A new uPAR-targeting fluorescent probe for optical guided intracranial surgery in resection of a meningioma — a case report

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Standard

A new uPAR-targeting fluorescent probe for optical guided intracranial surgery in resection of a meningioma — a case report. / Skjøth-Rasmussen, Jane; Azam, Aleena; Larsen, Carl Christian; Scheie, David; Juhl, Karina; Kjaer, Andreas.

In: Acta Neurochirurgica, Vol. 164, No. 1, 2022, p. 267-271.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Skjøth-Rasmussen, J, Azam, A, Larsen, CC, Scheie, D, Juhl, K & Kjaer, A 2022, 'A new uPAR-targeting fluorescent probe for optical guided intracranial surgery in resection of a meningioma — a case report', Acta Neurochirurgica, vol. 164, no. 1, pp. 267-271. https://doi.org/10.1007/s00701-021-05051-3

APA

Skjøth-Rasmussen, J., Azam, A., Larsen, C. C., Scheie, D., Juhl, K., & Kjaer, A. (2022). A new uPAR-targeting fluorescent probe for optical guided intracranial surgery in resection of a meningioma — a case report. Acta Neurochirurgica, 164(1), 267-271. https://doi.org/10.1007/s00701-021-05051-3

Vancouver

Skjøth-Rasmussen J, Azam A, Larsen CC, Scheie D, Juhl K, Kjaer A. A new uPAR-targeting fluorescent probe for optical guided intracranial surgery in resection of a meningioma — a case report. Acta Neurochirurgica. 2022;164(1):267-271. https://doi.org/10.1007/s00701-021-05051-3

Author

Skjøth-Rasmussen, Jane ; Azam, Aleena ; Larsen, Carl Christian ; Scheie, David ; Juhl, Karina ; Kjaer, Andreas. / A new uPAR-targeting fluorescent probe for optical guided intracranial surgery in resection of a meningioma — a case report. In: Acta Neurochirurgica. 2022 ; Vol. 164, No. 1. pp. 267-271.

Bibtex

@article{ba0e8cd53366407da7ab02dff8f8b048,
title = "A new uPAR-targeting fluorescent probe for optical guided intracranial surgery in resection of a meningioma — a case report",
abstract = "Meningiomas are benign lesion although anot insignificant number experiences recurrences despite Simpson grade 1 removal. FG001 is a compound with a fluorophore (ICG) that binds to a urokinase-type plasminogen activator receptor (uPAR) and is currently investigated at our institution in a first-in-human trial. The patient presented with a plausible malignant glioma but proved to be a grade 1 meningioma. FG001 could delineated the tumor not only on the surface but supplementary in the cavity to remove safely the dural attachment. We present FG001 as a new promising tool for improved surgical radicality beyond the intended indication, provided that a prospective validation in a consecutive meningioma cohort demonstrates similar results.",
keywords = "Brain surgery, FG001, Fluorescense, Meningiomas, Radicality, uPar",
author = "Jane Skj{\o}th-Rasmussen and Aleena Azam and Larsen, {Carl Christian} and David Scheie and Karina Juhl and Andreas Kjaer",
note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.",
year = "2022",
doi = "10.1007/s00701-021-05051-3",
language = "English",
volume = "164",
pages = "267--271",
journal = "Acta Neurochirurgica, Supplement",
issn = "0065-1419",
publisher = "Springer Wien",
number = "1",

}

RIS

TY - JOUR

T1 - A new uPAR-targeting fluorescent probe for optical guided intracranial surgery in resection of a meningioma — a case report

AU - Skjøth-Rasmussen, Jane

AU - Azam, Aleena

AU - Larsen, Carl Christian

AU - Scheie, David

AU - Juhl, Karina

AU - Kjaer, Andreas

N1 - Publisher Copyright: © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.

PY - 2022

Y1 - 2022

N2 - Meningiomas are benign lesion although anot insignificant number experiences recurrences despite Simpson grade 1 removal. FG001 is a compound with a fluorophore (ICG) that binds to a urokinase-type plasminogen activator receptor (uPAR) and is currently investigated at our institution in a first-in-human trial. The patient presented with a plausible malignant glioma but proved to be a grade 1 meningioma. FG001 could delineated the tumor not only on the surface but supplementary in the cavity to remove safely the dural attachment. We present FG001 as a new promising tool for improved surgical radicality beyond the intended indication, provided that a prospective validation in a consecutive meningioma cohort demonstrates similar results.

AB - Meningiomas are benign lesion although anot insignificant number experiences recurrences despite Simpson grade 1 removal. FG001 is a compound with a fluorophore (ICG) that binds to a urokinase-type plasminogen activator receptor (uPAR) and is currently investigated at our institution in a first-in-human trial. The patient presented with a plausible malignant glioma but proved to be a grade 1 meningioma. FG001 could delineated the tumor not only on the surface but supplementary in the cavity to remove safely the dural attachment. We present FG001 as a new promising tool for improved surgical radicality beyond the intended indication, provided that a prospective validation in a consecutive meningioma cohort demonstrates similar results.

KW - Brain surgery

KW - FG001

KW - Fluorescense

KW - Meningiomas

KW - Radicality

KW - uPar

U2 - 10.1007/s00701-021-05051-3

DO - 10.1007/s00701-021-05051-3

M3 - Journal article

C2 - 34748074

AN - SCOPUS:85118852582

VL - 164

SP - 267

EP - 271

JO - Acta Neurochirurgica, Supplement

JF - Acta Neurochirurgica, Supplement

SN - 0065-1419

IS - 1

ER -

ID: 312696197