Impact of the circadian clock on fibrinolysis and coagulation in healthy individuals and cardiovascular patients – A systematic review

Research output: Contribution to journalReviewpeer-review

Documents

  • Fulltext

    Final published version, 611 KB, PDF document

Introduction: Human body functions exhibit a circadian rhythm generated in peripheral cells and synchronized by the suprachiasmatic nucleus (SCN), which mostly is entrained by the daily light/dark cycles. Activity, meals and posture are capable of interfering with the endogenous circadian rhythm of coagulation parameters. An increasing number of human disorders show a circadian component, and epidemiological studies find cardiovascular events to peak in the morning hours. The aim was to review the circadian rhythms impact on fibrinolysis and coagulation in healthy individuals and cardiovascular patients. Materials and methods: A total number of 25 studies were identified where 8 enrolled cardiovascular patients with or without healthy individuals. Using a MeSH-search in MEDLINE PubMed. Only original peer-reviewed papers were included. Results: Results showed substantial variance with respect to exhibition of circadian rhythms and/or peak/trough times. Circadian rhythms of fibrinolysis were less pronounced in cardiovascular patients than in healthy individuals with decreased levels in the morning hours compared to healthy inducing higher risk of blood clotting. Conclusions: Because of small studied group sizes and failure to control for entraining factors, larger studies are needed to fully establish the effects of the circadian rhythm on especially coagulation. The findings of chronobiologic rhythms in coagulation and fibrinolysis could suggest a need for a chrono-pharmacological approach when treating/preventing cardiovascular diseases.

Original languageEnglish
JournalThrombosis Research
Volume207
Pages (from-to)75-84
Number of pages10
ISSN0049-3848
DOIs
Publication statusPublished - Nov 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Ltd

    Research areas

  • Cardiovascular disease, Circadian rhythm, Fibrinolysis, Hypercoagulable states, Thrombosis

Number of downloads are based on statistics from Google Scholar and www.ku.dk


No data available

ID: 302555280