stress disorder (PTSD). Secondary psychotic symptoms are not common but may occur. Objectives: Since psychotic symptoms of schizophrenia have been related to aberrant reward processing in the striatum, using the same paradigm we investigate whether the same finding extends to psychotic and anhedonic symptoms in PTSD. Methods: A total of 70 male refugees: 18 PTSD patients with no secondary psychotic symptoms (PTSD-NSP), 21 PTSD patients with secondary psychotic symptoms (PTSD-SP), and 31 healthy controls (RHC) were interviewed and scanned with functional magnetic resonance imaging (fMRI) during a monetary incentive delay task. Using region of interest analysis of the prefrontal cortex and ventral striatum, we investigated reward-related activity. Results: Compared to RHC, participants with PTSD had decreased neural activity during monetary reward. Also, participants with PTSD-SP exhibited decreased activity in the associative striatum relative to participants with PTSD-NSP during processing of motivational reward anticipation which correlated with severity of psychotic symptoms. However, the difference between the two PTSD groups disappeared when PTSD severity and trauma exposure were accounted for. Conclusions: Anhedonia and secondary psychotic symptoms in PTSD are characterized by dysfunctional reward consumption and anticipation processing, respectively. The latter may reflect a mechanism by which abnormal reward signals in the basal ganglia facilitates psychotic symptoms across psychiatric conditions.

AB - Background: Psychological traumatic experiences can lead to posttraumatic stress disorder (PTSD). Secondary psychotic symptoms are not common but may occur. Objectives: Since psychotic symptoms of schizophrenia have been related to aberrant reward processing in the striatum, using the same paradigm we investigate whether the same finding extends to psychotic and anhedonic symptoms in PTSD. Methods: A total of 70 male refugees: 18 PTSD patients with no secondary psychotic symptoms (PTSD-NSP), 21 PTSD patients with secondary psychotic symptoms (PTSD-SP), and 31 healthy controls (RHC) were interviewed and scanned with functional magnetic resonance imaging (fMRI) during a monetary incentive delay task. Using region of interest analysis of the prefrontal cortex and ventral striatum, we investigated reward-related activity. Results: Compared to RHC, participants with PTSD had decreased neural activity during monetary reward. Also, participants with PTSD-SP exhibited decreased activity in the associative striatum relative to participants with PTSD-NSP during processing of motivational reward anticipation which correlated with severity of psychotic symptoms. However, the difference between the two PTSD groups disappeared when PTSD severity and trauma exposure were accounted for. Conclusions: Anhedonia and secondary psychotic symptoms in PTSD are characterized by dysfunctional reward consumption and anticipation processing, respectively. The latter may reflect a mechanism by which abnormal reward signals in the basal ganglia facilitates psychotic symptoms across psychiatric conditions.

KW - anhedonia

KW - psychotic symptoms

KW - PTSD

KW - refugees

KW - reward

KW - salience

U2 - 10.1080/20008198.2020.1730091

DO - 10.1080/20008198.2020.1730091

M3 - Journal article

C2 - 32194922

AN - SCOPUS:85081252467

VL - 11

JO - European Journal of Psychotraumatology

JF - European Journal of Psychotraumatology

SN - 2000-8198

IS - 1

M1 - 1730091

ER -

ID: 242359068