Impact of the circadian clock on fibrinolysis and coagulation in healthy individuals and cardiovascular patients – A systematic review
Research output: Contribution to journal › Review › peer-review
Documents
- Fulltext
Final published version, 611 KB, PDF document
Introduction: Human body functions exhibit a circadian rhythm generated in peripheral cells and synchronized by the suprachiasmatic nucleus (SCN), which mostly is entrained by the daily light/dark cycles. Activity, meals and posture are capable of interfering with the endogenous circadian rhythm of coagulation parameters. An increasing number of human disorders show a circadian component, and epidemiological studies find cardiovascular events to peak in the morning hours. The aim was to review the circadian rhythms impact on fibrinolysis and coagulation in healthy individuals and cardiovascular patients. Materials and methods: A total number of 25 studies were identified where 8 enrolled cardiovascular patients with or without healthy individuals. Using a MeSH-search in MEDLINE PubMed. Only original peer-reviewed papers were included. Results: Results showed substantial variance with respect to exhibition of circadian rhythms and/or peak/trough times. Circadian rhythms of fibrinolysis were less pronounced in cardiovascular patients than in healthy individuals with decreased levels in the morning hours compared to healthy inducing higher risk of blood clotting. Conclusions: Because of small studied group sizes and failure to control for entraining factors, larger studies are needed to fully establish the effects of the circadian rhythm on especially coagulation. The findings of chronobiologic rhythms in coagulation and fibrinolysis could suggest a need for a chrono-pharmacological approach when treating/preventing cardiovascular diseases.
Original language | English |
---|---|
Journal | Thrombosis Research |
Volume | 207 |
Pages (from-to) | 75-84 |
Number of pages | 10 |
ISSN | 0049-3848 |
DOIs | |
Publication status | Published - Nov 2021 |
Bibliographical note
Publisher Copyright:
© 2021 Elsevier Ltd
- Cardiovascular disease, Circadian rhythm, Fibrinolysis, Hypercoagulable states, Thrombosis
Research areas
Number of downloads are based on statistics from Google Scholar and www.ku.dk
ID: 302555280