Visual steady state in relation to age and cognitive function

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Visual steady state in relation to age and cognitive function. / Horwitz, Anna; Dyhr Thomsen, Mia; Wiegand, Iris; Horwitz, Henrik; Klemp, Marc; Nikolic, Miki; Rask, Lene; Lauritzen, Martin; Benedek, Krisztina.

In: PLOS ONE, Vol. 12, No. 2, e0171859, 2017.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Horwitz, A, Dyhr Thomsen, M, Wiegand, I, Horwitz, H, Klemp, M, Nikolic, M, Rask, L, Lauritzen, M & Benedek, K 2017, 'Visual steady state in relation to age and cognitive function', PLOS ONE, vol. 12, no. 2, e0171859. https://doi.org/10.1371/journal.pone.0171859

APA

Horwitz, A., Dyhr Thomsen, M., Wiegand, I., Horwitz, H., Klemp, M., Nikolic, M., ... Benedek, K. (2017). Visual steady state in relation to age and cognitive function. PLOS ONE, 12(2), [e0171859]. https://doi.org/10.1371/journal.pone.0171859

Vancouver

Horwitz A, Dyhr Thomsen M, Wiegand I, Horwitz H, Klemp M, Nikolic M et al. Visual steady state in relation to age and cognitive function. PLOS ONE. 2017;12(2). e0171859. https://doi.org/10.1371/journal.pone.0171859

Author

Horwitz, Anna ; Dyhr Thomsen, Mia ; Wiegand, Iris ; Horwitz, Henrik ; Klemp, Marc ; Nikolic, Miki ; Rask, Lene ; Lauritzen, Martin ; Benedek, Krisztina. / Visual steady state in relation to age and cognitive function. In: PLOS ONE. 2017 ; Vol. 12, No. 2.

Bibtex

@article{923eea08398a496fa59e3be500b43d90,
title = "Visual steady state in relation to age and cognitive function",
abstract = "Neocortical gamma activity is crucial for sensory perception and cognition. This study examines the value of using non-task stimulation-induced EEG oscillations to predict cognitive status in a birth cohort of healthy Danish males (Metropolit) with varying cognitive ability. In particular, we examine the steady-state VEP power response (SSVEP-PR) in the alpha (8Hz) and gamma (36Hz) bands in 54 males (avg. age: 62.0 years) and compare these with 10 young healthy participants (avg. age 27.6 years). Furthermore, we correlate the individual alpha-to-gamma difference in relative visual-area power (ΔRV) with cognitive scores for the older adults. We find that ΔRV decrease with age by just over one standard deviation when comparing young with old participants (p<0.01). Furthermore, intelligence is significantly negatively correlated with ΔRV in the older adult cohort, even when processing speed, global cognition, executive function, memory, and education (p<0.05). In our preferred specification, an increase in ΔRV of one standard deviation is associated with a reduction in intelligence of 48{\%} of a standard deviation (p<0.01). Finally, we conclude that the difference in cerebral rhythmic activity between the alpha and gamma bands is associated with age and cognitive status, and that ΔRV therefore provide a non-subjective clinical tool with which to examine cognitive status in old age.",
author = "Anna Horwitz and {Dyhr Thomsen}, Mia and Iris Wiegand and Henrik Horwitz and Marc Klemp and Miki Nikolic and Lene Rask and Martin Lauritzen and Krisztina Benedek",
year = "2017",
doi = "10.1371/journal.pone.0171859",
language = "English",
volume = "12",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "2",

}

RIS

TY - JOUR

T1 - Visual steady state in relation to age and cognitive function

AU - Horwitz, Anna

AU - Dyhr Thomsen, Mia

AU - Wiegand, Iris

AU - Horwitz, Henrik

AU - Klemp, Marc

AU - Nikolic, Miki

AU - Rask, Lene

AU - Lauritzen, Martin

AU - Benedek, Krisztina

PY - 2017

Y1 - 2017

N2 - Neocortical gamma activity is crucial for sensory perception and cognition. This study examines the value of using non-task stimulation-induced EEG oscillations to predict cognitive status in a birth cohort of healthy Danish males (Metropolit) with varying cognitive ability. In particular, we examine the steady-state VEP power response (SSVEP-PR) in the alpha (8Hz) and gamma (36Hz) bands in 54 males (avg. age: 62.0 years) and compare these with 10 young healthy participants (avg. age 27.6 years). Furthermore, we correlate the individual alpha-to-gamma difference in relative visual-area power (ΔRV) with cognitive scores for the older adults. We find that ΔRV decrease with age by just over one standard deviation when comparing young with old participants (p<0.01). Furthermore, intelligence is significantly negatively correlated with ΔRV in the older adult cohort, even when processing speed, global cognition, executive function, memory, and education (p<0.05). In our preferred specification, an increase in ΔRV of one standard deviation is associated with a reduction in intelligence of 48% of a standard deviation (p<0.01). Finally, we conclude that the difference in cerebral rhythmic activity between the alpha and gamma bands is associated with age and cognitive status, and that ΔRV therefore provide a non-subjective clinical tool with which to examine cognitive status in old age.

AB - Neocortical gamma activity is crucial for sensory perception and cognition. This study examines the value of using non-task stimulation-induced EEG oscillations to predict cognitive status in a birth cohort of healthy Danish males (Metropolit) with varying cognitive ability. In particular, we examine the steady-state VEP power response (SSVEP-PR) in the alpha (8Hz) and gamma (36Hz) bands in 54 males (avg. age: 62.0 years) and compare these with 10 young healthy participants (avg. age 27.6 years). Furthermore, we correlate the individual alpha-to-gamma difference in relative visual-area power (ΔRV) with cognitive scores for the older adults. We find that ΔRV decrease with age by just over one standard deviation when comparing young with old participants (p<0.01). Furthermore, intelligence is significantly negatively correlated with ΔRV in the older adult cohort, even when processing speed, global cognition, executive function, memory, and education (p<0.05). In our preferred specification, an increase in ΔRV of one standard deviation is associated with a reduction in intelligence of 48% of a standard deviation (p<0.01). Finally, we conclude that the difference in cerebral rhythmic activity between the alpha and gamma bands is associated with age and cognitive status, and that ΔRV therefore provide a non-subjective clinical tool with which to examine cognitive status in old age.

U2 - 10.1371/journal.pone.0171859

DO - 10.1371/journal.pone.0171859

M3 - Journal article

C2 - 28245274

VL - 12

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 2

M1 - e0171859

ER -

ID: 174125458